DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde1b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_073201.1	Gene:	Pde1b / 29691	RGDID:	3278	Length:	535	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	128/500 - (25%)
Similarity:	216/500 - (43%)	Gaps:	70/500 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 LRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTD-- 657
            ::..||.:.....||.....|..|...::...|..||..||:..:.|..|    .:::|:|:|
  Rat    32 IKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTE----DELRELRSDAV 92

  Fly   658 DPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKM------KSNPIIMELLDESL 716
            .....|.:.:..|..:....||:......|:......|.|...:|      ...|.....:...|
  Rat    93 PSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTAVGPTYSTAVHNCL 157

  Fly   717 S----WDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYH 776
            .    |.||:|.|....|.|.|..:..|:..|..:.:...|......::|..:|..|.| .|.||
  Rat   158 KNLDVWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYH 222

  Fly   777 NSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLY 841
            |..|||||.|....|:  |....:..:..:|....:.|||.||.:|.|.:::|...:....|:||
  Rat   223 NQIHAADVTQTVHCFL--LRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILY 285

  Fly   842 NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVF 906
            ||.:||||||.:..|:: :.||::|||.||.|:.:...|:.:|:|:|||:|:.||:.:....:..
  Rat   286 NDRSVLENHHISSVFRM-MQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTAL 349

  Fly   907 GGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPI 971
            ...|      :.|:..::   .:|:..||:|:|.:.......|.:.:.||:|.|.|:|.:..||.
  Rat   350 QQLE------RIDKSKAL---SLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPF 405

  Fly   972 VMPMFDRATCSIPKSQIGFIEYIIQDMMHA--------------------------W-ESFIDM- 1008
             .|:.||.:..:.:||||||::|::.....                          | :..:|:
  Rat   406 -SPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLTDDDSKSKSQPSFQWRQPSLDVD 469

  Fly  1009 -----PQLIT-------YMQINYSQWKKYDEQGVNTLAEIMAKQP 1041
                 |.:::       |:|.|..:||:....|:.....|....|
  Rat   470 VGDPNPDVVSFRSTWTKYIQENKQKWKERAASGITNQMSIDELSP 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	79/280 (28%)
Pde1b	NP_073201.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Calmodulin-binding. /evidence=ECO:0000255	27..47		3/14 (21%)
		PDEase_I_N	80..136	CDD:400687	11/59 (19%)
		PDEase_I	221..448	CDD:395177	75/239 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..474		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..535		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850