DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde8 and Pde8a

DIOPT Version :9

Sequence 1:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster
Sequence 2:NP_942062.1 Gene:Pde8a / 308776 RGDID:735125 Length:823 Species:Rattus norvegicus


Alignment Length:839 Identity:313/839 - (37%)
Similarity:461/839 - (54%) Gaps:85/839 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   268 PKLHLLVAGKKNPPTEEEE--------FRTFQR--------------------NLMDLKYPTVLP 304
            |.:|:......||...:.|        .|:.||                    ::.|:::..:..
  Rat     5 PSIHISDNRVSNPSDSDGEDEDVRVPALRSRQRWSTPPGLVEPQPRDSGASKVSVADVQFGPMRF 69

  Fly   305 PNPPLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSS 369
            ....|:.||||.|.||.|.....||::.....|:.|..:..|...|.     :.:.:||||.|:.
  Rat    70 HQDQLQVLLVFTKEDSQCNGFYRACEKAGFKCTVTKEVQTVLACFQD-----KLHDIIIIDHRNP 129

  Fly   370 KNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDV-LIALLDAGVNRCVAETTNLAMCSVELK 433
            :.:|||.:.|:||.:.....|.|:.|.::  .:|::| |:..|.||..|...|..|:..|..||.
  Rat   130 RQMDAEAMCRSIRSSKLSENTVIVGVVRR--VDKEEVSLMPFLAAGFTRRYIENPNVMACYNELL 192

  Fly   434 QILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDI 498
            |:....:|....:....:::|||.:.:|.:.||.:...|||||.|.|..:..:..|:|.|:|..:
  Rat   193 QLAFGEVRSQLKLRACNSVFTALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQV 257

  Fly   499 FVS----DLSTISEQCKNI-KEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGG 558
            .::    ||......|..| ||:.|:...::|:.:.|..:|:::||...|....|.:....|..|
  Rat   258 PINEKKGDLLDAINSCVTIDKEWQGVYHTQKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNG 322

  Fly   559 Q------MDFIATLPQPKEAPRGSLHSVRRCSFDVRSIA------SDGLRRTSLAKLTSLPLEAP 611
            .      .:.:.|..| .::..|.....|:.|.||::::      |:..|.:|||::.|:.:|||
  Rat   323 SNKVETTTECVQTDSQ-TDSQAGKHKDRRKHSMDVKAVSSRTSEVSNQRRHSSLARIHSMMIEAP 386

  Fly   612 ITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYS 676
            |||:||:||..|||........::.||:.|:...|||||..  ..|||.||||:|.|::.    .
  Rat   387 ITKVINILSAAQENSPVSVTEALNHVLDILRTTELYSPQFN--TEDDPHATDLVGGLMSD----G 445

  Fly   677 SRRSSNDSIIRTGSSTRTAA---IVPAKMKS-NPIIMELLDESLSWDFDIFKLEEITDYHPLLYL 737
            .||.|.:.......|.|.::   .||..:.. .|.|.::::....||||||:||..|...||:||
  Rat   446 LRRFSGNEYTLATKSLRPSSSQLAVPISLHDIPPRIAQVIENEEQWDFDIFELEAATQNRPLIYL 510

  Fly   738 GMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLV 802
            |::.|.||::...|...|...|:|..:||::|..||.||||||||||:.||..|:::...||.| 
  Rat   511 GLKTFARFEICEFLQCSEATLKSWFQIIESNYHSSNPYHNSTHAADVLHATAYFLSRNKLKDTL- 574

  Fly   803 MDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINI 867
             ||::|..|||||..||||||||:::||||:...|||||||..|||:||||:.|:|||.:||.||
  Rat   575 -DRLDEVAALIAATIHDVDHPGRTNSFLCNAGKELAVLYNDTAVLESHHAALAFQLTLENDKCNI 638

  Fly   868 FKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTD------------- 919
            |||.|:..|::.|.:||||:||||||:||||:.||::..........|...:             
  Rat   639 FKNTDRNDYRTLRQSIIDMVLATEMTKHFEHVNKFINSINKPLKAQKNEVQETGRSLEDIRAMVR 703

  Fly   920 -EETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSI 983
             .|:..|::||:||.||||||.||::.|||||.||:||||.|||||||..||:|||:|||.||||
  Rat   704 TPESRTLIKRMMIKCADVSNPCRPLEHCIEWAARISEEYFSQTDEEKQLDLPVVMPVFDRNTCSI 768

  Fly   984 PKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQPP 1042
            |||||.||:|.|.||..||::|:.:|.|:.:::.|:..||..||:.:.||     :.||
  Rat   769 PKSQISFIDYFITDMFDAWDAFVYLPNLMRHLEDNFKYWKGLDEKELCTL-----RPPP 822

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde8NP_001163275.2 PAS 459..539 CDD:238075 24/84 (29%)
PAS_9 463..539 CDD:290162 23/80 (29%)
PDEase_I 775..1016 CDD:278654 141/254 (56%)
Pde8aNP_942062.1 PDE8 1..44 CDD:285793 8/38 (21%)
PAS_9 220..318 CDD:290162 28/97 (29%)
PAS 224..318 CDD:238075 27/93 (29%)
PDEase_I 548..801 CDD:278654 141/254 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166347761
Domainoid 1 1.000 287 1.000 Domainoid score I1521
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 534 1.000 Inparanoid score I1165
OMA 1 1.010 - - QHG50014
OrthoDB 1 1.010 - - D80286at33208
OrthoFinder 1 1.000 - - FOG0000302
OrthoInspector 1 1.000 - - otm44442
orthoMCL 1 0.900 - - OOG6_105168
Panther 1 1.100 - - O PTHR11347
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2464
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.910

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