DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde6b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001099494.1	Gene:	Pde6b / 289878	RGDID:	1311039	Length:	856	Species:	Rattus norvegicus

Alignment Length:	899	Identity:	184/899 - (20%)
Similarity:	339/899 - (37%)	Gaps:	217/899 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 EEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDT 348
            ||:.|:|            |..||.. |...|.|..| .|.:..||:...| |.....:|  |..
  Rat     5 EEQVRSF------------LDGNPTF-AHQYFEKKLS-PENVAGACEGGCL-VDCGSLRE--LCQ 52

  Fly   349 LQKSYATAQCYHLIIIDARSSKNLDA---EHIAR--TIRHTHGHHL-------------TTIIAV 395
            :::|.|..:    ::.|.:.|.|::.   :.:.|  ||.|.....|             |.:.:|
  Rat    53 VEESAALFE----LVQDMQESVNMERVVFKVLRRLCTILHADRCSLFMYRQRNGVAELATRLFSV 113

  Fly   396 CKKSFFE-----KDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPH------------ 443
            ...|..|     .|..::..||.|:...||:|..:    :.::.:...   ||
  Rat   114 QPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKM----INVQDVAEC---PHFSPFADELTDYV 171

  Fly   444 --NVMSTQ-------QALYTALHRLKEVVLITDDL-LRIQYANRATERLLNMRLDEI-------- 490
              |::||.       .|:..|:::|......::|. :..:|.|.||   ||:::..:
  Rat   172 TKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFAT---LNLKIYHLSYLHNCET 233

  Fly   491 ------------ISKQLEDI---FVSDLSTISEQCKNIKEFDGILTVRRKSQ----------EGI 530
                        :.::|.||   |.....|:.......:...|:|.:.::.:          |..
  Rat   234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQ 298

  Fly   531 P---------------------MH----VRVVPV------ACIGSAPTHLIFNFDVPGGQMDFIA 564
            |                     :|    ::|:|.      |.....||::
  Rat   299 PYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPPADHWALTSGLPTYV--------------- 348

  Fly   565 TLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTS---LAKLTSLPLEAPITKIINLLSQVQEN- 625
                   |..|.:.::...|.|......:|....|   :..:.|:|:.....:|:.:.:.....
  Rat   349 -------AESGFICNIMNASADEMFNFQEGPLDESGWVIKNVLSMPIVNKKEEIVGVATFYNRKD 406

  Fly   626 ----CSADEARLIDKVLEFLKREGLYS---PQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSND 683
                ...||. |::.:.:||....|.:   .:|.::.....||.|::        :|.. |...|
  Rat   407 GKPFDDQDEV-LMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMV--------LYHV-RCDKD 461

  Fly   684 SIIRTGSSTRTAAIVPAKMKSNPIIMELLDESL--SWDFDIFKLE----EITDYHPLLYLGMEMF 742
            .|.....:.......||..:.:. :.::|.|.|  ...|||::..    |.|:.. |:..|::|:
  Rat   462 EIQEILPTRDRLGKEPADCEEDE-LGKILKEELPGPTKFDIYEFHFSDLECTELE-LVKCGIQMY 524

  Fly   743 RRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRME 807
            ....|.....|.:.|...:|..:...||:. ||||..|..:|.|.  .|...:|.|.......:|
  Rat   525 YELGVVRKFQIPQEVLVRFLFSVSKAYRRI-TYHNWRHGFNVAQT--MFTLLMTGKLKSYYTDLE 586

  Fly   808 EATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITF-KLTLGDDKINIFKNL 871
            ....:.|...||:||.|.::.:...|.:.||.|:.. ::||.||  :.| |..|.::.:||::||
  Rat   587 AFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS-SILERHH--LEFGKFLLAEESLNIYQNL 648

  Fly   872 DKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSI------LMRRML 930
            ::..::.....:...|:||::..:|:....|..:....:..:......|..|:      ::..|:
  Rat   649 NRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMM 713

  Fly   931 IKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ--RHLPIVMPMFDR-ATCSIPKSQIGFIE 992
            :...|:|...:|.:...:.|..:|.|::.|.|.|:.  ...||  ||.|| ....:||.|:|||:
  Rat   714 MTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPI--PMMDRNKAAELPKLQVGFID 776

  Fly   993 YIIQDMMHAWESFID--MPQLITYMQINYSQWK----KYDEQGVNTLAEIMAKQ 1040
            ::...:...:..|.:  :| :...:|.|..:||    :| |..|..|.|...|:
  Rat   777 FVCTFVYKEFSRFHEEILP-MFDRLQNNRKEWKALADEY-EAKVKALEEEKKKE 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	19/138 (14%)
		PAS_9	463..539	CDD:290162	18/134 (13%)
		PDEase_I	775..1016	CDD:278654	62/252 (25%)
Pde6b	NP_001099494.1	GAF	71..230	CDD:214500	32/168 (19%)
		GAF	252..439	CDD:214500	29/209 (14%)
		PDEase_I	556..801	CDD:278654	62/252 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850