DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde4a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_899668.1	Gene:	Pde4a / 18577	MGIID:	99558	Length:	844	Species:	Mus musculus

Alignment Length:	541	Identity:	149/541 - (27%)
Similarity:	245/541 - (45%)	Gaps:	91/541 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 EDIFVSDLSTISEQCKNIKEFDGILT-----VRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDV 555
            ||:.|:..:.:....:|::....:||     ..::|..|.|      |..|
Mouse   169 EDLIVTPFAQVLASLRNVRSNFSLLTNVPIPSNKRSPLGGP------PSVC-------------- 213

  Fly   556 PGGQMDFIATLPQP--KEAPRGSLHSVRRC---------SFDVRSIASDGLRRTSLAKLTSLPLE 609
                   .|||.:.  ::..|.:|..:..|         ...|..:||...:|....:||.|
Mouse   214 -------KATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHL--- 268

  Fly   610 APITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSV 674
            :.:::..|.:|:...|...|:...::......::.....|....::...|::.      :||..
Mouse   269 SEMSRSGNQVSEYISNTFLDKQHEVEIPSPTPRQRPFQQPPPAAVQQAQPMSQ------ITGLK- 326

  Fly   675 YSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGM 739
                     .::.|||..........|.....::.:.|:....|..:||.:.|......|..:..
Mouse   327 ---------KLVHTGSLNINVPRFGVKTDQEDLLAQELENLSKWGLNIFCVSEYAGGRSLSCIMY 382

  Fly   740 EMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMD 804
            .:|:..|:....:|..:....::..:|.||.....||||.|||||:|:|...:.  |.....|..
Mouse   383 TIFQERDLLKKFHIPVDTMMTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLA--TPALDAVFT 445

  Fly   805 RMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFK 869
            .:|...||.|||.|||||||.|:.||.|:|..||::|||.:||||||.|:.||| |.::..:||:
Mouse   446 DLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKL-LQEENCDIFQ 509

  Fly   870 NLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETS----------- 923
            ||.|...:|.|..:|||:|||:|::|...||...::.          :|.:.||
Mouse   510 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV----------ETKKVTSSGVLLLDNYSD 564

  Fly   924 -ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQ 987
             |.:.|.::..||:|||.:|::...:|..||..|:|.|.|.|::|.:.| .||.|:.|.|:.|||
Mouse   565 RIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEI-SPMCDKHTASVEKSQ 628

  Fly   988 IGFIEYIIQDMMHAWESFIDM 1008
            :|||:||:..:   ||::.|:
Mouse   629 VGFIDYIVHPL---WETWADL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	9/47 (19%)
		PAS_9	463..539	CDD:290162	9/47 (19%)
		PDEase_I	775..1016	CDD:278654	101/246 (41%)
Pde4a	NP_899668.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		PDEase_I	418..659	CDD:278654	101/246 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850