DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde4a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_037233.4	Gene:	Pde4a / 25638	RGDID:	3279	Length:	844	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	150/536 - (27%)
Similarity:	239/536 - (44%)	Gaps:	94/536 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 VRRKSQEGIPMHVR---VVPVACIGSAPTHLIFNF----DVPGGQMDFIATLPQPKEAPRGSLHS 579
            |.|.|......|..   |.|.|.:.::...:..||    :||         :|..|.:|.|...|
  Rat   156 VSRSSSVASEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP---------IPSNKRSPLGGPPS 211

  Fly   580 VRRCSF------------------------------DVRSIASDGLRRTSLAKLTSLPLEAPITK 614
            |.:.:.                              .|..:||...:|....:||.|   :.:::
  Rat   212 VCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHL---SEMSR 273

  Fly   615 IINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRR 679
            ..|.:|:...|...|:...::......::.....|....:|...|::.      :||..
  Rat   274 SGNQVSEYISNTFLDKQNEVEIPSPTPRQRAFQQPPPSVLRQSQPMSQ------ITGLK------ 326

  Fly   680 SSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRR 744
                .::.|||..........|.....::.:.|:....|..:||.:.|......|..:...:|:.
  Rat   327 ----KLVHTGSLNTNVPRFGVKTDQEDLLAQELENLSKWGLNIFCVSEYAGGRSLSCIMYTIFQE 387

  Fly   745 FDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEA 809
            .|:....:|..:....::..:|.||.....||||.|||||:|:|...:.  |.....|...:|..
  Rat   388 RDLLKKFHIPVDTMMMYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLA--TPALDAVFTDLEIL 450

  Fly   810 TALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKE 874
            .||.|||.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |.::..:||:||.|.
  Rat   451 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKL-LQEENCDIFQNLSKR 514

  Fly   875 TYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS------------ILMR 927
            ..:|.|..:|||:|||:|::|...||...::.          :|.:.||            |.:.
  Rat   515 QRQSLRKMVIDMVLATDMSKHMTLLADLKTMV----------ETKKVTSSGVLLLDNYSDRIQVL 569

  Fly   928 RMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIE 992
            |.::..||:|||.:|::...:|..||..|:|.|.|.|::|.:.| .||.|:.|.|:.|||:|||:
  Rat   570 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEI-SPMCDKHTASVEKSQVGFID 633

  Fly   993 YIIQDMMHAWESFIDM 1008
            ||:..:   ||::.|:
  Rat   634 YIVHPL---WETWADL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	5/19 (26%)
		PAS_9	463..539	CDD:290162	5/19 (26%)
		PDEase_I	775..1016	CDD:278654	101/246 (41%)
Pde4a	NP_037233.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		PDE4_UCR	173..288	CDD:407935	23/126 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..317		2/20 (10%)
		PDEase_I	418..659	CDD:395177	101/246 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..690
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850