DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde8b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_008758892.1	Gene:	Pde8b / 309962	RGDID:	735041	Length:	885	Species:	Rattus norvegicus

Alignment Length:	990	Identity:	355/990 - (35%)
Similarity:	499/990 - (50%)	Gaps:	175/990 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 STAVPANGGI--RPKSEGACPEMKVETISAATSPPPPRPLHGTSGPVAISLPFVGRNSSKTPEEM 153
            |..|..:|.|  |...|...|..     :::.|..|..||||..
  Rat     6 SIHVSQSGVIYCRDSDESNSPRQ-----TSSVSQGPTAPLHGLF--------------------- 44

  Fly   154 ELEYEANVEAESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALRLNNLSFDGS 218
                   |:.::.|.|.|                .|:|..|..|...||    ...|.:.|..||
  Rat    45 -------VQTDAADAMPP----------------SRAAGPPGAVRVRRS----RAELGSGSSTGS 82

  Fly   219 TDP-----KGERNH----AEEEPLTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLV 274
            :.|     :|.|.|    ||.|..|       |....::|:..|           .|:..:.|
  Rat    83 SGPAATTCRGRRRHCCSSAEAETQT-------SYTSVKQVSSAE-----------VRIGPMRL-- 127

  Fly   275 AGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTLV 339
                   |::                       |::.||:|.|.||..:....||.|......:.
  Rat   128 -------TQD-----------------------PIQVLLIFAKEDSQSDGFWWACDRAGYRCNIA 162

  Fly   340 KSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKD 404
            ::.|.||:.....:     :.:|:||.|.::|.|||.:.|:||.|:....|.|:||..::..:.:
  Rat   163 RTPESALECFLDKH-----HEIIVIDHRQTRNFDAEAVCRSIRATNPSEHTVILAVVSQASDDHE 222

  Fly   405 DV-LIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDD 468
            :. ::.||.||.||...|.:::..|..||.||.|..:|....:....:::|||....|.:.||.|
  Rat   223 EASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSD 287

  Fly   469 LLRIQYANRATERLLNMRLDEIISKQLEDIFVSD------LSTISEQCKNIKEFDGILTVRRKSQ 527
            ...|||.|.|.||::.....|::.|:|.|:..||      |.||:...|..||:.|:...||||.
  Rat   288 DHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSG 352

  Fly   528 EGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKE--------------APRGSLH 578
            :.|..||::.||...|....|.:       .......|....|:              .|....|
  Rat   353 DSIQQHVKITPVIGQGGKIRHFV-------SLKKLCCTTDSSKQIHRIHRDSGDNSQTEPHSFRH 410

  Fly   579 SVRRC-SFDVRSIASDG--------LRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLI 634
            ..||. |.||:||:|.|        .|..|:|::.|:.:||||||:||:::..|||.....|..:
  Rat   411 KSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEAL 475

  Fly   635 DKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVP 699
            |:|||.|:...|||||: ..:.:||..:||:|.|:|.    ..||.|.:..:.|.:...:.:.:.
  Rat   476 DRVLEILRTTELYSPQL-GTKDEDPHTSDLVGGLMTD----GLRRLSGNEYVFTKNVHHSHSHLS 535

  Fly   700 AKMKSN---PIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAW 761
            ..:..|   |.|.:|||...||||:||:||.||...||:|||:::|.||.|...||..|...:||
  Rat   536 MPITINDVPPSIAQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAW 600

  Fly   762 LAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRS 826
            |.||||:|..||.||||||||||:.||..|:.:...|..|  |:::|..|||||..||||||||:
  Rat   601 LQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSL--DQLDEVAALIAATVHDVDHPGRT 663

  Fly   827 SAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATE 891
            ::||||:...|||||||..|||:||.|:.|:||:.|.|.|||||:|:..|::.|..||||:||||
  Rat   664 NSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATE 728

  Fly   892 MTRHFEHLAKFVS-----VFGGEEPRD--HNP--QTDEETSILMRRMLIKVADVSNPARPMQFCI 947
            ||:||||:.|||:     :....|..|  .||  :...|..||::||:||.|||:||.||:..||
  Rat   729 MTKHFEHVNKFVNSINKPLAAESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCI 793

  Fly   948 EWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLI 1012
            |||.||:||||.||||||::.||:|||:|||.|||||||||.||:|.|.||..||::|..:|.|:
  Rat   794 EWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALM 858

  Fly  1013 TYMQINYSQWKKYDE 1027
            .::..||..||..|:
  Rat   859 QHLADNYKHWKTLDD 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	31/85 (36%)
		PAS_9	463..539	CDD:290162	30/81 (37%)
		PDEase_I	775..1016	CDD:278654	140/249 (56%)
Pde8b	XP_008758892.1	PDE8	1..47	CDD:285793	14/73 (19%)
		PAS_9	279..377	CDD:290162	35/104 (34%)
		PAS	284..376	CDD:238075	34/98 (35%)
		PDEase_I	614..861	CDD:278654	140/248 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347785
Domainoid	1	1.000	287	1.000	Domainoid score	I1521
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2758
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1165
OMA	1	1.010	-	-		QHG50014
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm44442
orthoMCL	1	0.900	-	-		OOG6_105168
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910