DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and PDE7B

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_061818.1	Gene:	PDE7B / 27115	HGNCID:	8792	Length:	450	Species:	Homo sapiens

Alignment Length:	427	Identity:	119/427 - (27%)
Similarity:	194/427 - (45%)	Gaps:	80/427 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   670 TGPSVYSSRRSSNDSI-IRTGSSTRTAAIVPAKMKSNPII--------------------MELLD 713
            ||  |.:.||.|...| .|..:||..:..:..|.|...::                    :.|||
Human    36 TG--VRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLD 98

  Fly   714 ES--------LS----WDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIE 766
            |.        ||    ||||||..:.:|:.:.|:.|...:|....:.....:|......:|.:::
Human    99 EDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQ 163

  Fly   767 AHYRKSNTYHNSTHAADVMQATGAFITQ------LTNKDMLVMDRMEEATALIAAAAHDVDHPGR 825
            ..|...|.|||:.|||||.||...::.:      ||..|:::        .|:|||||||||||.
Human   164 EDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIML--------GLLAAAAHDVDHPGV 220

  Fly   826 SSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGD-DKINIFKNLDKETYKSARSTIIDMILA 889
            :..||..:|..||.||.:::||||||    ::.|:|. .:..:..:|.||..:.....:..:|||
Human   221 NQPFLIKTNHHLANLYQNMSVLENHH----WRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILA 281

  Fly   890 TEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIA 954
            |::.|..|.|.:..:....::.|    ..|.:....|.::.:|.||:.||.|..:...:|:.|:.
Human   282 TDINRQNEFLTRLKAHLHNKDLR----LEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVC 342

  Fly   955 EEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFID----MPQLITYM 1015
            ||::.|.:.|::..|.| .|:.::...|||..||||:.||::.:...|..|..    ...::.::
Human   343 EEFYRQGELEQKFELEI-SPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHL 406

  Fly  1016 QINYSQWKK-----------------YDEQGVNTLAE 1035
            ..|.:|||.                 :|..|..|.:|
Human   407 AHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESE 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	79/251 (31%)
PDE7B	NP_061818.1	PDEase_I	172..392	CDD:278654	78/236 (33%)
PDE7B	NP_061818.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..450		4/26 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154176
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850