Protein Alignment Pde8 and PDE4A

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_001104777.1
• Gene: PDE4A / 5141
• HGNCID: 8780
• Length: 886
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 157/558 - (28%)
• Similarity: 252/558 - (45%)
• Gaps: 91/558 - (16%)

  Fly   496 EDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQM 560
            ||:.|:..:.:....::::....:||              .|||.....:|.         ||..
Human   174 EDLIVTPFAQVLASLRSVRSNFSLLT--------------NVPVPSNKRSPL---------GGPT 215

  Fly   561 DFI-ATLPQP--KEAPRGSLHSVRRC---------SFDVRSIASDGLRRTSLAKLTSLPLEAPIT 613
            ... |||.:.  ::..|.:|..:..|         ...|..:||...:|....:||.|      :
Human   216 PVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHL------S 274

  Fly   614 KIINLLSQVQENCSADEARLIDKVLE-------FLKREGLYSPQMKEIRTDDPIATDLIG-ALLT 670
            ::....:||.|..|   ...:||..|       ..:||...:|:.:..:...|....|.. :.:|
Human   275 EMSRSGNQVSEYIS---TTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQIT 336

  Fly   671 G-PSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPL 734
            | ..:..|...:|.:|.|.|          .|.....::.:.|:....|..:||.:.:......|
Human   337 GLKKLMHSNSLNNSNIPRFG----------VKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSL 391

  Fly   735 LYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKD 799
            ..:...:|:..|:.....|..:....::..:|.||.....||||.|||||:|:|...:.  |...
Human   392 TCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLA--TPAL 454

  Fly   800 MLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDK 864
            ..|...:|...||.|||.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |.:|.
Human   455 DAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKL-LQEDN 518

  Fly   865 INIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS------ 923
            .:||:||.|...:|.|..:|||:|||:|::|...||...::.          :|.:.||
Human   519 CDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV----------ETKKVTSSGVLLL 573

  Fly   924 ------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCS 982
                  |.:.|.::..||:|||.:|::...:|..||..|:|.|.|.|::|.:.| .||.|:.|.|
Human   574 DNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEI-SPMCDKHTAS 637

  Fly   983 IPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQIN 1018
            :.|||:|||:||:..:...|...:  |..:::..::.|
Human   638 VEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	6/42 (14%)
		PAS_9	463..539	CDD:290162	6/42 (14%)
		PDEase_I	775..1016	CDD:278654	101/254 (40%)
PDE4A	NP_001104777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..128
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..331		7/36 (19%)
		PDEase_I	432..673	CDD:278654	101/254 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..705
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..886

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850