DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pde8 and Pde1b

DIOPT Version :9

Sequence 1:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster
Sequence 2:NP_032826.1 Gene:Pde1b / 18574 MGIID:97523 Length:535 Species:Mus musculus


Alignment Length:500 Identity:128/500 - (25%)
Similarity:216/500 - (43%) Gaps:70/500 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   595 LRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTD-- 657
            ::..||.:.....||.....|..|...::...|..||..||:..:.|..|    .:::|:|:|  
Mouse    32 IKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTE----DELRELRSDAV 92

  Fly   658 DPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKM------KSNPIIMELLDESL 716
            .....|.:.:..|..:....||:......|:......|.|...:|      ...|.....:...|
Mouse    93 PSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVHNCL 157

  Fly   717 S----WDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYH 776
            .    |.||:|.|....|.|.|..:..|:..|..:.:...|......::|..:|..|.| .|.||
Mouse   158 KNLDLWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYH 222

  Fly   777 NSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLY 841
            |..|||||.|....|:  |....:..:..:|....:.|||.||.:|.|.:::|...:....|:||
Mouse   223 NQIHAADVTQTVHCFL--LRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILY 285

  Fly   842 NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVF 906
            ||.:||||||.:..|:: :.||::|||.||.|:.:...|:.:|:|:|||:|:.||:.:....:..
Mouse   286 NDRSVLENHHISSVFRM-MQDDEMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTAL 349

  Fly   907 GGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPI 971
            ...|      :.|:..::   .:|:..||:|:|.:.......|.:.:.||:|.|.|:|.:..||.
Mouse   350 QQLE------RIDKSKAL---SLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPF 405

  Fly   972 VMPMFDRATCSIPKSQIGFIEYIIQDMMHA--------------------------W-ESFIDM- 1008
             .|:.||.:..:.:||||||::|::.....                          | :..:|: 
Mouse   406 -SPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADDDSKPKSQPSFQWRQPSLDVD 469

  Fly  1009 -----PQLIT-------YMQINYSQWKKYDEQGVNTLAEIMAKQP 1041
                 |.:::       |:|.|..:||:....|:.....|....|
Mouse   470 VGDPNPDVVSFRATWTKYIQENKQKWKERAASGITNQMSIDELSP 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde8NP_001163275.2 PAS 459..539 CDD:238075
PAS_9 463..539 CDD:290162
PDEase_I 775..1016 CDD:278654 79/280 (28%)
Pde1bNP_032826.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Calmodulin-binding. /evidence=ECO:0000255 27..47 3/14 (21%)
PDEase_I_N 80..136 CDD:285672 11/59 (19%)
PDEase_I 221..448 CDD:278654 75/239 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..474 2/29 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 495..535 4/19 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167844389
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.850

Return to query results.
Submit another query.