DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and Pde3b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_058925.2	Gene:	Pde3b / 29516	RGDID:	61943	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	109/376 - (28%)
Similarity:	171/376 - (45%)	Gaps:	70/376 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   705 NPIIME----LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFD---VFATLNIDENVCKAWL 762
            :|:::|    |:::..:|:|.||:|.|.........|...|:..|.   :..|..|.......:.
  Rat   642 DPMLVEDYDSLIEKMSNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYF 706

  Fly   763 AVIEAHYRKSNTYHNSTHAADVMQA-------------------------------TGAFITQLT 796
            ..:|..|| ...|||..||.||:.|                               :...|..|:
  Rat   707 RALENGYR-DIPYHNRVHATDVLHAVWYLTTRPIPGLQQLHNNHETETKADSDARLSSGQIAYLS 770

  Fly   797 NKDMLVMDR-----------MEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENH 850
            :|...:.|:           :|.....:|||.||.|||||::|||..:|...||||||.:|||||
  Rat   771 SKSCCIPDKSYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENH 835

  Fly   851 HAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHN 915
            |||..:.|.|...:.|...|||...:|..|..:|:.||||::.:|||.||:|     ..:..|.|
  Rat   836 HAASAWNLYLSRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFEFLAEF-----NAKANDVN 895

  Fly   916 PQ----TDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMF 976
            ..    :.|...:|:.::.||:||::.||:.....:.|...|..|::.|.|||....||| .|..
  Rat   896 SNGIEWSSENDRLLVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPI-SPFM 959

  Fly   977 DRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDE 1027
            ||::..:.|.|..||.:|:..:.:::::...:|          .||.:.:|
  Rat   960 DRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP----------GQWIEAEE 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	89/286 (31%)
Pde3b	NP_058925.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Interaction with RAPGEF3. /evidence=ECO:0000250	1..32
		DUF3488	145..>264	CDD:403269
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..448
		Interaction with PIK3R6. /evidence=ECO:0000250	421..445
		PDEase_I	718..992	CDD:395177	88/279 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850