DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and AgaP_AGAP008967

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_319716.3	Gene:	AgaP_AGAP008967 / 1279930	VectorBaseID:	AGAP008967	Length:	381	Species:	Anopheles gambiae

Alignment Length:	394	Identity:	121/394 - (30%)
Similarity:	189/394 - (47%)	Gaps:	57/394 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 LSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRT------DDPIATDLIGALLTGPSVYSS 677
            ||:||.:....|.           ||.|.|...:::.|      :.|....:..|:..|..|
Mosquito    15 LSEVQPDAVPPEV-----------REWLASTFTRQLATTRKKSDEKPKFRSVAHAIRAGIFV--- 65

  Fly   678 RRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGMEMF 742
                 |.|.|..|||       |.|:..|.::.:|.....|.||:|.|.|..:..|:.|||.::.
Mosquito    66 -----DRIYRRVSST-------ALMQFPPEVVRVLKTLDDWSFDVFALAEAGNCQPVKYLGYDLL 118

  Fly   743 RRFDVFATLNIDENVCKAWLAVIEAHY-RKSNTYHNSTHAADVMQATGAFITQ------LTNKDM 800
            .|:.:.....:.....:.:|..||..| |..|.|||:.|||||.|.....:.|      ||:
Mosquito   119 NRYGMIHKFKVPPATLETFLTRIEEGYCRFRNPYHNNLHAADVAQTVHHVLCQTGLMHWLTD--- 180

  Fly   801 LVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKI 865
                 :|....|:||..||.:|.|.::.|...|....|:||||..||||||.:..|:: |.:|..
Mosquito   181 -----LEIFATLLAALIHDYEHTGTTNNFHVMSGSDTAMLYNDRAVLENHHISAAFRV-LKEDDC 239

  Fly   866 NIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRML 930
            |:.:||.::.::..|:.||||:|||:|:.||:.|....::....|     ||.|:..::   .::
Mosquito   240 NVLQNLSRDEFRELRTLIIDMVLATDMSFHFQQLKNMRNLLTLAE-----PQVDKSKAL---SLV 296

  Fly   931 IKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYII 995
            :...|:|:||:......:|...:.||:|.|.|.|::..||. .|:.||....:.:|||||||:|:
Mosquito   297 LHCCDISHPAKRWDIHHKWTMLLLEEFFRQGDLERELGLPF-SPLCDRNNTLVAESQIGFIEFIV 360

  Fly   996 QDMM 999
            :..|
Mosquito   361 EPSM 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	80/231 (35%)
AgaP_AGAP008967	XP_319716.3	PDEase_I_N	11..67	CDD:285672	14/70 (20%)
AgaP_AGAP008967	XP_319716.3	PDEase_I	152..371	CDD:278654	80/231 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920