DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde6a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_666198.1	Gene:	Pde6a / 225600	MGIID:	97524	Length:	860	Species:	Mus musculus

Alignment Length:	850	Identity:	184/850 - (21%)
Similarity:	322/850 - (37%)	Gaps:	198/850 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 DVTLVKSKEEALDTL---QKSYATAQC--------YHLIIIDARS-----SKNLDAEHIARTIRH 383
            ||..|:..|...|.|   |::....:|        ..|:..|..|     ::|..|| :|..:.:
Mouse    51 DVNSVEESEIIFDLLRDVQENLQAEKCTFNVMKKLCFLLRADRMSLFMYRTRNGIAE-LATRLFN 114

  Fly   384 THGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAETTNLA-MCSVELKQILHSIIRPHNVMS 447
            .|..      ||.:......|..::..||.||...||.:..:| :.:.|..:.....:.......
Mouse   115 VHKD------AVLEDCLVMPDSEIVFPLDMGVVGHVAHSKKIANVPNTEEDEHFCDFVDNLTEYQ 173

  Fly   448 TQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLE---------------- 496
            |:..|.:.:...|:||.|      |...|:..|.....|.:||:.|.|.
Mouse   174 TKNILASPIMNGKDVVAI------IMAVNKIDEPHFTKRDEEILLKYLNFVNLIMKVFHLSYLHN 232

  Fly   497 ------DIFVSDLSTISEQCKNI-KEF-DGILTVR---------------RKSQEGIPMHVRVVP 538
                  .|.:...|.:.|:..:| ::| ..:.|||               .|.:|    ...|.|
Mouse   233 CETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKE----FFDVWP 293

  Fly   539 VACIGSAPTHLIFNFDVP----GGQMDF-------------IATLPQPKEAPRGSLHSVRRCSFD 586
            | .:|.||.     :..|    |.:::|             |..:|.| .|...:|     .|..
Mouse   294 V-LMGEAPA-----YSGPRTPDGREINFYKVIDYILHGKEDIKVIPNP-PADHWAL-----VSGL 346

  Fly   587 VRSIASDGLRRTSLAKLTSLPLE-------APITK----IINLLSQVQENCSADEARLIDKVLEF 640
            ...:|.:||    :..:.:.|.|       .|:.:    |.|:||....|   .:..::.....:
Mouse   347 PTYVAQNGL----ICNIMNAPAEDFFEFQKEPLDESGWMIKNVLSMPIVN---KKEEIVGVATFY 404

  Fly   641 LKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSR------------------RSSNDSIIR 687
            .:::|.....|.|...:.  .|..:|..:..|..|.|.                  :..|:.|.:
Mouse   405 NRKDGKPFDDMDETLMES--LTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQK 467

  Fly   688 TGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYH----PLLYL-----GMEMFR 743
            ...:.......|.:.:.     |.|.|.|..:....:..||..:|    ||..|     |::|:.
Mouse   468 ILKTREVYGKEPWECEE-----EELAEILQGELPDAESYEINKFHFSDLPLTELELVKCGIQMYY 527

  Fly   744 RFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRME- 807
            ...|....:|.:.....::..:...||:. ||||..|..:|.|         |...:||..:::
Mouse   528 ELRVVDKFHIPQEALVRFMYSLSKGYRRI-TYHNWRHGFNVGQ---------TMFSLLVTGKLKR 582

  Fly   808 -----EATALIAAA-AHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITF-KLTLGDDKI 865
                 ||.|::.|| .||:||.|.::.:...|.:.||.|:.. ::||.||  :.| |..|.|:.:
Mouse   583 YFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGS-SILERHH--LEFGKTLLRDESL 644

  Fly   866 NIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILM---- 926
            |||:||::..::.|...:...|:||::..:|:....|..:....:..:   .|.|.|..:|
Mouse   645 NIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYE---STQEWTQYMMLEQT 706

  Fly   927 -----RRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ--RHLPIVMPMFDRATC-SI 983
                 ..|::...|:|...:|.:...:.|..:|.|::.|.|.|:.  :..||  ||.||... .:
Mouse   707 RKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPI--PMMDRNKADEL 769

  Fly   984 PKSQIGFIEYIIQDMMHAWESF-IDMPQLITYMQINYSQWK----KYDEQGVNTLAEIMAKQPPV 1043
            ||.|:|||:::...:...:..| .::..::..:..|..:||    :| |..:..|.|...||...
Mouse   770 PKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEY-EAKMKALEEEKQKQQAA 833

  Fly  1044 GKMAN 1048
            .:.|:
Mouse   834 KQAAS 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	23/118 (19%)
		PAS_9	463..539	CDD:290162	21/114 (18%)
		PDEase_I	775..1016	CDD:278654	69/261 (26%)
Pde6a	NP_666198.1	GAF	67..232	CDD:214500	35/177 (20%)
		GAF	254..441	CDD:214500	41/211 (19%)
		PDEase_I	558..802	CDD:278654	69/260 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850