DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and pde-4

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_871945.1	Gene:	pde-4 / 174235	WormBaseID:	WBGene00020114	Length:	674	Species:	Caenorhabditis elegans

Alignment Length:	803	Identity:	184/803 - (22%)
Similarity:	316/803 - (39%)	Gaps:	230/803 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 KLHLLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQ 333
            :|||....:.:.|:.....||         .|..|||.               ..|:|.....|:
Worm    31 ELHLHNFFRTSSPSASSTSRT---------PPAALPPR---------------TSAVTIPGSNHK 71

  Fly   334 LDVTLVK---SKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAV 395
            |..:...   .:|..:.|.....|||            :..|...|:..:        |::.:..
Worm    72 LTSSASSYHPPRELTVSTFSAGSATA------------ADGLGGAHLTPS--------LSSSVHA 116

  Fly   396 CKKSFFEK--DDVLIALLDAGVNRCVAETTN------------LAMCSVELKQILHSII------ 440
            .::||..:  ||:..|.....|:|..:..:|            .|.....|:.:..::|
Worm   117 RRESFLYRASDDLREASSLRPVSRASSIASNEHGHGDDLIVTPFAQLLASLRNVRSNLISITNIQ 181

  Fly   441 -------------RP--HNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEI 490
                         ||  ||:......::.|...|:|:....|.|..|| .:|:...:.:.:..::
Worm   182 NSDDSRHANRSAKRPPLHNIELPDDVVHCAHDTLEELDWCLDQLETIQ-THRSVSEMASSKFRKM 245

  Fly   491 ISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDV 555
            ::|:|     |..:..|:....:.:|  ::|.....:|..|.....||....|.:.:
Worm   246 LNKEL-----SHFAESSKSGTQVSKF--LITTYMDKEEDEPSIEIEVPTEVQGPSTS-------- 295

  Fly   556 PGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINLLS 620
              |.|. ::.|.:.:.|....:..||:    :|:.:.||
Worm   296 --GPMT-LSILKKAQTAAMNKISGVRK----LRAPSHDG-------------------------- 327

  Fly   621 QVQE---NCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSN 682
            .|.|   ||:.:.|
Worm   328 HVPEYGVNCAREIA--------------------------------------------------- 341

  Fly   683 DSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDV 747
                                    :.|:.||:   |..|:||::|::..|.|..:...:.|:.::
Worm   342 ------------------------VHMQRLDD---WGPDVFKIDELSKNHSLTVVTFSLLRQRNL 379

  Fly   748 FATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQ--LTNKDMLVMDRMEEAT 810
            |.|..|.::....:|..:|.||| :|.|||..|||||.|:....:..  ||.    |...:|...
Worm   380 FKTFEIHQSTLVTYLLNLEHHYR-NNHYHNFIHAADVAQSMHVLLMSPVLTE----VFTDLEVLA 439

  Fly   811 ALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKET 875
            |:.|.|.|||||||.::.:|.|||:.||::|||.:|||.||.|:.||| |.|...:...||.::.
Worm   440 AIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKL-LQDSNCDFLANLSRKQ 503

  Fly   876 YKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHN----PQTDEETSILMRRMLIKVADV 936
            ....|..:|||:|||:|::|...||...::...::...:|    .:.:::..:|  :.:|.:||:
Worm   504 RLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVL--QSMIHLADL 566

  Fly   937 SNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHA 1001
            |||.:|::...:|.:||.|||:.|.|:||:..|.| .||.||...:|.|||:|||:||:..:...
Worm   567 SNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEI-SPMCDRGNVTIEKSQVGFIDYIVHPLYET 630

  Fly  1002 WESFI--DMPQLITYMQINYSQW 1022
            |...:  |...::..::.| .:|
Worm   631 WADLVYPDAQNILDQLEEN-REW 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	16/79 (20%)
		PAS_9	463..539	CDD:290162	14/75 (19%)
		PDEase_I	775..1016	CDD:278654	92/248 (37%)
pde-4	NP_871945.1	PDEase_I	406..647	CDD:278654	92/248 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920