Protein Alignment Pde8 and Pde4b

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_038965199.1
• Gene: Pde4b / 24626
• RGDID: 3280
• Length: 736
• Species: Rattus norvegicus
• Alignment Length: 615
• Identity: 162/615 - (26%)
• Similarity: 260/615 - (42%)
• Gaps: 173/615 - (28%)

  Fly   503 LSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLP 567
            ::|:|::|.::              |..|...| .|:....|:.:.|:.:...||
  Rat    87 ITTVSQECFDV--------------ENGPSPGR-SPLDPQASSSSGLVLHAAFPG---------- 126

  Fly   568 QPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLE----------------------- 609
                      ||.||.||..||.:...|...::::.:|||.|
  Rat   127 ----------HSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN 181

  Fly   610 ---------------------APITKI---------------------------INLLSQVQENC 626
                                 ||:|::                           |.....|.|..
  Rat   182 NFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMA 246

  Fly   627 SADEARLIDKVLEFL---KREG-------------------LYSPQMK--EIRTDDPIATDLIGA 667
            |....|::::.|..|   .|.|                   :.||..|  |.:....:.|.:.|.
  Rat   247 SNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGV 311

  Fly   668 LLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYH 732
                ..:..|...:|.||.|.|.:|          ::...:.:.|::...|..:||.:...:...
  Rat   312 ----KKLMHSSSLNNTSISRFGVNT----------ENEDHLAKELEDLNKWGLNIFNVAGYSHNR 362

  Fly   733 PLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTN 797
            ||..:...:|:..|:..|..|..:....::..:|.||.....||||.|||||.|:|...::  |.
  Rat   363 PLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLS--TP 425

  Fly   798 KDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGD 862
            ....|...:|...|:.|||.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |.:
  Rat   426 ALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKL-LQE 489

  Fly   863 DKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS---- 923
            :..:||:||.|:..::.|..:|||:|||:|::|...||...::.          :|.:.||
  Rat   490 EHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMV----------ETKKVTSSGVL 544

  Fly   924 --------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRAT 980
                    |.:.|.::..||:|||.:.::...:|..||.||:|.|.|:|::|.:.| .||.|:.|
  Rat   545 LLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI-SPMCDKHT 608

  Fly   981 CSIPKSQIGFIEYIIQDMMHAWESFIDMPQ 1010
            .|:.|||:|||:||:..:   ||::.|:.|
  Rat   609 ASVEKSQVGFIDYIVHPL---WETWADLVQ 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	6/35 (17%)
		PAS_9	463..539	CDD:290162	6/35 (17%)
		PDEase_I	775..1016	CDD:278654	100/248 (40%)
Pde4b	XP_038965199.1	PDE4_UCR	166..281	CDD:407935	12/114 (11%)
		PDEase_I	405..646	CDD:395177	100/248 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920