DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and PDE1A

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_016859783.1	Gene:	PDE1A / 5136	HGNCID:	8774	Length:	586	Species:	Homo sapiens

Alignment Length:	410	Identity:	113/410 - (27%)
Similarity:	195/410 - (47%)	Gaps:	46/410 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   608 LEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDD--PIATDLIGALLT 670
            ||.....:::|...::...|..||..||:....|..|    .::.:|:||.  ....|.:.:..|
Human    42 LERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTE----DELSDIQTDSVPSEVRDWLASTFT 102

  Fly   671 GPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSN-----------PIIMELLDESLSWDFDIFK 724
            .....:.::.......|:......|.|...:|...           .:|:.|.|.. .|.||:|.
Human   103 RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVD-KWSFDVFA 166

  Fly   725 LEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAADVMQA- 787
            |.|.:..|.|.::..|:|.|:|:.....|..:....:...:|..|.| .|.|||..|||||.|.
Human   167 LNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTV 231

  Fly   788 ------TGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTV 846
                  || .:..||..::|.|        :.|||.||.:|.|.::.|...:...:|:||||.:|
Human   232 HYIMLHTG-IMHWLTELEILAM--------VFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSV 287

  Fly   847 LENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEP 911
            |||||.:..::| :.::::||..||.|:.::..|:.:|:|:|:|:|:.||:.:...
Human   288 LENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNI--------- 342

  Fly   912 RDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMF 976
            |:...|.:.........:::..||:|:||:..:....|...:.||:|:|.|:|.:..||. .|:.
Human   343 RNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPF-SPLC 406

  Fly   977 DRATCSIPKSQIGFIEYIIQ 996
            ||.:..:.:||||||::|::
Human   407 DRKSTMVAQSQIGFIDFIVE 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	74/229 (32%)
PDE1A	XP_016859783.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920