DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and PDE1C

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_016867753.1	Gene:	PDE1C / 5137	HGNCID:	8776	Length:	804	Species:	Homo sapiens

Alignment Length:	471	Identity:	124/471 - (26%)
Similarity:	213/471 - (45%)	Gaps:	84/471 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 KEAPRGSL-HSVR--------------------RCSFDVRSIASDGLRRTSLAKLTSLPLEAPIT 613
            ||.||.:: |..|                    :.||.:||:...              ||....
Human   101 KEKPRPTIVHDPRPPEEILADELPQLDSPEVLVKTSFRLRSLVKQ--------------LERGEA 151

  Fly   614 KIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTD--DPIATDLIGALLTGPSVYS 676
            .:::|...::...:..|:..||:....|..|    .::.:|::|  .....|.:.:..|......
Human   152 SVVDLKKNLEYAATVLESVYIDETRRLLDTE----DELSDIQSDAVPSEVRDWLASTFTRQMGMM 212

  Fly   677 SRRSSNDSIIRTGSSTRTAAIVPAKM---KSN-------PIIMELLDESLSWDFDIFKLEEITDY 731
            .|||......::......|.|...:|   .||       |.::|.|.:...|.||:|.|.|.:..
Human   213 LRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGD 277

  Fly   732 HPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAADVMQA-------T 788
            |.|.::..|:..|:|:.:...|..:...:::..:|..|.| .|.|||..|||||.|.       |
Human   278 HALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKT 342

  Fly   789 GA--FITQLTNKDMLVMDRMEEATALI-AAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENH 850
            |.  ::|:|            |..|:| :||.||.:|.|.::.|...:....|:||||.:|||||
Human   343 GVANWLTEL------------EIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH 395

  Fly   851 HAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHN 915
            |.:..::|...|:::||..||.|:.::..|:.:|:|::||:|:.||:.:....:..       ..
Human   396 HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTAL-------QQ 453

  Fly   916 PQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRAT 980
            |:..|:...|  .:::..||:|:||:.......|...:.||:|.|.|.|.:..||. .|:.||.:
Human   454 PEAIEKPKAL--SLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPF-SPLCDRKS 515

  Fly   981 CSIPKSQIGFIEYIIQ 996
            ..:.:||:|||::|::
Human   516 TMVAQSQVGFIDFIVE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	75/232 (32%)
PDE1C	XP_016867753.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154171
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850