DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde7b

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_008756813.1	Gene:	Pde7b / 140929	RGDID:	621016	Length:	498	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	126/464 - (27%)
Similarity:	213/464 - (45%)	Gaps:	82/464 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 LPLEAP-ITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALL 669
            ||.:.| :.:::.|:.:.:....|.:.|.|      |:.|..:.....::|             |
  Rat    39 LPWDLPEMIRMVKLVWKSKSELQATKPRGI------LENEDAFHGFPGDVR-------------L 84

  Fly   670 TGPS-VYSSRRSSNDSI-IRTGSSTRTAAIVPAKMKSNPII--------------------MELL 712
            .|.: |.:.||.|...| .|..::|..:..:.:|.|...::                    :.||
  Rat    85 RGQTGVPAERRGSYPFIDFRLLNNTTHSGEIGSKKKVRRLLSFQRHFHESRLLRGMTPQAPLHLL 149

  Fly   713 DES--------LS----WDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVI 765
            ||.        ||    ||||||..:.:|:.:.|:.|...:|....:.....:|......:|.::
  Rat   150 DEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMV 214

  Fly   766 EAHYRKSNTYHNSTHAADVMQATGAFITQ------LTNKDMLVMDRMEEATALIAAAAHDVDHPG 824
            :..|...|.|||:.|||||.||...::.:      ||..|:::        .|:|||||||||||
  Rat   215 QEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIML--------GLLAAAAHDVDHPG 271

  Fly   825 RSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGD-DKINIFKNLDKETYKSARSTIIDMIL 888
            .:..||..:|..||.||.:::||||||    ::.|:|. .:..:..:|.||..:.....:..:||
  Rat   272 VNQPFLIKTNHHLANLYQNMSVLENHH----WRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLIL 332

  Fly   889 ATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRI 953
            ||::.|..|.|.:..:....::.|..|.|...    .|.::.:|.||:.||.|..:...:|:.|:
  Rat   333 ATDINRQNEFLTRLKAHLHNKDLRLENIQDRH----FMLQIALKCADICNPCRIWEMSKQWSERV 393

  Fly   954 AEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFID----MPQLITY 1014
            .||::.|.|.|::..|.| .|:.::...|||..||||:.||::.:...|..|..    ...::.:
  Rat   394 CEEFYRQGDLEQKFELEI-SPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSESMLNH 457

  Fly  1015 MQINYSQWK 1023
            :..|.:|||
  Rat   458 LAHNKAQWK 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	81/251 (32%)
Pde7b	XP_008756813.1	PDEase_I	224..458	CDD:278654	81/250 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850