DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde6b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_032832.2	Gene:	Pde6b / 18587	MGIID:	97525	Length:	856	Species:	Mus musculus

Alignment Length:	902	Identity:	188/902 - (20%)
Similarity:	339/902 - (37%)	Gaps:	223/902 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 EEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQL-DVTLVKSKEEALD 347
            ||:.|:|            |..||.. |...|.|..| .|.:..||:...| |...::.    |.
Mouse     5 EEQVRSF------------LDGNPTF-AHQYFGKKLS-PENVAGACEDGWLADCGSLRE----LC 51

  Fly   348 TLQKSYATAQCYHLIIIDARSSKNLD--AEHIAR---TIRHTHGHHL-------------TTIIA 394
            .:::|.|..:    ::.|.:.|.|::  ...|.|   ||.|.....|             |.:.:
Mouse    52 QVEESAALFE----LVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQRNGIAELATRLFS 112

  Fly   395 VCKKSFFE-----KDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPH----------- 443
            |...|..|     .|..::..||.|:...||:|..:    :.::.:...   ||
Mouse   113 VQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKM----INVQDVAEC---PHFSSFADELTDY 170

  Fly   444 ---NVMSTQ-------QALYTALHRLKEVVLITDDL-LRIQYANRATERLLNMRL---------- 487
               |::||.       .|:..|:::|......::|. :..:|.|.||   ||:::
Mouse   171 VTKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFAT---LNLKIYHLSYLHNCE 232

  Fly   488 ---DEIISKQLEDIFVSDLSTISEQ-------------CKNI----------KEF---------- 516
               .:::......:| .:|:.|..|             |:..          |||
Mouse   233 TRRGQVLLWSANKVF-EELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWPVLMGE 296

  Fly   517 ----------DGILTVRRKSQEGIPMH----VRVVPV------ACIGSAPTHLIFNFDVPGGQMD 561
                      ||...|..|..:.| :|    ::|:|.      |.....||::
Mouse   297 AQPYSGPRTPDGREIVFYKVIDYI-LHGKEDIKVIPTPPADHWALASGLPTYV------------ 348

  Fly   562 FIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTS---LAKLTSLPLEAPITKIINLLSQVQ 623
                      |..|.:.::...|.|......:|....|   :..:.|:|:.....:|:.:.:...
Mouse   349 ----------AESGFICNIMNASADEMFNFQEGPLDDSGWVIKNVLSMPIVNKKEEIVGVATFYN 403

  Fly   624 EN-----CSADEARLIDKVLEFLKREGLYS---PQMKEIRTDDPIATDLIGALLTGPSVYSSRRS 680
            ..     ...||. |::.:.:||....|.:   .:|.::.....||.|::        :|.. |.
Mouse   404 RKDGKPFDDQDEV-LMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMV--------LYHV-RC 458

  Fly   681 SNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESL--SWDFDIFKLE----EITDYHPLLYLGM 739
            ..|.|.....:.......||..:.:. :.::|.|.|  ...|||::..    |.|:.. |:..|:
Mouse   459 DKDEIQEILPTRDRLGKEPADCEEDE-LGKILKEELPGPTKFDIYEFHFSDLECTELE-LVKCGI 521

  Fly   740 EMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMD 804
            :|:....|.....|.:.|...:|..:...||:. ||||..|..:|.|.  .|...:|.|......
Mouse   522 QMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRI-TYHNWRHGFNVAQT--MFTLLMTGKLKSYYT 583

  Fly   805 RMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITF-KLTLGDDKINIF 868
            .:|....:.|...||:||.|.::.:...|.:.||.|:.. ::||.||  :.| |..|.::.:||:
Mouse   584 DLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS-SILERHH--LEFGKFLLAEESLNIY 645

  Fly   869 KNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSI------LMR 927
            :||::..::.....:...|:||::..:|:....|..:....:..:......|..|:      ::.
Mouse   646 QNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVM 710

  Fly   928 RMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQ--RHLPIVMPMFDR-ATCSIPKSQIG 989
            .|::...|:|...:|.:...:.|..:|.|::.|.|.|:.  ...||  ||.|| ....:||.|:|
Mouse   711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPI--PMMDRNKAAELPKLQVG 773

  Fly   990 FIEYIIQDMMHAWESFID--MPQLITYMQINYSQWK----KYDEQGVNTLAEIMAKQ 1040
            ||:::...:...:..|.:  :| :...:|.|..:||    :| |..|..|.|...|:
Mouse   774 FIDFVCTFVYKEFSRFHEEILP-MFDRLQNNRKEWKALADEY-EAKVKALEEEKKKE 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	23/140 (16%)
		PAS_9	463..539	CDD:290162	22/136 (16%)
		PDEase_I	775..1016	CDD:278654	62/252 (25%)
Pde6b	NP_032832.2	GAF	71..230	CDD:214500	33/168 (20%)
		GAF	252..439	CDD:214500	32/210 (15%)
		PDEase_I	556..801	CDD:278654	62/252 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850