DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde4d

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_006517706.1	Gene:	Pde4d / 238871	MGIID:	99555	Length:	803	Species:	Mus musculus

Alignment Length:	576	Identity:	162/576 - (28%)
Similarity:	259/576 - (44%)	Gaps:	127/576 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   553 FDVPGGQMDFIATLPQPKEAPRGSL-------HSVRRCSFDVR----------------SIASD- 593
            |||..|.....:.| .|..:|...|       ||.||.||..|                |||||
Mouse   148 FDVDNGTSAGRSPL-DPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDI 211

  Fly   594 ---------------GLR--RTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFL 641
                           .||  |.:.|.||:|...||..:     |.:....|.::|.:.::..:.|
Mouse   212 HGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKR-----SPMCNQPSINKATITEEAYQKL 271

  Fly   642 KREGLYS-----PQMKEIRTDDPI---ATDLIGALLTGPSVYSSR--RSSN---DSIIRT----- 688
            ..|.|..     .|::.::|...:   |::....:|.....:.|.  ||.|   :.|..|
Mouse   272 ASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQ 336

  Fly   689 ------------------------------GSSTRTAAIVP---AKMKSNPIIMELLDESLSWDF 720
                                          .||:.|.:.:|   .|.:...::.:.|::...|..
Mouse   337 HEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGL 401

  Fly   721 DIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVM 785
            .:|::.|::...||..:...:|:..|:..|..|..:....:|..:|.||.....|||:.|||||:
Mouse   402 HVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVV 466

  Fly   786 QATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENH 850
            |:|...::  |.....|...:|...|:.|:|.|||||||.|:.||.|:|..||::|||.:|||||
Mouse   467 QSTHVLLS--TPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENH 529

  Fly   851 HAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHN 915
            |.|:.||| |.::..:||:||.|:..:|.|..:||::|||:|::|...||...::.
Mouse   530 HLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV--------- 584

  Fly   916 PQTDEETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRH 968
             :|.:.||            |.:.:.::..||:|||.:|:|...:|..||.||:|.|.|.|::|.
Mouse   585 -ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERG 648

  Fly   969 LPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQINYSQW 1022
            :.| .||.|:...|:.|||:|||:||:..:...|...:  |...::..::.| .:|
Mouse   649 MEI-SPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN-REW 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	96/254 (38%)
Pde4d	XP_006517706.1	PDE4_UCR	218..334	CDD:375549	25/120 (21%)
Pde4d	XP_006517706.1	PDEase_I	456..697	CDD:365964	96/254 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850