Protein Alignment Pde8 and PDE11A

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_058649.3
• Gene: PDE11A / 50940
• HGNCID: 8773
• Length: 933
• Species: Homo sapiens
• Alignment Length: 975
• Identity: 209/975 - (21%)
• Similarity: 346/975 - (35%)
• Gaps: 260/975 - (26%)

  Fly   178 PLSVSFGGGG------GRSALQPEIVEAI-RSLDVPALRLNNLSFDGSTDPKGERNHAEEEPLTP 235
            |||.|:.||.      .|.|.|.|:.::. ||   .|:.:|. ::|.....:.      :|||
Human    97 PLSPSWAGGSRGDGNLQRRASQKELRKSFARS---KAIHVNR-TYDEQVTSRA------QEPL-- 149

  Fly   236 GHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYP 300
                  |.|.||   .|.|||.||                    |||..........:.::
Human   150 ------SSVRRR---ALLRKASSL--------------------PPTTAHILSALLESRVN---- 181

  Fly   301 TVLPPNPPLKALLVFHKSDSICEAITAAC--QRH---QLDVTLVKSKEEALDTLQKSY------- 353
              ||..||              .||...|  ::|   |..:.|||.....||....||
Human   182 --LPRYPP--------------TAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVC 230

  Fly   354 --ATAQCYHLIIIDARS-------SKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIA 409
              ..|....|.:::..:       ||..|.             |..|.:..|..:  |..:.:..
Human   231 LMVDADRCSLFLVEGAAAGKKTLVSKFFDV-------------HAGTPLLPCSST--ENSNEVQV 280

  Fly   410 LLDAGVNRCV---AETTNL--------------AMCSVELKQILHSIIRPHN--VMSTQQALYTA 455
            ....|:...|   .||.|:              .:...:.|.:|...||..:  ::...|    |
Human   281 PWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQ----A 341

  Fly   456 LHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGIL 520
            ::::.|....|:|          .|:::.|.|      ....|.:|:....:...|..:....:|
Human   342 INKIPEGAPFTED----------DEKVMQMYL------PFCGIAISNAQLFAASRKEYERSRALL 390

  Fly   521 TV------RRKSQEGIP---MHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPK---EAP 573
            .|      .:...|.|.   ||.....:.| ......|:.:.:.|..:......|..||   :|.
Human   391 EVVNDLFEEQTDLEKIVKKIMHRAQTLLKC-ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAE 454

  Fly   574 RGSLHSVRRCSFDVRSIASDGLRRTSLAKL---TSLPL-------------EAP----------- 611
            .....|:.:.|:      ||.|...|:|:|   |.||:             ||.
Human   455 NSFKESMEKSSY------SDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVL 513

  Fly   612 -------------ITKIINLLSQVQENCSADEA--RLIDKVLEF----LKREGLYSPQMKEIRTD 657
                         :.:::|.|    :....|:|  ||.:..:.|    :....:|. |:|:....
Human   514 CVPIWNSNHQIIGVAQVLNRL----DGKPFDDADQRLFEAFVIFCGLGINNTIMYD-QVKKSWAK 573

  Fly   658 DPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDI 722
            ..:|.|::.        |.:..|.             |.:...|..:.|::.||..:.:  .||.
Human   574 QSVALDVLS--------YHATCSK-------------AEVDKFKAANIPLVSELAIDDI--HFDD 615

  Fly   723 FKLEEITDYHPLLYLGMEMFRRFDVFATLNID-ENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQ 786
            |.|    |...::...:.||....:.....|| |.:|: ||..:..:||.. .|||..||.:|.|
Human   616 FSL----DVDAMITAALRMFMELGMVQKFKIDYETLCR-WLLTVRKNYRMV-LYHNWRHAFNVCQ 674

  Fly   787 ATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHH 851
            ...|.:|....:|:|.  .:|....::....||:||.|.::||...|..|||.||.....||:||
Human   675 LMFAMLTTAGFQDILT--EVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHH 737

  Fly   852 AAITFK---LTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRD 913
                |.   :.|..:..|||.||..:.|......:...||||::|.:||...:|..:....| .|
Human   738 ----FNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGE-YD 797

  Fly   914 HNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDR 978
            .|.:...:   :.|.||:...|:....:|.:...:.|..:..|:|.|.|.|:.........:|||
Human   798 WNIKNHRD---IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDR 859

  Fly   979 -ATCSIPKSQIGFIEYIIQDMMHAWESF-IDMPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQP 1041
             ....:|:.|:.:|:.|...:..|.... :.:..::..:..|.|:|::..::  ..||...:..|
Human   860 NRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK--RLLASTASSSP 922

  Fly  1042  1041
            Human   923  922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	15/88 (17%)
		PAS_9	463..539	CDD:290162	14/84 (17%)
		PDEase_I	775..1016	CDD:278654	67/245 (27%)
PDE11A	NP_058649.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..125		10/27 (37%)
		GAF	217..380	CDD:214500	31/197 (16%)
		GAF	402..568	CDD:214500	33/177 (19%)
		PDEase_I	663..898	CDD:278654	67/244 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850