DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and Pde1a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001153054.1	Gene:	Pde1a / 18573	MGIID:	1201792	Length:	545	Species:	Mus musculus

Alignment Length:	416	Identity:	118/416 - (28%)
Similarity:	199/416 - (47%)	Gaps:	58/416 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   608 LEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTD-------DPIA---T 662
            ||.....:::|...::...|..||..||:....|..|    .::.:|:||       |.:|   |
Mouse    42 LEKGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTE----DELSDIQTDSVPSEVRDWLASTFT 102

  Fly   663 DLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSN---------PIIMELLDESLSW 718
            ..:|.:...|......|    ||:.   :.:....|....:.|         ..::..|.|...|
Mouse   103 RKMGMMKKKPEEKPKFR----SIVH---AVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKW 160

  Fly   719 DFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAA 782
            .||:|.|.|.:..|.|.::..|:|.|:|:.....|..:...|:...:|..|.| .|.|||..|||
Mouse   161 SFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAA 225

  Fly   783 DVMQA-------TGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVL 840
            ||.|.       || .:..||..::|.|        :.|||.||.:|.|.::.|...:...:|:|
Mouse   226 DVTQTVHYIMLHTG-IMHWLTELEILAM--------VFAAAIHDYEHTGTTNNFHIQTRSDVAIL 281

  Fly   841 YNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSV 905
            |||.:||||||.:..::| :.::::||..||.|:.::..|:.:|:|:|||:|:.||:.:...
Mouse   282 YNDRSVLENHHVSAAYRL-MQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNI--- 342

  Fly   906 FGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLP 970
                  |:...|.:.........:::..||:|:||:..:....|...:.||:|:|.|:|.:..||
Mouse   343 ------RNSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLP 401

  Fly   971 IVMPMFDRATCSIPKSQIGFIEYIIQ 996
            . .|:.||.:..:.:||||||::|::
Mouse   402 F-SPLCDRKSTMVAQSQIGFIDFIVE 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	75/229 (33%)
Pde1a	NP_001153054.1	Calmodulin-binding	24..44		1/1 (100%)
		PDEase_I_N	77..133	CDD:369905	13/66 (20%)
		PDEase_I	218..434	CDD:365964	75/229 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920