DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde8a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_032829.1	Gene:	Pde8a / 18584	MGIID:	1277116	Length:	823	Species:	Mus musculus

Alignment Length:	770	Identity:	297/770 - (38%)
Similarity:	441/770 - (57%)	Gaps:	59/770 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 LKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLD 373
            |:.||||.|.||.|.....||::.....|:.|..:..|...|.     :.:.:||||.|..:.:|
Mouse    76 LQVLLVFTKEDSQCNGFHRACEKAGFKCTVTKEVQTVLTCFQD-----KLHDIIIIDHRYPRQMD 135

  Fly   374 AEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHS 438
            ||.:.|:||.:.....|.|:.|.:: ..:::..|:..|.||..|...|..|:..|..||.|:...
Mouse   136 AETLCRSIRSSKFSENTVIVGVVRR-VDKEESSLMPFLAAGFTRRFIENPNVMACYNELLQLACG 199

  Fly   439 IIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVS-- 501
            .:|....:....:::|||.:.:|.:.||.:...|||||.|.|..:..:..|:|.|:|..:.::
Mouse   200 EVRSQLKLRACNSVFTALEKSQEAIEITSEDHIIQYANPAFESTMGYQSGELIGKELAQVPINEK 264

  Fly   502 --DLSTISEQCKNI-KEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQ---- 559
              ||......|..: ||:.|:...::|:.:.|..:|:::||...|....|.:....|..|.
Mouse   265 KGDLLDAINSCVTVDKEWQGVYHTQKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKVE 329

  Fly   560 --MDFIATLPQPKEAPRGSLHSVRRCSFDVRSIA------SDGLRRTSLAKLTSLPLEAPITKII 616
              .:.:.|..| .:...|.....|:.|.|.::::      |...|.:|||::.|:.:||||||:|
Mouse   330 TTTECVQTDSQ-TDNQAGKHKDRRKHSMDAKAVSSRTSDVSSQRRHSSLARIHSMMIEAPITKVI 393

  Fly   617 NLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRR-S 680
            |:::..|||........:::||:.|:...|||||..  ..|||.||||:|.|::.    ..|| |
Mouse   394 NIINAAQENSPVPVTEALNRVLDILRTTELYSPQFN--AQDDPHATDLVGGLMSD----GLRRFS 452

  Fly   681 SNDSIIRTGS----STRTAAIVPAKMKSNPIIMEL-LDESLSWDFDIFKLEEITDYHPLLYLGME 740
            .|:.|:.|.:    |...|  .|..:...|..:.| ::....||||||:||..|...||:|||::
Mouse   453 GNEYILATKNLPPLSNNLA--TPVSLHDVPPRIALAIENEEQWDFDIFELEVATQNRPLIYLGLK 515

  Fly   741 MFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDR 805
            .|.||.:...|...|...::|..:||::|..||.||||||||||:.||..|:::...|:.|  ||
Mouse   516 TFARFGMCEFLQCSETTLRSWFQMIESNYHSSNPYHNSTHAADVLHATAYFLSRDKIKETL--DR 578

  Fly   806 MEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKN 870
            ::|..|||||..||||||||:::||||:.:.|||||||..|||:||.|:.|:|||.:|:.||||.
Mouse   579 IDEVAALIAATVHDVDHPGRTNSFLCNAGNQLAVLYNDTAVLESHHVALAFQLTLENDQCNIFKQ 643

  Fly   871 LDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFG-------GEEPRDHNPQ------TDEET 922
            :::..|::.|.:||||:||||||:||||:.||::...       .||| |.:.:      ...|:
Mouse   644 MERNDYRTLRQSIIDMVLATEMTKHFEHVNKFINSINKPLTAQESEEP-DRSLEDIKAMLKTPES 707

  Fly   923 SILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQ 987
            ..|::||:||.||||||.||::.|||||.||:||||.|||||||..||:|||:|||.||||||||
Mouse   708 RALIKRMMIKCADVSNPCRPLEHCIEWAARISEEYFSQTDEEKQLDLPVVMPVFDRNTCSIPKSQ 772

  Fly   988 IGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQPP 1042
            |.||:|.|.||..||::|:|:|.|:.::..|:..||..||:.:.:|     :.||
Mouse   773 ISFIDYFITDMFDAWDAFVDLPNLMQHLDDNFRYWKGLDEKKLRSL-----RPPP 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	23/84 (27%)
		PAS_9	463..539	CDD:290162	22/80 (28%)
		PDEase_I	775..1016	CDD:278654	140/253 (55%)
Pde8a	NP_032829.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		OmpR	78..>155	CDD:223816	26/81 (32%)
		REC	79..>165	CDD:302758	28/91 (31%)
		PAS_9	222..320	CDD:290162	27/97 (28%)
		PAS	226..320	CDD:238075	26/93 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..373		6/35 (17%)
		PDEase_I	550..801	CDD:278654	140/253 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844391
Domainoid	1	1.000	286	1.000	Domainoid score	I1596
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1182
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50014
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		otm42380
orthoMCL	1	0.900	-	-		OOG6_105168
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	1	1.000	-	-		X2464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940