Protein Alignment Pde8 and Pde11a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_006499516.1
• Gene: Pde11a / 241489
• MGIID: 3036251
• Length: 1011
• Species: Mus musculus
• Alignment Length: 980
• Identity: 208/980 - (21%)
• Similarity: 340/980 - (34%)
• Gaps: 261/980 - (26%)

  Fly   172 LRRNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALRLNNL----SFDGSTDPKGERNHAEEEP 232
            |:|:|        .|.|.|:|:|.:..|      .:|..:|.    ...|...|:|.   |...|
Mouse    39 LQRHT--------SGQGASSLRPALAGA------SSLAQSNAKGSPGIGGGAGPQGS---AHSHP 86

  Fly   233 LTPGHDHEDSVVL-------RRKVNCLERKAHSLYERR-LPRVPKLHL------LVAGKKNPPTE 283
             |||......|.|       .|....|:|:|.....|: ..|...:|:      .|..:...|..
Mouse    87 -TPGGGESAGVPLSPSWASGSRGDGSLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLS 150

  Fly   284 EEEFRTFQRNLMDLKYPTV-------------LPPNPPLKALLVFHKSDSICEAITAAC--QRH- 332
            ....|...|....|. ||.             ||..||              .||...|  ::|
Mouse   151 SVRRRALLRKASSLP-PTTAHILSALLESRVNLPQYPP--------------TAIDYKCHLKKHN 200

  Fly   333 --QLDVTLVKSKEEALDTLQKSY---------ATAQCYHLIIIDARS-------SKNLDAEHIAR 379
              |..:.|||.....||....||         ..|....|.:::..:       ||..|.
Mouse   201 ERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDV----- 260

  Fly   380 TIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCV---AETTNL--------------AM 427
                    |..|.:..|..:  |..:.:......|:...|   .||.|:              .:
Mouse   261 --------HAGTPLLPCSST--ENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKL 315

  Fly   428 CSVELKQILHSIIRPHN--VMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEI 490
            ...:.|.:|...||..:  ::...|    |::::.|....|:|          .|:::.|.|
Mouse   316 TGYKTKSLLCMPIRNSDGEIIGVAQ----AINKVPEGAPFTED----------DEKVMQMYL--- 363

  Fly   491 ISKQLEDIFVSDLSTISEQCKNIKEFDGILTV------RRKSQEGIP---MHVRVVPVACIGSAP 546
               ....|.:|:....:...|..:....:|.|      .:...|.|.   ||.....:.| ....
Mouse   364 ---PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC-ERCS 424

  Fly   547 THLIFNFDVPGGQMDFIATLPQPK---EAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKL---TS 605
            ..|:.:.:.|..:......|..||   :|......||.:.|:      ||.|...|:|:|   |.
Mouse   425 VLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESVEKSSY------SDWLINNSIAELVASTG 483

  Fly   606 LPLEAP-------------------------------------ITKIINLLSQVQENCSADEA-- 631
            ||:...                                     :.:::|.|    :....|:|
Mouse   484 LPVNVSDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL----DGKPFDDADQ 544

  Fly   632 RLIDKVLEF----LKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSST 692
            ||.:..:.|    :....:|. |:|:......:|.|::.        |.:..|.
Mouse   545 RLFEAFVIFCGLGINNTIMYD-QVKKSWAKQSVALDVLS--------YHATCSK----------- 589

  Fly   693 RTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNID-EN 756
              |.:...|..:.|::.||..:.:  .||.|.|    |...::...:.||....:.....|| |.
Mouse   590 --AEVDKFKAANIPLVSELAIDDI--HFDDFSL----DVDAMITAALRMFMELGMVQKFKIDYET 646

  Fly   757 VCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVD 821
            :|: ||..:..:||.. .|||..||.:|.|...|.:|....:::|.  .:|....::....||:|
Mouse   647 LCR-WLLTVRKNYRMV-LYHNWRHAFNVCQLMFAMLTTAGFQEILT--EVEILAVIVGCLCHDLD 707

  Fly   822 HPGRSSAFLCNSNDALAVLYNDLTVLENHH--AAITFKLTLGDDKINIFKNLDKETYKSARSTII 884
            |.|.::||...|:.|||.||.....||:||  .|:   :.|..:..|||.||..:.|......:.
Mouse   708 HRGTNNAFQAKSDSALAQLYGTSATLEHHHFNHAV---MILQSEGHNIFANLSSKEYSDLMQLLK 769

  Fly   885 DMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSI-----LMRRMLIKVADVSNPARPMQ 944
            ..||||::|.:||...:|..:.         .:.|.:.||     :.|.||:...|:....:|.:
Mouse   770 QSILATDLTLYFERRTEFFELV---------RKGDYDWSITSHRDVFRSMLMTACDLGAVTKPWE 825

  Fly   945 FCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESFIDM 1008
            ...:.|..:..|:|.|.|.|:.........:||| ....:|:.|:.:|:.|...:..:..|.|..
Mouse   826 ISRQVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQSIGSNIRG 890

  Fly  1009 PQLIT 1013
            |:.:|
Mouse   891 PEFLT 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	15/88 (17%)
		PAS_9	463..539	CDD:290162	14/84 (17%)
		PDEase_I	775..1016	CDD:278654	69/247 (28%)
Pde11a	XP_006499516.1	GAF	217..380	CDD:214500	31/197 (16%)
		GAF	402..568	CDD:214500	32/177 (18%)
		PDEase_I	663..885	CDD:365964	65/235 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840