DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and Pde7b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001334295.1	Gene:	Pde7b / 29863	MGIID:	1352752	Length:	498	Species:	Mus musculus

Alignment Length:	338	Identity:	103/338 - (30%)
Similarity:	170/338 - (50%)	Gaps:	40/338 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 MELLDESL------------SWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAW 761
            :.||||..            :||||||..:.:|:.:.|:.|...:|....:.....:|......:
Mouse   146 LHLLDEDYLGQARHMLSKVGTWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRF 210

  Fly   762 LAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ------LTNKDMLVMDRMEEATALIAAAAHDV 820
            |.:::..|...|.|||:.|||||.||...::.:      ||..|:::        .|:|||||||
Mouse   211 LVMVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIML--------GLLAAAAHDV 267

  Fly   821 DHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGD-DKINIFKNLDKETYKSARSTII 884
            ||||.:..||..:|..||.||.:::||||||    ::.|:|. .:..:..:|.||..:.....:.
Mouse   268 DHPGVNQPFLIKTNHHLANLYQNMSVLENHH----WRSTIGMLRESRLLAHLPKEMTQDIEQQLG 328

  Fly   885 DMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEW 949
            .:||||::.|..|.|.:..:....::.|..|.|...    .|.::.:|.||:.||.|..:...:|
Mouse   329 SLILATDINRQNEFLTRLKAHLHNKDLRLENVQDRH----FMLQIALKCADICNPCRIWEMSKQW 389

  Fly   950 ARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFID----MPQ 1010
            :.|:.||::.|.|.|::..|.| .|:.::...|||..||||:.||::.:...|..|..    ...
Mouse   390 SERVCEEFYRQGDLEQKFELEI-SPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSEN 453

  Fly  1011 LITYMQINYSQWK 1023
            :::::..|.:|||
Mouse   454 MLSHLAHNKAQWK 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	81/251 (32%)
Pde7b	NP_001334295.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920