DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde1c

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster

Alignment Length:	1061	Identity:	221/1061 - (20%)
Similarity:	349/1061 - (32%)	Gaps:	383/1061 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PKFSKVFRRKSSAKSSSSSAGRENPSSEPDSDTEPYAIAIAAISDRSGDNRNERPRPLPDDDSIR 70
            |...::..|.|...:.|:|||....|::..|::.|.|.|...:...|.:..|.    |.|:..|.
  Fly   298 PLAERLSFRASGGSNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNATNY----LADNIQIS 358

  Fly    71 SRLIS--------------AAH-LDLDVGLELASDSTAVPANGGIRPKSEGACPEMKVETISAAT 120
            |..:|              |.| :::.||.......|.:|...|           ...||.|..:
  Fly   359 SANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESG-----------HSFETPSNMS 412

  Fly   121 ---------SPPP---PRPLHGTSGPVAISLPFVGRNSSKTPEEMELEYEANVEAESRDIMTPLR 173
                     |.||   |..|:..:|.:        |:..:..:...:.||        |:...|.
  Fly   413 FTAGQWDTESLPPVDTPDALNKAAGRI--------RSLLRRMDHETVAYE--------DMQRNLH 461

  Fly   174 RNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALRLN-NLSFDGSTDPKGERNHA-------EE 230
            ...|.|...|            |.|:....:.....|| :....|..|.:.:.|::       |.
  Fly   462 YAARVLEAVF------------IDESREGCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEA 514

  Fly   231 EP------LTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRT 289
            .|      :|||.|::||:..|.|              .:.:.|:.|   :|...||:....
  Fly   515 SPGGAGAGVTPGADNQDSIESRTK--------------GVSQAPQTH---SGPTGPPSNTSS--- 559

  Fly   290 FQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYA 354
                      .|:..|.|.|:..|     :::.|:              |..:..:.|...|...
  Fly   560 ----------ETIAQPAPKLQPAL-----ETVRES--------------VMEESPSKDPGDKGPP 595

  Fly   355 TAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCV 419
            .......:.....:|.:..||..|:......|                         .||
  Fly   596 PPASTSTLTSQTTTSSSATAEPSAKAAESQAG-------------------------SAG----- 630

  Fly   420 AETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLN 484
                :...||           .|           .|:||.:.  |.|....|....|:.  ||.:
  Fly   631 ----SSGSCS-----------NP-----------AAVHRQRR--LRTPTWARSMSTNKT--RLAD 665

  Fly   485 MRLDEIISKQLEDIFVSDL-----STISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGS 544
            .  |:.:|:...|....::     ||.:.|         :.|.||||.|
  Fly   666 E--DDELSEVQPDAVPPEVREWLASTFTRQ---------MATSRRKSDE---------------- 703

  Fly   545 APTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLE 609
                                   :||.  |...|::|...|..|.     .||.|.:.||:.|
  Fly   704 -----------------------KPKF--RSVAHAIRAGIFVDRM-----YRRVSSSALTAFP-- 736

  Fly   610 APITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSV 674

  Fly   737 ----------------------------------------------------------------- 736

  Fly   675 YSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGM 739
                                           |.::.||.....|.||:|.|.|......:.|:..
  Fly   737 -------------------------------PDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAY 770

  Fly   740 EMFRRFDVFATLNIDENVCKAWLAVIEAHY-RKSNTYHNSTHAADVMQA-------TGAFITQLT 796
            |:|.|:.......|...:.:|:|..:|..| |..|.|||:.||.||||.       || .:..||
  Fly   771 ELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTG-LMNWLT 834

  Fly   797 NKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLG 861
            :        :|...:|:||..||.:|.|.::.|...|....|:||||..|||||||:.:|:| |.
  Fly   835 D--------LEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRL-LR 890

  Fly   862 DDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILM 926
            :|:.||..:|.:|.::..|..:|:|:|.|:||.||:.:.....:...:|      .|.::..:|
  Fly   891 EDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQE------ATIDKQKVL- 948

  Fly   927 RRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFI 991
             .:::...|:|:||:.......|...:.||:|.|.|.||:..||. .|:.||....:.:|||.||
  Fly   949 -SLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPF-SPLCDRNNTLVAESQICFI 1011

  Fly   992 EYIIQDMMHAWESFIDMPQLI 1012
            ::|::..|....   ||.:||
  Fly  1012 DFIVEPSMGVMS---DMLELI 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	18/84 (21%)
		PAS_9	463..539	CDD:290162	18/80 (23%)
		PDEase_I	775..1016	CDD:278654	83/245 (34%)
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	18/107 (17%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	80/240 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020