DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde11a

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	NP_543169.1	Gene:	Pde11a / 140928	RGDID:	621793	Length:	935	Species:	Rattus norvegicus

Alignment Length:	988	Identity:	202/988 - (20%)
Similarity:	339/988 - (34%)	Gaps:	271/988 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 NTRPLSVSFGGGGGRSA---LQPEIVEAIRSLDVPALRLNNLSFDGSTDPKGER----------- 225
            |:.|.|     |||.||   |.|......|.             ||:...:..:
  Rat    83 NSHPAS-----GGGESAGVPLSPSWASGSRG-------------DGNLQRRASQKELRKSFARSK 129

  Fly   226 ----NHAEEEPLTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEE 286
                |...:|.:|.......|.|.||   .|.|||.||                    |||....
  Rat   130 AIHVNRTYDEQVTSRAQEPLSSVRRR---ALLRKASSL--------------------PPTTAHI 171

  Fly   287 FRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAAC--QRH---QLDVTLVKSKEEAL 346
            ......:.::      ||..||              .||...|  ::|   |..:.|||.....|
  Rat   172 LSALLESRVN------LPQYPP--------------TAIDYKCHLKKHNERQFFLELVKDISNDL 216

  Fly   347 DTLQKSY---------ATAQCYHLIIIDARS-------SKNLDAEHIARTIRHTHGHHLTTIIAV 395
            |....||         ..|....|.:::..:       ||..|.             |..|.:..
  Rat   217 DLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDV-------------HAGTPLLP 268

  Fly   396 CKKSFFEKDDVLIALLDAGVNRCV---AETTNL--------------AMCSVELKQILHSIIRPH 443
            |  |..|..:.:......|:...|   .||.|:              .:...:.|.:|...||..
  Rat   269 C--STTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRNS 331

  Fly   444 N--VMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTI 506
            :  ::...|    |::::.|....|:|          .|:::.|.|      ....|.:|:....
  Rat   332 DGEIIGVAQ----AINKVPEGAPFTED----------DEKVMQMYL------PFCGIAISNAQLF 376

  Fly   507 SEQCKNIKEFDGILTV------RRKSQEGIP---MHVRVVPVACIGSAPTHLIFNFDVPGGQMDF 562
            :...|..:....:|.|      .:...|.|.   ||.....:.| ......|:.:.:.|..:...
  Rat   377 AASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC-ERCSVLLLEDIESPVVKFTK 440

  Fly   563 IATLPQPK---EAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKL---TSLPLEAP---------- 611
            ...|..||   :|......||.:.|:      ||.|...|:|:|   |.||:...
  Rat   441 SFELMSPKCSADAENSFKESVEKSSY------SDWLINNSIAELVASTGLPVNVSDAYQDPRFDA 499

  Fly   612 ---------------------------ITKIINLLSQVQENCSADEA--RLIDKVLEF----LKR 643
                                       :.:::|.|    :....|:|  ||.:..:.|    :..
  Rat   500 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL----DGKPFDDADQRLFEAFVIFCGLGINN 560

  Fly   644 EGLYSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPII 708
            ..:|. |:|:......:|.|::.        |.:..|.             |.:...|..:.|::
  Rat   561 TIMYD-QVKKSWAKQSVALDVLS--------YHATCSK-------------AEVDKFKAANIPLV 603

  Fly   709 MELLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNID-ENVCKAWLAVIEAHYRKS 772
            .||..:.:  .||.|.|    |...::...:.||....:.....|| |.:|: ||..:..:||..
  Rat   604 SELAIDDI--HFDDFSL----DVDAMITAALRMFMELGMVQKFKIDYETLCR-WLLTVRKNYRMV 661

  Fly   773 NTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDAL 837
             .|||..||.:|.|...|.:|....:::|.  .:|....::....||:||.|.::||...|:.||
  Rat   662 -LYHNWRHAFNVCQLMFAMLTTAGFQEILT--EVEILAVIVGCLCHDLDHRGTNNAFQAKSDSAL 723

  Fly   838 AVLYNDLTVLENHH--AAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLA 900
            |.||.....||:||  .|:   :.|..:..|||.||..:.|......:...||||::|.:||...
  Rat   724 AQLYGTSATLEHHHFNHAV---MILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRT 785

  Fly   901 KFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEK 965
            :|..:. .:...|.:..:..:   :.|.||:...|:....:|.:...:.|..:..|:|.|.|.|:
  Rat   786 EFFELV-SKGAYDWSITSHRD---VFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRER 846

  Fly   966 QRHLPIVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESF-IDMPQLITYMQINYSQWKKYDEQ 1028
            .........:||| ....:|:.|:.:|:.|...:..|.... ..:..::..:..|..:|::..::
  Rat   847 SELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNAKLKPMLDSVAANRRKWEELHQK 911

  Fly  1029 GVNTLAEIMAKQP 1041
            .:    ::.|..|
  Rat   912 RL----QVSAASP 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	15/88 (17%)
		PAS_9	463..539	CDD:290162	14/84 (17%)
		PDEase_I	775..1016	CDD:278654	64/244 (26%)
Pde11a	NP_543169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..125		13/59 (22%)
		GAF	217..380	CDD:214500	32/197 (16%)
		GAF	402..568	CDD:214500	32/177 (18%)
		PDEase_I	663..898	CDD:278654	64/243 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	915..935		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347775
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850