DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde1c

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_006505793.1	Gene:	Pde1c / 18575	MGIID:	108413	Length:	861	Species:	Mus musculus

Alignment Length:	507	Identity:	130/507 - (25%)
Similarity:	230/507 - (45%)	Gaps:	89/507 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 RRKSQ--------EGIPMHVRVVPVACI--GSAPTHLIFNFDVPGGQMDFIATLPQPKEAPRGSL 577
            |.|||        :|:..:::..|...|  .:.|...|...::|  |:|              |.
Mouse   141 RSKSQNCLWNSLIDGLTGNIKEKPRPTIVQDTRPPEEILADELP--QLD--------------SP 189

  Fly   578 HSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLK 642
            .::.:.||.:||:...              ||.....:::|...::...:..|:..||:....|.
Mouse   190 EALVKTSFRLRSLVKQ--------------LERGEASVVDLKKNLEYAATVLESVYIDETRRLLD 240

  Fly   643 REGLYSPQMKEIRTD--DPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKM--- 702
            .|    .::.:|::|  .....|.:.:..|.......|||......::......|.|...:|
Mouse   241 TE----DELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRR 301

  Fly   703 KSN-------PIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKA 760
            .||       |.:::.|.:..:|.||:|.|.|.:..|.|.::..|:..|:|:.:...|..:...:
Mouse   302 TSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS 366

  Fly   761 WLAVIEAHYRK-SNTYHNSTHAADVMQA-------TGA--FITQLTNKDMLVMDRMEEATALI-A 814
            ::..:|..|.| .|.|||..|||||.|.       ||.  ::|:|            |..|:| :
Mouse   367 FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTEL------------EIFAIIFS 419

  Fly   815 AAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSA 879
            ||.||.:|.|.::.|...:....|:||||.:||||||.:..::|...|:::||..||.|:.::..
Mouse   420 AAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREF 484

  Fly   880 RSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQ 944
            |:.:|:|::||:|:.||:.:....:..       ..|:..|:...|  .:::..||:|:||:...
Mouse   485 RTLVIEMVMATDMSCHFQQIKAMKTAL-------QQPEAIEKPKAL--SLMLHTADISHPAKAWD 540

  Fly   945 FCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQ 996
            ....|...:.||:|.|.|.|.:..||. .|:.||.:..:.:||:|||::|::
Mouse   541 LHHRWTMSLLEEFFRQGDREAELGLPF-SPLCDRKSTMVAQSQVGFIDFIVE 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	5/23 (22%)
		PAS_9	463..539	CDD:290162	5/23 (22%)
		PDEase_I	775..1016	CDD:278654	75/232 (32%)
Pde1c	XP_006505793.1	PDEase_I_N	241..297	CDD:369905	10/59 (17%)
		PDEase_I	382..610	CDD:365964	75/232 (32%)
		PTZ00121	<698..>788	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850