DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde8b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001360932.1	Gene:	Pde8b / 218461	MGIID:	2443999	Length:	885	Species:	Mus musculus

Alignment Length:	1003	Identity:	358/1003 - (35%)
Similarity:	505/1003 - (50%)	Gaps:	189/1003 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 STAVPANGGI--RPKSEGACPEMKVETISAATSPPPPRPLHGTSGPVAISLPFVGRNSSKTPEEM 153
            |..|..:|.|  |...|...|..     :::.|..|..||||..
Mouse     6 SIHVSQSGVIYCRDSDESNSPRQ-----TSSVSQGPTAPLHGLF--------------------- 44

  Fly   154 ELEYEANVEAESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALRLNNLSFDGS 218
                   |:.::.|.|.|                .|:|..|..|...||    ...|.:.|..||
Mouse    45 -------VQTDAADAMPP----------------SRAAGPPGAVRVRRS----RAELGSGSSTGS 82

  Fly   219 TDP-----KGERNH----AEEEPLTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLV 274
            :.|     :|.|.|    ||.|..|       |....::|:..|           .|:..:.|
Mouse    83 SGPATTTCRGRRRHCCSSAEAETQT-------SYTSVKQVSSAE-----------VRIGPMRL-- 127

  Fly   275 AGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTLV 339
                   |::                       |::.||:|.|.||..:....||.|......:.
Mouse   128 -------TQD-----------------------PIQVLLIFAKEDSQSDGFWWACDRAGYRCNIA 162

  Fly   340 KSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKD 404
            ::.|.||:.....:     :.:|:||.|.|:|.|||.:.|:||.|:....|.|:||..::..:.:
Mouse   163 RTPESALECFLDKH-----HEIIVIDHRQSRNFDAEAVCRSIRATNPSEHTVILAVVSQASDDHE 222

  Fly   405 DV-LIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDD 468
            :. ::.||.||.||...|.:::..|..||.||.|..:|....:....:::|||....|.:.||.|
Mouse   223 EASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSD 287

  Fly   469 LLRIQYANRATERLLNMRLDEIISKQLEDIFVSD------LSTISEQCKNIKEFDGILTVRRKSQ 527
            ...|||.|.|.||::.....|::.|:|.|:..||      |.||:...|..||:.|:...||||.
Mouse   288 DHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSG 352

  Fly   528 EGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQ---------------------PKE 571
            :.|..||::.||  ||.            ||::....:|.:                     .:.
Mouse   353 DSIQQHVKITPV--IGQ------------GGKIRHFVSLKKLCCTTDSNKQIHRIHRDSGDNSQT 403

  Fly   572 APRGSLHSVRRC-SFDVRSIASDG--------LRRTSLAKLTSLPLEAPITKIINLLSQVQENCS 627
            .|....|..||. |.||:||:|.|        .|..|:|::.|:.:||||||:||:::..|||..
Mouse   404 EPHSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSP 468

  Fly   628 ADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSST 692
            ...|..:|:|||.|:...|||||: ..:.:||..:||:|.|:|.    ..||.|.:..:.|.:..
Mouse   469 VTVAEALDRVLEILRTTELYSPQL-GTKDEDPHTSDLVGGLMTD----GLRRLSGNEYVFTKNVH 528

  Fly   693 RTAAIVPAKMKSN---PIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNID 754
            .:.:.:...:..|   |.|.:|||...||||:||:||.:|...||:|||:::|.||.|...||..
Mouse   529 HSHSHLSMPITINDVPPSIAQLLDNEESWDFNIFELEAVTHKRPLVYLGLKVFSRFGVCEFLNCT 593

  Fly   755 ENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHD 819
            |...:|||.||||:|..||.||||||||||:.||..|:.:...|..|  |:::|..|||||..||
Mouse   594 ETTLRAWLQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSL--DQLDEVAALIAATVHD 656

  Fly   820 VDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTII 884
            ||||||:::||||:...|||||||..|||:||.|:.|:||:.|.|.|||||:|:..|::.|..||
Mouse   657 VDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 721

  Fly   885 DMILATEMTRHFEHLAKFVS-----VFGGEEPRD--HNP--QTDEETSILMRRMLIKVADVSNPA 940
            ||:||||||:||||:.|||:     :....|..|  .||  :...|..||::||:||.|||:||.
Mouse   722 DMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPC 786

  Fly   941 RPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESF 1005
            ||:..|||||.||:||||.||||||::.||:|||:|||.|||||||||.||:|.|.||..||::|
Mouse   787 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAF 851

  Fly  1006 IDMPQLITYMQINYSQWKKYDEQGVNTL 1033
            ..:|.|:.::..||..||..|:....||
Mouse   852 AHLPALMQHLADNYKHWKTLDDLKCKTL 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	31/85 (36%)
		PAS_9	463..539	CDD:290162	30/81 (37%)
		PDEase_I	775..1016	CDD:278654	140/249 (56%)
Pde8b	NP_001360932.1	PDE8	1..47	CDD:285793	14/73 (19%)
		PAS	167..375	CDD:225112	73/226 (32%)
		PAS_9	280..377	CDD:379177	37/110 (34%)
		PDEase_I	614..861	CDD:365964	140/248 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844415
Domainoid	1	1.000	286	1.000	Domainoid score	I1596
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2758
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1182
Isobase	1	0.950	-	0	Normalized mean entropy	S4025
OMA	1	1.010	-	-		QHG50014
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm42380
orthoMCL	1	0.900	-	-		OOG6_105168
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890