Protein Alignment Pde8 and PDE3B

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_001350499.1
• Gene: PDE3B / 5140
• HGNCID: 8779
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 139/585 - (23%)
• Similarity: 231/585 - (39%)
• Gaps: 171/585 - (29%)

  Fly   563 IATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRR----TSLAKLTS--------------LPLE 609
            :.|:|:.:.:.....|.|             ||||    :||:.:.|              .|:|
Human   563 LLTIPKQRSSSVSLTHHV-------------GLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIE 614

  Fly   610 APITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSP-----------------------QM 651
            .|                 |.|..::|....|:|....:|                       .:
Human   615 FP-----------------DTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQML 662

  Fly   652 KEIRTDDPIATDLIGALLTGPS-----VYS-------------------SRR--SSNDSIIRTGS 690
            |.:.|.:...||    ..:|.|     ::|                   ||:  ...|..:...:
Human   663 KYVSTSESDGTD----CCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEA 723

  Fly   691 STRTAAIVPAKMKSNPIIME----LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATL 751
            .:.....:..::..:.|::|    |:::..:|:|.||:|.|.........|...|:..|.....|
Human   724 QSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLL 788

  Fly   752 NIDENVCKAWL---AVIEAHYRKSNTYHNSTHAADVMQA--------------------TG---- 789
            .|.:...:.::   ..:|..|| ...|||..||.||:.|                    ||
Human   789 EIFKIPTQQFMNYFRALENGYR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETD 852

  Fly   790 ----------AFIT--QLTNKDMLV------MDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDA 836
                      |:|:  ..:|.|...      :..:|.....:|||.||.|||||::|||..:|..
Human   853 SDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAP 917

  Fly   837 LAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAK 901
            .||||||.:||||||||..:.|.|...:.|...:||...:|..|..:|:.||||::.:||:.||:
Human   918 QAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAE 982

  Fly   902 FVSVFGGEEPRDHNPQ----TDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTD 962
            |     ..:..|.|..    ::|...:|:.::.||:||::.||:.....::|...|..|::.|.|
Human   983 F-----NAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGD 1042

  Fly   963 EEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDE 1027
            ||....||| .|..||::..:.|.|..||.:|:..:.:::::...:|          .||.:.:|
Human  1043 EEANLGLPI-SPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP----------GQWLEAEE 1096

  Fly  1028  1027
            Human  1097  1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	89/286 (31%)
PDE3B	NP_001350499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Interaction with RAPGEF3. /evidence=ECO:0000269|PubMed:21393242	1..25
		DUF1109	136..>282	CDD:310850
		PDEase_I	814..1088	CDD:306695	88/279 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850