DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and Pde7a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001116231.1	Gene:	Pde7a / 18583	MGIID:	1202402	Length:	482	Species:	Mus musculus

Alignment Length:	369	Identity:	111/369 - (30%)
Similarity:	183/369 - (49%)	Gaps:	63/369 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 MELLDESL------------SWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAW 761
            :::|||..            :|:||||..:.:|:.:.|:.|...:|....:....::|....:.:
Mouse   133 LDILDEDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRF 197

  Fly   762 LAVIEAHYRKSNTYHNSTHAADVMQATGAFI------TQLTNKDMLVMDRMEEATALIAAAAHDV 820
            |.:|:..|...|.|||:.|||||.||...::      :.:|..|:|:        :|||||.||:
Mouse   198 LVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASSVTPWDILL--------SLIAAATHDL 254

  Fly   821 DHPGRSSAFLCNSNDALAVLYNDLTVLENHH--AAITFKLTLGDDKINIFKNLDKETYKSARSTI 883
            ||||.:..||..:|..||.||.:.:||||||  :|:......|     :|.:|..|:.:...:.|
Mouse   255 DHPGVNQPFLIKTNHYLATLYKNSSVLENHHWRSAVGLLRESG-----LFSHLPLESRQEMEAQI 314

  Fly   884 IDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQ-----TDEETSILMRRMLIKVADVSNPARPM 943
            ..:||||:::|..|:|:.|         |.|..:     .|.....|:.:|.:|.||:.||.|..
Mouse   315 GALILATDISRQNEYLSLF---------RSHLDKGDLHLDDGRHRHLVLQMALKCADICNPCRNW 370

  Fly   944 QFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFID- 1007
            :...:|:.::.||:|.|.|.||:.||. |.|:.||.|.||...||||:.|:::.:...|..|.|
Mouse   371 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSDT 434

  Fly  1008 --MPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQPPVGKMANS 1049
              ...::.::.:|.:.||.            :.:|.|..:.||:
Mouse   435 RLSQTMLGHVGLNKASWKG------------LQRQQPSSEDANA 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	87/256 (34%)
Pde7a	NP_001116231.1	Endonuc-BglII	<51..128	CDD:286304
Pde7a	NP_001116231.1	PDEase_I	211..431	CDD:278654	85/242 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850