Protein Alignment Pde8 and Pde9a

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_036016291.1
• Gene: Pde9a / 18585
• MGIID: 1277179
• Length: 536
• Species: Mus musculus
• Alignment Length: 533
• Identity: 138/533 - (25%)
• Similarity: 230/533 - (43%)
• Gaps: 139/533 - (26%)

  Fly   586 DVRSIASDGLRRTSLAKLT----------SLPLEAPITK-----------------IINLLSQVQ 623
            |:..||:...|.|:::.||          ::|..:..|.                 |..:|:||.
Mouse    37 DLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELIQGVLAQVA 101

  Fly   624 ENCS------------ADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYS 676
            |..|            |:...:::|.:|.   |||...::::.::|.....:.:.|
Mouse   102 EQFSRAFKINELKAEVANHLAVLEKRVEL---EGLKVVEIEKCKSDIKKMREELAA--------- 154

  Fly   677 SRRSSNDSIIRTGSSTRTAAI----------VPA--KMKSNPIIMELLDESLSWDFDIFKLE--E 727
              |:|     ||....:.:.:          ||.  |...:|..:|.|.:.   .||::..|  |
Mouse   155 --RNS-----RTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKP---TFDVWLWEPNE 209

  Fly   728 ITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFI 792
            :......:|..:.:.|.|      :|:....:.||..:..:|| :|.:||..|...|.|...:.:
Mouse   210 MLSCLEHMYHDLGLVRDF------SINPITLRRWLLCVHDNYR-NNPFHNFRHCFCVTQMMYSMV 267

  Fly   793 ------TQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHH 851
                  .:.:..|:||:        :.||..||:||||.::.:..|:...|||.|||::.|||||
Mouse   268 WLCGLQEKFSQMDILVL--------MTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHH 324

  Fly   852 AAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNP 916
            .||.|:: |...:.|||.::..|.::..|..:|.:||||:|.||.|.:..|      :|..::..
Mouse   325 CAIAFQI-LARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSF------KEKMENFD 382

  Fly   917 QTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATC 981
            .::||...|::.:|||..|:||..|||:....|...:.||||||:|.||...|| |.|..||...
Mouse   383 YSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLP-VAPFMDRDKV 446

  Fly   982 SIPKSQIGFIEYIIQDMMHA----------------WESFIDMPQLITYMQINYSQWKKYDE--- 1027
            :...:|||||::::..|...                |||           :.:|.:.|:.|:
Mouse   447 TKATAQIGFIKFVLIPMFETVTKLFPVVEETMLRPLWES-----------REHYEELKQLDDAMK 500

  Fly  1028 -----QGVNTLAE 1035
                 |.|..:||
Mouse   501 EVKAVQRVQAVAE 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	85/262 (32%)
Pde9a	XP_036016291.1	PDEase_I	250..478	CDD:395177	82/243 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950