Protein Alignment Pde8 and Pde1c

DIOPT Version :10

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Alignment Length: 1061
• Identity: 221/1061 - (20%)
• Similarity: 349/1061 - (32%)
• Gaps: 383/1061 - (36%)

  Fly     6 PKFSKVFRRKSSAKSSSSSAGRENPSSEPDSDTEPYAIAIAAISDRSGDNRNERPRPLPDDDSIR 70
            |...::..|.|...:.|:|||....|::..|::.|.|.|...:...|.:..|.    |.|:..|.
  Fly   298 PLAERLSFRASGGSNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNATNY----LADNIQIS 358

  Fly    71 SRLIS--------------AAH-LDLDVGLELASDSTAVPANGGIRPKSEGACPEMKVETISAAT 120
            |..:|              |.| :::.||.......|.:|...|           ...||.|..:
  Fly   359 SANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESG-----------HSFETPSNMS 412

  Fly   121 ---------SPPP---PRPLHGTSGPVAISLPFVGRNSSKTPEEMELEYEANVEAESRDIMTPLR 173
                     |.||   |..|:..:|.:        |:..:..:...:.||        |:...|.
  Fly   413 FTAGQWDTESLPPVDTPDALNKAAGRI--------RSLLRRMDHETVAYE--------DMQRNLH 461

  Fly   174 RNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALRLN-NLSFDGSTDPKGERNHA-------EE 230
            ...|.|...|            |.|:....:.....|| :....|..|.:.:.|::       |.
  Fly   462 YAARVLEAVF------------IDESREGCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEA 514

  Fly   231 EP------LTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRT 289
            .|      :|||.|::||:..|.|              .:.:.|:.|   :|...||:....
  Fly   515 SPGGAGAGVTPGADNQDSIESRTK--------------GVSQAPQTH---SGPTGPPSNTSS--- 559

  Fly   290 FQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYA 354
                      .|:..|.|.|:..|     :::.|:              |..:..:.|...|...
  Fly   560 ----------ETIAQPAPKLQPAL-----ETVRES--------------VMEESPSKDPGDKGPP 595

  Fly   355 TAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCV 419
            .......:.....:|.:..||..|:......|                         .||
  Fly   596 PPASTSTLTSQTTTSSSATAEPSAKAAESQAG-------------------------SAG----- 630

  Fly   420 AETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLN 484
                :...||           .|           .|:||.:.  |.|....|....|:.  ||.:
  Fly   631 ----SSGSCS-----------NP-----------AAVHRQRR--LRTPTWARSMSTNKT--RLAD 665

  Fly   485 MRLDEIISKQLEDIFVSDL-----STISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGS 544
            .  |:.:|:...|....::     ||.:.|         :.|.||||.|
  Fly   666 E--DDELSEVQPDAVPPEVREWLASTFTRQ---------MATSRRKSDE---------------- 703

  Fly   545 APTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLE 609
                                   :||.  |...|::|...|..|.     .||.|.:.||:.|
  Fly   704 -----------------------KPKF--RSVAHAIRAGIFVDRM-----YRRVSSSALTAFP-- 736

  Fly   610 APITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSV 674
                                                                             
  Fly   737 ----------------------------------------------------------------- 736

  Fly   675 YSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGM 739
                                           |.::.||.....|.||:|.|.|......:.|:..
  Fly   737 -------------------------------PDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAY 770

  Fly   740 EMFRRFDVFATLNIDENVCKAWLAVIEAHY-RKSNTYHNSTHAADVMQA-------TGAFITQLT 796
            |:|.|:.......|...:.:|:|..:|..| |..|.|||:.||.||||.       || .:..||
  Fly   771 ELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTG-LMNWLT 834

  Fly   797 NKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLG 861
            :        :|...:|:||..||.:|.|.::.|...|....|:||||..|||||||:.:|:| |.
  Fly   835 D--------LEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRL-LR 890

  Fly   862 DDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILM 926
            :|:.||..:|.:|.::..|..:|:|:|.|:||.||:.:.....:...:|      .|.::..:|
  Fly   891 EDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQE------ATIDKQKVL- 948

  Fly   927 RRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFI 991
             .:::...|:|:||:.......|...:.||:|.|.|.||:..||. .|:.||....:.:|||.||
  Fly   949 -SLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPF-SPLCDRNNTLVAESQICFI 1011

  Fly   992 EYIIQDMMHAWESFIDMPQLI 1012
            ::|::..|....   ||.:||
  Fly  1012 DFIVEPSMGVMS---DMLELI 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	NtrB	446..>539	CDD:443061	21/97 (22%)
		PDEase_I	775..1016	CDD:459723	83/245 (34%)
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	20/111 (18%)
		PDEase_I	807..1027	CDD:459723	81/241 (34%)