Protein Alignment Pde8 and pde-6

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_001370828.1
• Gene: pde-6 / 190808
• WormBaseID: WBGene00022389
• Length: 760
• Species: Caenorhabditis elegans
• Alignment Length: 807
• Identity: 229/807 - (28%)
• Similarity: 343/807 - (42%)
• Gaps: 210/807 - (26%)

  Fly   304 PPNPPLKALLVFHKSDSICEAITAACQRHQ----LDVTLVKS---------KEEALDTLQKS--- 352
            ||.|.|..            |.|::...|.    :.|.::|:         :...||:|:.|
 Worm    79 PPTPLLTV------------AATSSSTAHDTFGPMQVKMLKTAVIVTEGTGESVLLDSLRASGWI 131

  Fly   353 -------YATAQ----CYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDV 406
                   .||:.    |...:.||.|..   ....||:.:.......: .|:::.:|...||.
 Worm   132 CTVSFPTQATSDVESICPLAVFIDLRVP---HPSQIAKDVSSVSTEEV-LIVSIAEKHISEKR-- 190

  Fly   407 LIALLDAGVNRCVAETTNLAMCSVELKQILHSII-------------RPHNVMSTQQALYTALHR 458
                     .|.:|::           .|:|.:.             |..|.:....||:..|..
 Worm   191 ---------RRALAQS-----------NIIHHVTWNTRDVVLFDYVGRLANRIRALPALFAVLDE 235

  Fly   459 LKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVR 523
            ..:.|.|.|:...:||.|||.|.:......|:|.:...:                        :|
 Worm   236 TDQAVEICDEQRVVQYVNRAYENVTGCIRSEVIGQPESE------------------------MR 276

  Fly   524 RKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSF--- 585
            |||                                       ||:    .||.....|.|.:
 Worm   277 RKS---------------------------------------LPR----ARGEEERRRSCDWKFI 298

  Fly   586 --------------------DVRSIASDGLRRTSLAKLTSLP--LEAPITKIINLLSQVQENCSA 628
                                |..:|    .|..||..|.|..  :||||::::.:|..|......
 Worm   299 RVPFANNSQFVYMKRSNTTGDTAAI----FRDVSLKSLKSQTGGIEAPISEVLTMLRDVSARVDG 359

  Fly   629 DEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGAL--LTGP------SVYSSRRSSNDSI 685
            :.|:.|...::.|....||:|.:...|..|.|||.....|  |..|      ||..:.|....|
 Worm   360 EPAQTIKDAMKVLSSHELYAPSINRFRDADRIATQYYDGLIRLHHPARQRKRSVVDAHREKRGS- 423

  Fly   686 IRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFAT 750
              .|...|.:|.|          ...|:....|.|||..||:::|:|.|..:||::|.|:.|...
 Worm   424 --HGERRRVSADV----------KNALENDNCWKFDILHLEKVSDHHALSQVGMKVFERWKVCDV 476

  Fly   751 LNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLV-MDRMEEATALIA 814
            |...:::...|:..|||||...|||||:||||||:|||..|   |.:..:.| ::......||:|
 Worm   477 LGCSDDLLHRWILSIEAHYHAGNTYHNATHAADVLQATSFF---LDSPSVAVHVNESHAVAALLA 538

  Fly   815 AAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDD-KINIFKNLDKETYKS 878
            ||.||:|||||.:|:|.|:..:||:||||.::|||||.|:.|:|||..: .:|||.:|.:|.:..
 Worm   539 AAVHDLDHPGRGNAYLINTRQSLAILYNDNSILENHHIALAFQLTLQHNANVNIFSSLSREEFIQ 603

  Fly   879 ARSTIIDMILATEMTRHFEHLAKFVSVF---GGEEPRDHNPQTDEETSILMRRMLIKVADVSNPA 940
            .|..:::|:|||:::||||:||||..:.   ..||.||.|       |:.:..||:|.||:||||
 Worm   604 MRHAMVEMVLATDISRHFEYLAKFNKMHVTDVPEEQRDTN-------SLTICDMLVKCADISNPA 661

  Fly   941 RPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESF 1005
            |....|..||.||.||||.||.|||::.||:.|.:|||.||::|.:|.|||:...::....:..|
 Worm   662 REWGLCQRWAHRIVEEYFEQTREEKEKGLPVTMEVFDRNTCNVPITQCGFIDMFAREAFATFTEF 726

  Fly  1006 IDMPQLITYMQINYSQWKKYDEQGVNT 1032
            ..:.:|...::.||.:||....|...|
 Worm   727 AKLGELSDQLESNYEKWKVMTSQWTPT 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	15/79 (19%)
		PAS_9	463..539	CDD:290162	15/75 (20%)
		PDEase_I	775..1016	CDD:278654	109/245 (44%)
pde-6	NP_001370828.1	PDEase_I	501..737	CDD:395177	109/245 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167985
Domainoid	1	1.000	208	1.000	Domainoid score	I1664
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		oto18928
orthoMCL	1	0.900	-	-		OOG6_105168
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880