DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde8 and Pde1a

DIOPT Version :10

Sequence 1:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster
Sequence 2:NP_058024.2 Gene:Pde1a / 18573 MGIID:1201792 Length:545 Species:Mus musculus


Alignment Length:416 Identity:118/416 - (28%)
Similarity:199/416 - (47%) Gaps:58/416 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   608 LEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTD-------DPIA---T 662
            ||.....:::|...::...|..||..||:....|..|    .::.:|:||       |.:|   |
Mouse    42 LEKGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTE----DELSDIQTDSVPSEVRDWLASTFT 102

  Fly   663 DLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSN---------PIIMELLDESLSW 718
            ..:|.:...|......|    ||:.   :.:....|....:.|         ..::..|.|...|
Mouse   103 RKMGMMKKKPEEKPKFR----SIVH---AVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKW 160

  Fly   719 DFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRK-SNTYHNSTHAA 782
            .||:|.|.|.:..|.|.::..|:|.|:|:.....|..:...|:...:|..|.| .|.|||..|||
Mouse   161 SFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAA 225

  Fly   783 DVMQA-------TGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVL 840
            ||.|.       || .:..||..::|.|        :.|||.||.:|.|.::.|...:...:|:|
Mouse   226 DVTQTVHYIMLHTG-IMHWLTELEILAM--------VFAAAIHDYEHTGTTNNFHIQTRSDVAIL 281

  Fly   841 YNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSV 905
            |||.:||||||.:..::| :.::::||..||.|:.::..|:.:|:|:|||:|:.||:.:...   
Mouse   282 YNDRSVLENHHVSAAYRL-MQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNI--- 342

  Fly   906 FGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLP 970
                  |:...|.:.........:::..||:|:||:..:....|...:.||:|:|.|:|.:..||
Mouse   343 ------RNSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLP 401

  Fly   971 IVMPMFDRATCSIPKSQIGFIEYIIQ 996
            . .|:.||.:..:.:||||||::|::
Mouse   402 F-SPLCDRKSTMVAQSQIGFIDFIVE 426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde8NP_001163275.2 NtrB 446..>539 CDD:443061
PDEase_I 775..1016 CDD:459723 75/229 (33%)
Pde1aNP_058024.2 Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P14100 24..44 1/1 (100%)
PDEase_I_N 73..133 CDD:462497 14/70 (20%)
Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P14100 114..137 4/29 (14%)
PDEase_I 218..439 CDD:459723 75/229 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 526..545
Blue background indicates that the domain is not in the aligned region.

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