DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde10a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_017172949.1	Gene:	Pde10a / 23984	MGIID:	1345143	Length:	891	Species:	Mus musculus

Alignment Length:	1077	Identity:	215/1077 - (19%)
Similarity:	350/1077 - (32%)	Gaps:	364/1077 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PRPLHGTSGPVAISLPFVGRNSSKTPEEMELEYEANVEAESRDIMTPLRRNTRPLSVSFGGGGGR 189
            |....|.|......|||..:..||.|..:.|..    ..:||..|:  ..:|.....|....|||
Mouse    21 PTAWFGGSSEEPGCLPFALKGGSKGPALLALRN----RTDSRGQMS--NDSTEGTVGSCNATGGR 79

  Fly   190 SALQPEIVEAIRSLDVPALRLNNLSF-DGSTDPKGERNHAEEEPLTPGHDHEDSVVLRRKVNCLE 253
            ....|:                 |.| .|..|.|||..
Mouse    80 GQSLPQ-----------------LCFPPGPHDTKGEYG--------------------------- 100

  Fly   254 RKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHK- 317
                ::::|         |..|.||      ||   |.|.|.|.|          :||.|..|.
Mouse   101 ----AVFQR---------LSSAQKK------EE---FTRGLTDEK----------VKAYLSLHPQ 133

  Fly   318 --SDSICEAITAACQRHQLDVTLVKSKEE----ALDTLQKSYATAQCYHL-IIIDARSSKNLDAE 375
              .:.:.|:::|......|.....|:|:|    .:...|.:......|.| ..|:.|.....|
Mouse   134 VLDEFVSESVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGD-- 196

  Fly   376 HIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSII 440
                  .|...:.|::||.:..|:    |...:..|    ..|     |.::|          :.
Mouse   197 ------NHLLLYELSSIIRIATKA----DGFALYFL----GEC-----NNSLC----------VF 232

  Fly   441 RPHNVMSTQQAL--------------YTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEII 491
            .|..:...|..|              |.|..|   ..|:.:|:|..:...|.|......|:..::
Mouse   233 IPPGMKEGQPRLIPAGPITQGTTISAYVAKSR---KTLLVEDILGDERFPRGTGLESGTRIQSVL 294

  Fly   492 SKQLEDIFVSDLSTISEQCKNIKEFDGILTV-RRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDV 555
            .          |..::.    |.:..|||.: |...:|...:..:.|..|.:..|..
Mouse   295 C----------LPIVTA----IGDLIGILELYRHWGKEAFCLSHQEVATANLAWASV-------- 337

  Fly   556 PGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLP---LEAPITKIIN 617
                                ::|.|:.|              ..|||.|.|.   |:...|...|
Mouse   338 --------------------AIHQVQVC--------------RGLAKQTELNDFLLDVSKTYFDN 368

  Fly   618 LLSQVQENCSADEARLIDKVLEFL--------------------KREGLYS-------------- 648
            :::             ||.:||.:                    |.:.|||
Mouse   369 IVA-------------IDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPI 420

  Fly   649 -PQMKEIR--TDDPIATDL--IGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPI- 707
             .:.||||  .:..||..:  .|.:|..|..|:..|.:.:..:.||.:||....:|...:.:.|
Mouse   421 FKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIG 485

  Fly   708 IMELL-----------DESLSWDFDIF-----------------------KLEEITDYHPLL--- 735
            :::::           ||:....|.:|                       .:|::: ||.:.
Mouse   486 VVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS-YHSICTSE 549

  Fly   736 -YLGMEMFR------------RFDVFATLNI-------------------DENVCKAWLAVIEAH 768
             :.|:..|.            .||:....|:                   .|.:|: ::..::.:
Mouse   550 EWQGLMRFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCR-FIMSVKKN 613

  Fly   769 YRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNS 833
            ||:. .|||..||..|.....|.   |.|.:.|..| :|....|||...||:||.|.|:::|...
Mouse   614 YRRV-PYHNWKHAVTVAHCMYAI---LQNNNGLFTD-LERKGLLIACLCHDLDHRGFSNSYLQKF 673

  Fly   834 NDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEH 898
            :..||.||:..| :|.||.:.|..: |..:..|||..|....|:.....|...|:||::..:|.:
Mouse   674 DHPLAALYSTST-MEQHHFSQTVSI-LQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGN 736

  Fly   899 LAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDE 963
            ..:...::.......|| |:..:..|   .:::...|:.:..:........|..|..|::.:.||
Mouse   737 RKQLEEMYQTGSLNLHN-QSHRDRVI---GLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDE 797

  Fly   964 EKQRHL-PIVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQI--------- 1017
            .|:..: ||  ||.|| ....:|:.|:||.            :.:.:|...|..||
Mouse   798 MKKLGIQPI--PMMDRDKRDEVPQGQLGFY------------NAVAIPCYTTLTQILPPTEPLLK 848

  Fly  1018 ----NYSQWKKYDEQGVNTLAEIMAKQPPVGKMANSK 1050
                |.:||:|. .:|..|...|....|...|....|
Mouse   849 ACRDNLNQWEKV-IRGEETAMWISGPGPAPSKSTPEK 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	14/80 (18%)
		PAS_9	463..539	CDD:290162	14/76 (18%)
		PDEase_I	775..1016	CDD:278654	65/242 (27%)
Pde10a	XP_017172949.1	GAF	196..339	CDD:376570	33/218 (15%)
		GAF	372..527	CDD:214500	29/154 (19%)
		PDEase_I	619..851	CDD:365964	67/255 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920