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Protein Alignment Pde8 and pde-3

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_001293571.1	Gene:	pde-3 / 183981	WormBaseID:	WBGene00008443	Length:	693	Species:	Caenorhabditis elegans

Alignment Length:	646	Identity:	170/646 - (26%)
Similarity:	255/646 - (39%)	Gaps:	185/646 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   538 PVACIGSA----PTHLIFN---FDVPGGQM---------------DFIATLPQPK----EAPRGS 576
            ||...|||    |||..|.   ...|.|::               |...:.|...    :..|||
Worm    14 PVMVPGSAPPFQPTHQYFQHHYHQTPPGKLRDRSPRLSAEMRKNRDTATSSPASSGVSIQQRRGS 78

  Fly   577 L---HSVRRCSFDV-----RSIASDG-----------LRRTSL---------AKLTSLPL-EA-- 610
            .   ..|......|     |.:.|||           .|||||         ||:|...| ||
Worm    79 TTQNSGVGSIGLPVLGGRGRGVMSDGHMQRTFHEAMRQRRTSLPANSLSLNGAKVTGSSLSEAKG 143

  Fly   611 -------------------------------PITKIIN--LLSQVQENCSADEARLIDKVLEFLK 642
                                           |:..::|  .|..|.||....|:.::
Worm   144 LIADMLMNKELPGNVASCLRAVTMLLEQRPLPLNGLLNDFGLPSVVENPYGGESMVV-------- 200

  Fly   643 REGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSS------------ND-----------S 684
              |...|::..|...  ..|...| |.|.|:..:..|||            |:           |
Worm   201 --GASKPRISNITFS--TVTSATG-LPTVPAEPNKARSSSYWKTEASPSNNNEHETPVDLLRKIS 260

  Fly   685 IIRTGSSTRTAAIVPA---------KMKSNPIIMELLDESLSWDFDIFKLEEITDYHP---LLYL 737
            :.|..|.|....:|..         ::.::|.    |.|:..|.|.||::..   .||   |..|
Worm   261 VSRKESGTHVDTVVTTIDGQRYDTRELDTDPD----LAETAVWSFPIFQMSR---KHPQTILSRL 318

  Fly   738 GMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQ---------ATGAFIT 793
            ...:|::.::|....:.......:...:|..|.:. .|||..|||||:.         ....|:|
Worm   319 TYNIFQQAELFRIFKVSPIKFFNFFHALEKGYWEI-PYHNRIHAADVLHGCYYLSAHPVRSTFLT 382

  Fly   794 QLTNKDML-----------VMDRME--EATALIAAAA-HDVDHPGRSSAFLCNSNDALAVLYNDL 844
            ..|...:|           :|.::.  |..||..||| ||.|||||::|||....|..|:||||.
Worm   383 PKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAMHDYDHPGRTNAFLVQVEDKKAILYNDR 447

  Fly   845 TVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGE 909
            :||||||||.::|| |...:.:..:|||....|..|..:::.||||::.:|||.:..|.     |
Worm   448 SVLENHHAAESWKL-LNKPENHFIENLDPAEMKRFRYLVLEYILATDLKQHFEIIMTFT-----E 506

  Fly   910 EPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMP 974
            ...:.:.|. |...:|:.::|||:||:::|.:|.....:|..||.||::.|.|:|::|.|||. |
Worm   507 RLTEIDVQV-ETDRLLIGKLLIKMADINSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPIT-P 569

  Fly   975 MFDRATCSIPKSQIGFIEYIIQDMMHAWESF--------IDMPQLITYMQINYSQWKKYDE 1027
            ..||....:.|.|..||.:::..:..|....        :|..:||..|:.|:.:||:..|
Worm   570 YMDRGDAQVAKLQDSFIAHVVSPLATAMNECGLLPILPGLDTSELIINMEHNHRKWKEQIE 630

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.