DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde8 and Pde5a

DIOPT Version :9

Sequence 1:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster
Sequence 2:XP_006233322.1 Gene:Pde5a / 171115 RGDID:620995 Length:865 Species:Rattus norvegicus


Alignment Length:871 Identity:182/871 - (20%)
Similarity:300/871 - (34%) Gaps:260/871 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 PLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNL 372
            ||:.::| ..|:.....::.:.::.|:.:|..:...:..|         ||..|:.:....|.:|
  Rat    99 PLRPIVV-KDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGD---------QCSRLLELVKDISSHL 153

  Fly   373 DAEHIARTI-RHTHG---HHLTTIIAVCKKSFFEKDDVLIA-LLDAGVNRCVAETTNLAMCSVEL 432
            |...:...| .|.||   ....::..||:.|  .||..|:: |.|......:.|.:|..:.....
  Rat   154 DVTALCHKIFLHIHGLISADRYSLFLVCEDS--SKDKFLVSRLFDVAEGSTLEEASNNCIRLEWN 216

  Fly   433 KQILHSII---RPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQ 494
            |.|:..:.   .|.|:....:                             :...|..:|:|...:
  Rat   217 KGIVGHVAAFGEPLNIKDAYE-----------------------------DPRFNAEVDQITGYK 252

  Fly   495 LEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQ 559
            .:.|....:....|:...:.:     .:.:||..|.....:                      .:
  Rat   253 TQSILCMPIKNHREEVVGVAQ-----AINKKSGNGGTFTEK----------------------DE 290

  Fly   560 MDFIATLPQPKEAPRG-SLHSVRRCSFDVRSIASDGLRRTSLAKLTSL------PLEAPITKI-- 615
            .||.|.|     |..| .||:.:.    ..:...:..|...|..|.||      .||..:.||  
  Rat   291 KDFAAYL-----AFCGIVLHNAQL----YETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAA 346

  Fly   616 -INLLSQVQ--------ENCSADEARL-------IDKVLEFLKREG-------LYSPQMKEIRTD 657
             |....|||        |:|....:|:       :.|..|.|.||.       :|:..:|  .|.
  Rat   347 TIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREHDANKINYMYAQYVK--NTM 409

  Fly   658 DP---------------------IATDLIGALLTGPSVYSSRR---------------------- 679
            :|                     |:|..||:||..|.....:.                      
  Rat   410 EPLNIPDVTKDNRFPWTNENMGHISTHCIGSLLCTPIKNGKKNKVIGVCQLVNKMEEKTGKIKAF 474

  Fly   680 SSNDS------IIRTG----------------------------------SSTR-----TAAIVP 699
            :.||.      :|..|                                  ..||     .||:||
  Rat   475 NQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALAAAVVP 539

  Fly   700 AKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDEN-------V 757
            :..     .:::.|.|.| ||::..||.     .|..:.|        |..||:.:|       :
  Rat   540 SAQ-----TLKITDFSFS-DFELSDLET-----ALCTIRM--------FTDLNLVQNFQMKHEVL 585

  Fly   758 CKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFIT--QLTNKDMLVMDRMEEATALIAAAAHDV 820
            |: |:..::.:|||:..|||..||.:..|...|.:.  ::.||    :..:|....||||.:||:
  Rat   586 CR-WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNK----LTDLETLALLIAALSHDL 645

  Fly   821 DHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFK---LTLGDDKINIFKNLDKETYKSARST 882
            ||.|.:::::..|...||.||...| :|:||    |.   :.|......|...|..|.||:....
  Rat   646 DHRGVNNSYIQRSEHPLAQLYCHST-MEHHH----FDQCLMVLNSPGNQILSGLSIEEYKTTLKI 705

  Fly   883 IIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCI 947
            |...||||::..:.:...:|..:....|....:|...|    |...||:...|:|...:|.....
  Rat   706 IKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKE----LFLAMLMTACDLSAITKPWPIQQ 766

  Fly   948 EWARRIAEEYFMQTD-EEKQRHLPIVMPMFDRATCSIPKSQIGFIEYI----IQDMMHAWESFID 1007
            ..|..:|.|:|.|.| |.|:.::.....|.......||..|:|||:.|    .:.:.|..|   |
  Rat   767 RIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSE---D 828

  Fly  1008 MPQLITYMQINYSQWKKYDEQGVNTL 1033
            ...|:...:.|..:|:...:|...||
  Rat   829 CLPLLDGCRKNRQKWQALADQQEKTL 854

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde8NP_001163275.2 PAS 459..539 CDD:238075 8/79 (10%)
PAS_9 463..539 CDD:290162 8/75 (11%)
PDEase_I 775..1016 CDD:278654 70/250 (28%)
Pde5aXP_006233322.1 GAF 154..311 CDD:214500 35/223 (16%)
GAF 337..503 CDD:214500 31/167 (19%)
PDEase_I 602..837 CDD:278654 70/250 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166347779
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.850

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