Protein Alignment Pde8 and Pde9

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Alignment Length: 1181
• Identity: 251/1181 - (21%)
• Similarity: 424/1181 - (35%)
• Gaps: 376/1181 - (31%)

  Fly    16 SSAKSSSSSAGRENPSSEPDSDTEPYAIAIAAISDRSGDNRNERPRPLPDDDSIRS-RLISAAHL 79
            ||::..||||.....::...::|   |.|.||.:..|.           |::::.: .:|:....
  Fly    10 SSSRRGSSSAAAATSTAATAAET---AAAAAATTTSSS-----------DEETLETLTIITTTIT 60

  Fly    80 DLDVGLELASDSTAVPANGGIRPKSEGACPEMKVETISAATSPPPPRPLHGTSGPVAISLPFVGR 144
            |.|:  ...:.:|.|.|:|              ..|.:||.:         |:..:| :|..:..
  Fly    61 DSDI--HATTTTTTVIASG--------------TATTAAAAA---------TTATLA-TLATLAS 99

  Fly   145 NSSKTPEEMELEYEANVEAESR--------DIMTPLRRNTRPLSVSFGGGGG----RSA------ 191
            ||       ::|..:.||:|..        |..|..:..|.|...|...|..    ||:
  Fly   100 NS-------DIEDSSPVESEDSEECEYIEIDCQTTAQEGTSPSGGSSSSGNAVLLQRSSNNLQQQ 157

  Fly   192 ----------LQPEIVEA----IRSLDVPALRLNNLS-FDGS---TDP---KGERNHAEEEPL-- 233
                      ||.::.:|    :|.:...|.|:..|| :.|.   .:|   :.:|...:|..|
  Fly   158 QQQQQQQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQRRQLQEILLRH 222

  Fly   234 ---TPGHDHEDSVVLR----------RKVNC------LERKAHSLYERRLPRVPKLHLLVAGKKN 279
               .||.:|:.::||.          ..::|      :..:|.|...|........|     :::
  Fly   223 SIFDPGKEHQRAIVLAAATAAIAGPLAAIDCVCGSSSISLEAVSSRSRSSELEDDHH-----EQD 282

  Fly   280 PPTEEEEFRTFQRNLMD----LKYPTVLP--------PNPPLKALLVFHKSDSICEAITAACQRH 332
            ...||:|....|.:..|    .::|:..|        |.|.:          ::....||..:|.
  Fly   283 QVQEEQEQEQHQGDTEDNEEEQEHPSEKPERTDIEEEPPPAI----------AVTTTTTATVRRK 337

  Fly   333 QLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNL------------DAEHIARTIRHTH 385
            ....:.:........::..|.:.:|.:        .|.|:            :.:|.:......|
  Fly   338 SSSSSTISGTATVSGSVSVSASASQSF--------CSNNINLLEELLIQFYEEQDHRSNLTVIRH 394

  Fly   386 GHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRC----------------------------VAET 422
            .||        ::....:....|...:...|.|                            .:.|
  Fly   395 HHH--------QQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSGT 451

  Fly   423 TNLAM-------------------CS---VELKQILHSIIRPHNVMSTQQALYTALHR-----LK 460
            ||:.:                   ||   ..|:..||.|...:|  :..:|:  ..||     ..
  Fly   452 TNIHLQPTSLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNN--NCGKAM--PFHRGSCGAAG 512

  Fly   461 EVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRK 525
            |.:|..:.:     |||||          ||              :|:.|.|:   ||..|
  Fly   513 EHLLAANSI-----ANRAT----------II--------------LSKSCSNV---DGDAT---- 541

  Fly   526 SQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSI 590
                             .:|.|.|   ....||.:..|.          ||: .:|..:.|:.:.
  Fly   542 -----------------ATAATAL---SSTVGGGIGGIG----------GSI-KMRASATDIETN 575

  Fly   591 ASDGLRRTSLAKL--------TSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLY 647
            |.:|.|...:|..        .:...|..|.::.|.:.|...|  .|:.|.:   ::.|||:..|
  Fly   576 ALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFN--DDDFRAL---VKDLKRKVEY 635

  Fly   648 SPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELL 712
            :.:|..:            .|...|.....|:||                :|...:.....:|:.
  Fly   636 TERMNWL------------CLSKRPLGPPHRKSS----------------LPKHQEVKRRFLEIC 672

  Fly   713 DESLSWD---------FDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAH 768
            |.:.|.:         ||.::..:.    .:::|...||.........:|..:..:.||..:..|
  Fly   673 DTTFSEEVRAALRLPAFDSYEWSDA----DVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKH 733

  Fly   769 YRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALI---AAAAHDVDHPGRSSAFL 830
            |.:. .:||..|...|.|...| ||:..|    ::.|:.:...||   :...||:||||.::.:.
  Fly   734 YNEV-PFHNFRHCFCVAQMMYA-ITRQAN----LLSRLGDLECLILLVSCICHDLDHPGYNNIYQ 792

  Fly   831 CNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRH 895
            .|:...||:.|||::.|||||.:|.|:| |...:.|||||..::|:.:.|..||..||||:|.||
  Fly   793 INARTELALRYNDISPLENHHCSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARH 856

  Fly   896 FEHLAKFVSVFGGEEPRDHNPQTDEETSI---LMRRMLIKVADVSNPARPMQFCIEWARRIAEEY 957
            .|.|.:|:.:         .|..|.....   |:..:||||||:||.||||.....|..|:.:|:
  Fly   857 NEILTQFMEI---------TPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEF 912

  Fly   958 FMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI-DMPQLIT-------- 1013
            |.|:..||...|| |.|..|....|.|.||:.||..::..:..|....: ::.:||.
  Fly   913 FAQSAAEKSEGLP-VTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALE 976

  Fly  1014 -YMQINYSQWK 1023
             |.::|.:|.|
  Fly   977 YYRRLNDAQTK 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	15/79 (19%)
		PAS_9	463..539	CDD:290162	14/75 (19%)
		PDEase_I	775..1016	CDD:278654	89/256 (35%)
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	86/243 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459135
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.980