DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde3a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_059033.1	Gene:	Pde3a / 50678	RGDID:	61942	Length:	1141	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	152/612 - (24%)
Similarity:	232/612 - (37%)	Gaps:	171/612 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   556 PGGQMDFIATLPQPKEA-PRGS-----LHSVRRCSF----DVRSIASDGLRR--TSLAKLTSLPL 608
            ||| :|.|:.:|.|..: |:||     :..:....|    :|.:....|..|  |.......|..
  Rat   513 PGG-LDKISPVPSPSSSPPQGSPTSSPVSGIASVQFPESPEVTTKRGPGSHRALTYTQSAPDLSP 576

  Fly   609 EAPITKIINLLSQVQENCSA-----DEARLIDKVLEFLKREGLYSPQM-KEIRTDD--PIATDLI 665
            :.|.:.:|         ||:     .:....|...|   |.|   |.| |..||||  .:.:|
  Rat   577 QIPPSPVI---------CSSCGRPYSQGNPADGPSE---RSG---PAMQKPNRTDDTSQVTSD-- 624

  Fly   666 GALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKS--------------------NPIIME 710
                     |.:..:|:.|.|............|.:..|                    .|::|:
  Rat   625 ---------YETNNNSDSSDILQNDEEAECQREPLRKASACGTYTPQTMIFLDKPILAPEPLVMD 680

  Fly   711 ----LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFD---VFATLNIDENVCKAWLAVIEAH 768
                ::|:..:|:|.||.|.|.........|....:|.|:   :|....|.......:...:|..
  Rat   681 NLDSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIG 745

  Fly   769 YRKSNTYHNSTHAADVMQATGAFITQ-------------------------------LTNKDMLV 802
            || ...|||..||.||:.|.....||                               :.:|...|
  Rat   746 YR-DIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKAYHV 809

  Fly   803 MD-----------RMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITF 856
            .|           .:|.....:|||.||.|||||::|||..::...||||||.:||||||||..:
  Rat   810 PDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAW 874

  Fly   857 KLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEE 921
            .|.:...:.|...|||...:|..|..:|:.||||::.:||:.:|||.:....:...|   .|:|.
  Rat   875 NLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGID---WTNEN 936

  Fly   922 TSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKS 986
            ..:|:.:|.||:||::.||:.....:.|...||.|::.|.|||....||| .|..||:...:...
  Rat   937 DRLLVCQMCIKLADINGPAKCKDLHLRWTEGIASEFYEQGDEEASLGLPI-SPFMDRSAPQLANL 1000

  Fly   987 QIGFIEYIIQDMMHAWESFIDMP------------------------------------------ 1009
            |..||.:|:..:.|:::|...||
  Rat  1001 QESFISHIVGPLCHSYDSAGLMPGKWVDDSDDSGDTDDPEEEEEEAETPHEEETCENSEAPRKKS 1065

  Fly  1010 --------QLITYMQINYSQWKKYDEQ 1028
                    |:..::..|:..|||..|:
  Rat  1066 FKRRRIYCQITQHLLQNHMMWKKVIEE 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	92/332 (28%)
Pde3a	NP_059033.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..309
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..643		36/156 (23%)
		PDEase_I	751..1012	CDD:278654	87/264 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1062		0/37 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1098..1141
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347776
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850