Protein Alignment Pde8 and dnc

DIOPT Version :10

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Alignment Length: 1148
• Identity: 252/1148 - (21%)
• Similarity: 418/1148 - (36%)
• Gaps: 313/1148 - (27%)

  Fly    94 VPANGGIRPKSEGACPEMKVETISAATSPPPPRPLHGTSGPVAISLPFVGRNSSKTPEEME-LEY 157
            :|..||     ..|.|         |||||                    :..::||:|:: :..
  Fly    98 LPCRGG-----GSAAP---------ATSPP--------------------QTPAQTPDELKVIPE 128

  Fly   158 EANVEAESRDIMTPLRRN-------TRPLSVS----FGGGGG------------RSALQP----- 194
            :.|:|..:......|.||       .|.:|.|    :||.||            .|...|
  Fly   129 DCNLEKSAEQKRDLLERNNKEDDLLNRTVSGSELDLYGGAGGGTKKHSLADTIDTSVTTPISLKT 193

  Fly   195 -------EIVEAIRSLDVPALRL-----------NNLSFDGSTDP------KGERNHAEEEPLTP 235
                   |:.:.:.:.|:.|..|           ..|| |.|..|      :.::....::||..
  Fly   194 LINDVDEELDQQLSAADIAAASLASGLVARRAEPETLS-DASVSPTAVVQQQQQQQQQLQQPLLQ 257

  Fly   236 GHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGK---------KNP---PTEEEEFR 288
            ...|    .:....|.|.:.  :||....|........|..:         :||   |.:.::..
  Fly   258 SQPH----FVPSSGNILSQV--TLYSGSNPSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRC 316

  Fly   289 TFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQ---LDVTLVKSKEEALDTLQ 350
            :.|            |...||..:....:||........:.:.||   ..:|:......:.:::.
  Fly   317 SCQ------------PQTSPLPHIKEEEESDQANFKHQTSLKEHQPLPPPITIATGYCGSCESVH 369

  Fly   351 KSYATAQCYHLIIIDARSSKNLDAEHIART-----------IRHTHGHHLTTIIAVCKKSFFEKD 404
            .|.||:.....:....:.::    |:||.|           .|..|            ||.:.:
  Fly   370 HSSATSSSAGTVPPGGQQTQ----EYIAGTSSTPSPRIKLKFRKPH------------KSCWSR- 417

  Fly   405 DVLIA-------------LLDAGVNRCVAE--------TTNLAMCSVELKQILHSIIRPHNVMST 448
             :::|             ::.:..|..:|.        ||.....||       |:...|.:.|:
  Fly   418 -IVLAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSV-------SVAAHHRLTSS 474

  Fly   449 QQALYTALHRLKEVVLITD----------DLLRI--QYANRATERLLNMRLD------------- 488
            ..:.....|.....:|.|.          ||.:.  :|.......|.|:|.|
  Fly   475 SASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLEG 539

  Fly   489 ---------EIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVR-------VV 537
                     :.:.::.|.......|......|::.....|.:.|.|.||...:..|       |.
  Fly   540 GSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVT 604

  Fly   538 P----VACIGSAPTHLIFNFDVPG-------GQMDFIATLPQPKEAP------------RGSLHS 579
            |    :|.:.|...:|:...:||.       .|....:....|..||            ..::..
  Fly   605 PFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEE 669

  Fly   580 VRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLS-------QVQEN-CSADEARLIDK 636
            :..|...:.:|.:    ..|::.:.||..:..:.|.::..|       |:.|. ||.    .:||
  Fly   670 LDWCLDQLETIQT----HRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICST----FLDK 726

  Fly   637 VLEFLKREGLYSPQMKEIRTDDPIATDLIGALLT----GPSVYSSRRSSN-------DSIIRTGS 690
            ..||         .:..:|.:|  ..:|:.|...    ....|:..||..       ..:.|..|
  Fly   727 QQEF---------DLPSLRVED--NPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLS 780

  Fly   691 STR--TAAIVPAKMKSNPIIME---LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFAT 750
            .|.  |...:|......|...|   ||.|..:|...||.:.|.:...||..:...:|:..::..:
  Fly   781 HTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTS 845

  Fly   751 LNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDML--VMDRMEEATALI 813
            |.|.......:::.:|.||.|.|.:|||.|||||.|:|..    |.|...|  |...:|...||.
  Fly   846 LMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNV----LLNTPALEGVFTPLEVGGALF 906

  Fly   814 AAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKS 878
            ||..|||||||.::.||.||:..||::|||.:||||||.|:.||| |.:...:||.|:.|:..::
  Fly   907 AACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKL-LQNQGCDIFCNMQKKQRQT 970

  Fly   879 ARSTIIDMILATEMTRHFEHLAKFVSV-----FGGEEPRDHNPQTDEETSILMRRMLIKVADVSN 938
            .|..:||::|:|:|::|...||...::     ..|......:..||.   |.:...|:..||:||
  Fly   971 LRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDR---IQVLENLVHCADLSN 1032

  Fly   939 PARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWE 1003
            |.:|:.....|...:.||:|:|.|:|::..:.| .||.||...:|.|||:|||:||:..:...|.
  Fly  1033 PTKPLPLYKRWVALLMEEFFLQGDKERESGMDI-SPMCDRHNATIEKSQVGFIDYIVHPLWETWA 1096

  Fly  1004 SFI--DMPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQPPVG 1044
            ..:  |...::..::.|...::          :.|....||.|
  Fly  1097 DLVHPDAQDILDTLEENRDYYQ----------SMIPPSPPPSG 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	NtrB	446..>539	CDD:443061	22/137 (16%)
		PDEase_I	775..1016	CDD:459723	93/249 (37%)
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	22/129 (17%)
		PDEase_I	870..1110	CDD:459723	93/248 (38%)