Protein Alignment Pde8 and Pde2a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_006507586.1
• Gene: Pde2a / 207728
• MGIID: 2446107
• Length: 953
• Species: Mus musculus
• Alignment Length: 995
• Identity: 212/995 - (21%)
• Similarity: 361/995 - (36%)
• Gaps: 297/995 - (29%)

  Fly   211 NNLSFDGS--TDPKGERNHAEEEPLTPGHDHEDSVVLRR----KVNCLERKAHSLYERRLPRVPK 269
            |...|.|:  ..|.|||.......|..|...::..:|..    .:..|.:.|.......||:|..
Mouse    32 NKFRFPGNIYLRPCGERVRWPPCVLPAGWPGQEDALLSLGAVIDIAGLRQAARDALSAVLPKVET 96

  Fly   270 LH-LLVAGK-----KNPPTEEEEFRTFQRNLMDLKY-------PT----------VLPPNPPLKA 311
            :: .|:.|:     ::||.|..:....:..::..|.       |:          |.|..|.::.
Mouse    97 VYTYLLDGESRLVCEDPPHELPQEGKIREAVISQKRLSCNGLGPSDLLGKPLARLVAPLAPDMQV 161

  Fly   312 L---LVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIII--------- 364
            |   |:..::.|:...|...|.:      |..|:|::|..::|        |.::.
Mouse   162 LVIPLLDKETGSVAAVILVHCGQ------LSDSEEQSLQVVEK--------HALVALRRVQALQQ 212

  Fly   365 ---DARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAETTNLA 426
               :|..:.::||....:.                :|.:.:.|..::.|       | .|..:|.
Mouse   213 RRPEAVQNTSVDASEDQKD----------------EKGYTDHDRKILQL-------C-GELFDLD 253

  Fly   427 MCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQ--------YANRATERLL 483
            ..|::||.:.:       :....||.:..|      :|:::|.|::.        .....:..|.
Mouse   254 ATSLQLKVLQY-------LQQETQATHCCL------LLVSEDNLQLSCKVIGDKVLGEEVSFPLT 305

  Fly   484 NMRLDEIISK----QLEDIFVSDLSTISEQCKNIK--EFDGILTV----RRKSQEGIPMHVRVVP 538
            ..||.:::..    ||:|:...|:    :|.:|:.  |...:|.|    |...|        ||.
Mouse   306 MGRLGQVVEDKQCIQLKDLTSDDV----QQLQNMLGCELQAMLCVPVISRATDQ--------VVA 358

  Fly   539 VACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKL 603
            :||.          |:..||  ||.....:         |.::.|.....::.:..|......||
Mouse   359 LACA----------FNKLGG--DFFTDEDE---------HVIQHCFHYTGTVLTSTLAFQKEQKL 402

  Fly   604 --------------------TSLPLEAPITKIINLLSQVQENCSA---DEARLIDKVLEFLKREG 645
                                .|:.|:..||:..||.:  .|.||.   |:..|:.||.:    .|
Mouse   403 KCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSN--AEICSVFLLDQNELVAKVFD----GG 461

  Fly   646 LYSPQMKEIR--TDDPIATDL--IGALLTGPSVYSS---RRSSNDSIIRTGSSTRTAAIVPAKMK 703
            :...:..|||  .|..||..:  .|.:|..|..|:.   .|..:||   ||..||.....|.|.:
Mouse   462 VVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDS---TGFRTRNILCFPIKNE 523

  Fly   704 SNPII--MELL-----------DESLSWDFDIF------------KLEE---------------- 727
            :..:|  .||:           ||.|:..|.|:            |:.|
Mouse   524 NQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHM 588

  Fly   728 -ITD--YHPLLYLGME------------------------------MFRRFDVFATLNIDENVCK 759
             ::|  |..||:.|::                              |.:..:......||.....
Mouse   589 KVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLA 653

  Fly   760 AWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRME--EATAL-IAAAAHDVD 821
            .:..:::..|| ...|||..||..|     :....|..|::.:.:.:|  |..|| |:...||:|
Mouse   654 RFCLMVKKGYR-DPPYHNWMHAFSV-----SHFCYLLYKNLELSNYLEDIEIFALFISCMCHDLD 712

  Fly   822 HPGRSSAFLCNSNDALAVLY-NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIID 885
            |.|.:::|...|...||.|| ::.:|:|.||.|....: |.....|||.:..::.|:.....:.|
Mouse   713 HRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAI-LNTHGCNIFDHFSRKDYQRMLDLMRD 776

  Fly   886 MILATEMTRH---FEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCI 947
            :||||::..|   |:.|.|...|......|.|:.        |:..:|:...|:|:..:..:...
Mouse   777 IILATDLAHHLRIFKDLQKMAEVGYDRNNRQHHR--------LLLCLLMTSCDLSDQTKGWKTTR 833

  Fly   948 EWARRIAEEYFMQTDEEK-QRHLPIVMPMFDRATCSIPKSQIGFIEYI-------IQDMMHAWES 1004
            :.|..|.:|:|.|.|.|| ..:.|  |.|.||....||:.||.|:|:|       :||:
Mouse   834 KIAELIYKEFFSQGDLEKAMGNRP--MEMMDREKAYIPELQISFMEHIAMPIYKLLQDL------ 890

  Fly  1005 FIDMPQLITYMQINYSQWKK 1024
            |....:|...:..|...|.|
Mouse   891 FPKAAELYERVASNREHWTK 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	19/97 (20%)
		PAS_9	463..539	CDD:290162	19/93 (20%)
		PDEase_I	775..1016	CDD:278654	74/255 (29%)
Pde2a	XP_006507586.1	GAF	253..400	CDD:214500	35/192 (18%)
		GAF	422..571	CDD:214500	42/157 (27%)
		PDEase_I	668..901	CDD:365964	74/254 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920