DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and PDE3A

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_000912.3	Gene:	PDE3A / 5139	HGNCID:	8778	Length:	1141	Species:	Homo sapiens

Alignment Length:	722	Identity:	180/722 - (24%)
Similarity:	278/722 - (38%)	Gaps:	199/722 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 LITDDLL------RIQYANRATERLLNMRLD-EIISKQLEDIFVSDLSTISEQ--CKNIKEFDGI 519
            ||||.|.      .:..:.||...||:.:|. :.|.|..    |:.::::||.  |.:.:|..
Human   356 LITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPR----VNPVTSLSENYTCSDSEESS-- 414

  Fly   520 LTVRRKSQEGIPMHV-RVVPVACIGSAPTHLIFNFDVPGGQMDFIATL-PQP-----------KE 571
                .|.:..||..: |.:|...:....:.........|     :.|| |.|           :|
Human   415 ----EKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATG-----LPTLEPAPVRRDRSTSIKLQE 470

  Fly   572 APRGSLHS----VRRCSFDVRSIASD-------------GLRRTSLAKLTSL------PLE-API 612
            ||..|..|    |.......||..|.             ..|..:|||::.|      ||: .|.
Human   471 APSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPA 535

  Fly   613 TKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSV--- 674
            :.:::.:|.||...|||..          .::.|.|   ....|....|.||...:||.|.:
Human   536 SSLVSKISAVQFPESADTT----------AKQSLGS---HRALTYTQSAPDLSPQILTPPVICSS 587

  Fly   675 ----YSSRRSSNDSIIRTGSSTRT------AAIVPAKMKSN------------------------ 705
                ||....:::.:.|:|.:|||      .|.|.:..::|
Human   588 CGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRK 652

  Fly   706 -----------------------PIIMELLDESL----SWDFDIFKLEEITDYHPLLYLGMEMFR 743
                                   |::|:.||..:    :|:|.||.|.|.........|....:|
Human   653 ASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYR 717

  Fly   744 RFD---VFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ----------- 794
            .|:   :|....|.......:...:|..|| ...|||..||.||:.|.....||
Human   718 LFEDMGLFEAFKIPIREFMNYFHALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVIND 781

  Fly   795 --------------------LTNKDMLVMD-----------RMEEATALIAAAAHDVDHPGRSSA 828
                                :.:|...|.|           .:|.....:|||.||.|||||::|
Human   782 HGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNA 846

  Fly   829 FLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMT 893
            ||..::...||||||.:||||||||..:.|.:...:.|...|||...:|..|..:|:.||||::.
Human   847 FLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLK 911

  Fly   894 RHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYF 958
            :||:.:|||......:...|   .|:|...:|:.:|.||:||::.||:..:..::|...|..|::
Human   912 KHFDFVAKFNGKVNDDVGID---WTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973

  Fly   959 MQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQW- 1022
            .|.|||....||| .|..||:...:...|..||.:|:..:.::::|...||          .:|
Human   974 EQGDEEASLGLPI-SPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMP----------GKWV 1027

  Fly  1023 KKYDEQG 1029
            :..||.|
Human  1028 EDSDESG 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	21/84 (25%)
		PAS_9	463..539	CDD:290162	21/84 (25%)
		PDEase_I	775..1016	CDD:278654	89/282 (32%)
PDE3A	NP_000912.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..482		10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..640		10/49 (20%)
		PDEase_I	751..1012	CDD:306695	86/264 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1023..1062		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1141
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154165
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850