DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde8 and PDE1A

DIOPT Version :10

Sequence 1:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster
Sequence 2:XP_016859783.1 Gene:PDE1A / 5136 HGNCID:8774 Length:586 Species:Homo sapiens


Alignment Length:410 Identity:113/410 - (27%)
Similarity:195/410 - (47%) Gaps:46/410 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   608 LEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDD--PIATDLIGALLT 670
            ||.....:::|...::...|..||..||:....|..|    .::.:|:||.  ....|.:.:..|
Human    42 LERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTE----DELSDIQTDSVPSEVRDWLASTFT 102

  Fly   671 GPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSN-----------PIIMELLDESLSWDFDIFK 724
            .....:.::.......|:......|.|...:|...           .:|:.|.|.. .|.||:|.
Human   103 RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVD-KWSFDVFA 166

  Fly   725 LEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAADVMQA- 787
            |.|.:..|.|.::..|:|.|:|:.....|..:....:...:|..|.| .|.|||..|||||.|. 
Human   167 LNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTV 231

  Fly   788 ------TGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTV 846
                  || .:..||..::|.|        :.|||.||.:|.|.::.|...:...:|:||||.:|
Human   232 HYIMLHTG-IMHWLTELEILAM--------VFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSV 287

  Fly   847 LENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEP 911
            |||||.:..::| :.::::||..||.|:.::..|:.:|:|:|:|:|:.||:.:...         
Human   288 LENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNI--------- 342

  Fly   912 RDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMF 976
            |:...|.:.........:::..||:|:||:..:....|...:.||:|:|.|:|.:..||. .|:.
Human   343 RNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPF-SPLC 406

  Fly   977 DRATCSIPKSQIGFIEYIIQ 996
            ||.:..:.:||||||::|::
Human   407 DRKSTMVAQSQIGFIDFIVE 426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde8NP_001163275.2 NtrB 446..>539 CDD:443061
PDEase_I 775..1016 CDD:459723 74/229 (32%)
PDE1AXP_016859783.1 PDEase_I_N 73..133 CDD:462497 10/63 (16%)
PDEase_I 218..439 CDD:459723 74/229 (32%)
Blue background indicates that the domain is not in the aligned region.

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