Protein Alignment Pde8 and Pde6

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Alignment Length: 1041
• Identity: 215/1041 - (20%)
• Similarity: 381/1041 - (36%)
• Gaps: 259/1041 - (24%)

  Fly    95 PANGGIRPKSEGACPEMKVETISAATSPPPPRPLHGTSGPVAIS----------LPFVGRN---- 145
            ||.|...|............|.||::|    :||...:...|||          :|..|..
  Fly     7 PAGGAASPVEMSTTSSSSAATTSASSS----KPLTNGANKTAISTAAGGVTPGAVPGPGSGAIPA 67

  Fly   146 SSKTPEEMELEYEANVEAESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALRL 210
            ||.:..:::||:.......:|..:|.....|:.::.:  |.....:..|...:|  |:.....:.
  Fly    68 SSSSGNQVKLEHHHRQSNNNRPAVTNRSSETKLMTPT--GSSSSPSQSPSQTQA--SIQTQTSQQ 128

  Fly   211 NNLSFDGSTDPKGERNHA----EEEPLTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLH 271
            :.|:...:|..:.:.:..    ||:|    ...|..:..|.....|.| .....|.|.|.
  Fly   129 DRLAKASTTASQQDVDEVARLFEEKP----EAFEKWLTERAPPEALSR-LQEFIENRKPH----- 183

  Fly   272 LLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLD- 335
                  |.|....:.|:.:.     ...|||...:|  ::|     |:|...:: ..|:||.:|
  Fly   184 ------KRPSVTSDLFQQWM-----AASPTVQQKSP--RSL-----SNSSASSL-PECRRHLMDL 229

  Fly   336 ------VTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLD--AEHIARTIRHTHGHHLTTI 392
                  :.|::.....||      ....| |.|:::.....:.|  :..:|:. ..|:.:.:..:
  Fly   230 DEGELFMELIRDVANELD------IDVLC-HKILVNVGLLTHADRGSLFLAKG-TPTNKYLVAKL 286

  Fly   393 IAVCKKSFFEKDDV-------LIALLDAGVNRCVAETTNLA-----------MCSVELKQ----- 434
            ..|.:|:.. ||.|       :|.....|:...||:|..:.           .|.::||.
  Fly   287 FDVTQKTAL-KDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTN 350

  Fly   435 ----------------ILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLL 483
                            :...|.:.:..|...:.......|     .:|...:.||.|     :|.
  Fly   351 AILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRR-----YLTFCGIGIQNA-----QLF 405

  Fly   484 NMRLDEIISKQLEDIFVSDLSTISEQCKNIK-EFDGILTVRRKSQEGIPMHVRVVPVACIGSAPT 547
            .|.:.|....|   |.::...:|.|:..|:: ....|:|..|:..:.....|.:|.:.|..::..
  Fly   406 EMSVQEYRRNQ---ILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHL 467

  Fly   548 HLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSI--------------ASDGLRRT 598
            ..|               :.:|.:....::.|..  ||:.:.:              .:..:.|.
  Fly   468 EKI---------------IEKPNQPATRAIKSAD--SFEEKKMRNRFTVLFELGGEYQAANVSRP 515

  Fly   599 SLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATD 663
            |:::|:|..| |.|.:.:....|....|.         |:|:::       ...:||.:|.|  |
  Fly   516 SVSELSSSTL-AQIAQFVATTGQTVNICD---------VIEWVR-------DHNQIRAEDEI--D 561

  Fly   664 LIGALLTGPSVYSSRR-----------------SSNDSI-----------IRTGSSTRTAAIVPA 700
            ...|:|..|.:.:.::                 .|:.||           |........|..:.|
  Fly   562 STQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMA 626

  Fly   701 KMK--------------------SNPIIMELLDESL-SWDFDIFKLEEITDYHPLLYLGMEMFRR 744
            |.|                    :..:|.|....:| |:.|..|:|.:......:|    .||.:
  Fly   627 KQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVL----RMFMQ 687

  Fly   745 FDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEA 809
            .::.:...|..:|...|:..:..:||... |||..||.:|.|...|.:.  |.|....|..:|..
  Fly   688 CNLVSQFQIPYDVLCRWVLSVRKNYRPVK-YHNWRHALNVAQTMFAMLK--TGKMERFMTDLEIL 749

  Fly   810 TALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFK---LTLGDDKINIFKNL 871
            ..|:|...||:||.|.::||...:...||:||...| :|:||    |.   :.|..:..|||:.|
  Fly   750 GLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTST-MEHHH----FDQCVMILNSEGNNIFQAL 809

  Fly   872 DKETYKSARSTIIDMILATEMTRHFEHLAKFVSV-------FGGEEPRDHNPQTDEETSILMRRM 929
            ..|.|:|...|:...||:|::..:|:....|:.:       :.|||.:|           |:..|
  Fly   810 SPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKD-----------LLCGM 863

  Fly   930 LIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDR-ATCSIPKSQIGFIEY 993
            ::...|||..|:|.:...:.|:.:|:|:|.|.|.||.:.....:.|.|| ....:||.|:|||:.
  Fly   864 MMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDV 928

  Fly   994 I 994
            |
  Fly   929 I 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	17/80 (21%)
		PAS_9	463..539	CDD:290162	17/76 (22%)
		PDEase_I	775..1016	CDD:278654	73/231 (32%)
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	28/177 (16%)
		GAF	431..619	CDD:214500	35/223 (16%)
		PDEase_I	717..950	CDD:278654	73/231 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020