Protein Alignment Pde8 and Pde3b

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: NP_035185.2
• Gene: Pde3b / 18576
• MGIID: 1333863
• Length: 1099
• Species: Mus musculus
• Alignment Length: 587
• Identity: 141/587 - (24%)
• Similarity: 233/587 - (39%)
• Gaps: 110/587 - (18%)

  Fly   499 FVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFD--VPGGQMD 561
            |.|:|.||.:|              |.|...:..|   ..:...|:.|:|.:.|..  ||
Mouse   460 FSSNLFTIPKQ--------------RSSSVSLTHH---AGLRRAGALPSHSLLNSSSHVP----- 502

  Fly   562 FIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENC 626
                      ...|||.:.....|   ...:|.|.:.::....||...:........|.....|.
Mouse   503 ----------VSAGSLTNRSPIGF---PDTTDFLTKPNIILHRSLGSVSSAADFHQYLRNSDSNL 554

  Fly   627 SADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSS 691
            .:.....|.|.:...:.:|...|..|....|..:.:.....::......:.:::..:..:...|.
Mouse   555 CSSCGHQILKYVSTCEPDGTDHPSEKSGEEDSSVFSKEPLNIVETQEEETMKKACRELFLEGDSH 619

  Fly   692 TRTAAIVP---AKMKSNPIIME----LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFD--- 746
            ....|..|   .::..:|:::|    |:::..:|:|.||:|.|.........|...|:..|.
Mouse   620 LMEEAQQPNIDQEVSLDPMLVEDYDSLIEKMNNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTG 684

  Fly   747 VFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ----------------- 794
            :..|..|.......:...:|..|| ...|||..||.||:.|.....|:
Mouse   685 LLETFKIPTQEFMNYFRALENGYR-DIPYHNRVHATDVLHAVWYLTTRPIPGLPQIHNNHETETK 748

  Fly   795 --------------LTNKDMLVMD-----------RMEEATALIAAAAHDVDHPGRSSAFLCNSN 834
                          :::|...:.|           .:|.....:|||.||.|||||::|||..:|
Mouse   749 ADSDGRLGSGQIAYISSKSCCIPDMSYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATN 813

  Fly   835 DALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHL 899
            ...||||||.:||||||||..:.|.|...:.|...|||...:|..|..:|:.||||::.:||:.|
Mouse   814 APQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFDFL 878

  Fly   900 AKFVSVFGGEEPRDHNPQ----TDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQ 960
            |:|     ..:..|.|..    :.|...:|:.::.||:||::.||:.....:.|...|..|::.|
Mouse   879 AEF-----NAKANDVNSNGIEWSSENDRLLVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQ 938

  Fly   961 TDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKY 1025
            .|||....||| .|..||::..:.|.|..||.:|:..:.:::::...:|          .||.:.
Mouse   939 GDEEATLGLPI-SPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLP----------GQWIET 992

  Fly  1026 DE 1027
            :|
Mouse   993 EE 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	9/39 (23%)
		PAS_9	463..539	CDD:290162	9/39 (23%)
		PDEase_I	775..1016	CDD:278654	87/286 (30%)
Pde3b	NP_035185.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Interaction with RAPGEF3. /evidence=ECO:0000250	1..28
		DUF1109	60..241	CDD:284050
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..423
		Interaction with PIK3R6. /evidence=ECO:0000250	415..439
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..590		4/19 (21%)
		PDEase_I	712..986	CDD:278654	86/279 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844410
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850