Protein Alignment Pde8 and Pde11

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 1150
• Identity: 227/1150 - (19%)
• Similarity: 383/1150 - (33%)
• Gaps: 333/1150 - (28%)

  Fly    16 SSAKSSSSSAGRENPSSEPDSD-----TEPYAI---------AIAAISDRSGDNRNERPRPLPDD 66
            ||:..||||.|....|:.|...     .:||..         |.:....|..|..:.|.....|:
  Fly   141 SSSNGSSSSGGGVQTSATPQQQQQYQVQQPYQYQYQHHYHHQANSPQHHRPYDPEHARMEAWLDE 205

  Fly    67 D---------------SIRSRLISAAHLDLDVGLELASDSTAVPANGGIRPKSEGACPEMKVETI 116
            :               ::.:.|:|.|   ...|.::.|.::...|||.......|:.....|..|
  Fly   206 NQEFVQDYFIRKATRQTVDAWLVSHA---TSAGNDVVSSTSPTHANGQTSSSRGGSGATTPVRKI 267

  Fly   117 SA-----------------------ATSPPPPRPLHGTSGPVAISLPFVG--------------- 143
            ||                       :..||..   :|:.|....:|..||
  Fly   268 SAHEFERGGLLKPIVNTIDGTPTFLSIGPPMD---NGSVGGSCSNLQNVGGVVAGQYQYNHQQHH 329

  Fly   144 RNSSKTPEEMELEYEANVEAESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPAL 208
            .|.:.........|:|.....|.               |.|..||.|.          :...|:|
  Fly   330 HNHAHLHHSQHSHYQAGGAVGSS---------------SLGSTGGASG----------AGGAPSL 369

  Fly   209 RLNNLSFDGSTDPKGERNHAEEEPLTPGH------DHEDSVVLRRKVNCLERKAHSLYERRLPRV 267
            ..:..:.:|...|   ..|..:.|.....      |.::.:....|..|.|.:..:|..:.|..|
  Fly   370 GGSGGAGNGHQYP---YYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNV 431

  Fly   268 PKL-------HLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAI 325
            ..|       ..||.|:.|.|                         ..||..||....|
  Fly   432 SILLNADRGSLFLVQGRCNGP-------------------------DGLKKCLVSKLFD------ 465

  Fly   326 TAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLI-------IIDARSSKNLDAEHIART--- 380
              .|.|..::      :.|..|.::.::.|....|:.       |.||...:..:.|..:.|
  Fly   466 --VCPRSTVE------EMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYR 522

  Fly   381 --------IRHTHGHHLTTIIAVCK-------KSFFEKDDVLIA--LLDAGVNRCVAETTNLAMC 428
                    |:.:.|    .:|.|.:       :.|.|.|:.:.:  |...|:....|:....:..
  Fly   523 TKALLCMPIKDSSG----DVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQL 583

  Fly   429 SVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISK 493
            .::..|:|..:.|   ::..:|:  |..|.:..::.....|::.|    ..:.||....|:....
  Fly   584 EIKRNQVLLDLAR---MIFEEQS--TIEHMVFRILTHMQSLIQCQ----RVQILLVHEADKGSFS 639

  Fly   494 QLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEG-IPMHVRVV-PVACIGSAPTHLIFNFDVP 556
            ::.|...:|||  .|:.          |.|....|. .|:::.:. .||..|.       ..:||
  Fly   640 RVFDFEANDLS--EEEA----------TSRTSPYESRFPINIGITGHVATTGE-------TVNVP 685

  Fly   557 GGQMD--FIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLL 619
            ....|  |.|::.:            ..| |..|||....: :.||.:         |..:|.|:
  Fly   686 NAYEDDRFDASVDE------------NSC-FKHRSILCMAI-KNSLGQ---------IIGVIQLI 727

  Fly   620 SQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDS 684
            ::..|             |:|.|.:..:....               |:..|..::::.....
  Fly   728 NKFNE-------------LDFTKNDENFVEAF---------------AIFCGMGIHNTHMYEK-- 762

  Fly   685 IIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFD--------------IFKLEE--ITDYH- 732
                       |||  .|....:.:|:|....|...|              .|:|.:  ..|.|
  Fly   763 -----------AIV--AMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHF 814

  Fly   733 ---PLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ 794
               ..|...:.||...|.....:||..|...||..::.:|| :.||||..||.:|.|...|.:|
  Fly   815 EDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILT- 877

  Fly   795 LTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFK-- 857
             |.:...:...:|....:|....||:||.|.:::|...::..||.||:..| :|:||    |.
  Fly   878 -TTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTST-MEHHH----FDQC 936

  Fly   858 -LTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFV-------SVFGGEEPRDH 914
             :.|......|..||..:.|......:.|.||:|::..:|:....|:       |.:..||||
  Fly   937 LMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPR-- 999

  Fly   915 NPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQR-HLPIVMPMFDR 978
                     .|:|.|.:.|.|:|...:|.:.....|..::.|:|.|.|.|||. ::..:..|...
  Fly  1000 ---------ALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNRE 1055

  Fly   979 ATCSIPKSQIGFIEYIIQDMMHAWESFID-MPQLITYMQINYSQW 1022
            ....:|..|:.||:.|...:..|:.:..| :..|:..::.|...|
  Fly  1056 KEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHW 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	14/81 (17%)
		PAS_9	463..539	CDD:290162	14/77 (18%)
		PDEase_I	775..1016	CDD:278654	67/252 (27%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	35/204 (17%)
		GAF	611..762	CDD:214500	38/224 (17%)
		PDEase_I	859..1094	CDD:278654	67/252 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459131
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950