DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and AgaP_AGAP008304

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_317162.4	Gene:	AgaP_AGAP008304 / 1277681	VectorBaseID:	AGAP008304	Length:	508	Species:	Anopheles gambiae

Alignment Length:	337	Identity:	81/337 - (24%)
Similarity:	144/337 - (42%)	Gaps:	33/337 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 MKSNP-IIMELLDESLSWDFDIFKL--EEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLA 763
            ||..| .:.|:..:.|...|..|..  .::.|:...:.|.|.||...:...:..|.|.....::.
Mosquito   178 MKVKPSSLSEINQDELYRTFPRFDFCPRDVKDHALSVQLAMRMFYDLNFVGSFKIHEYKLARFVL 242

  Fly   764 VIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSA 828
            :::..|| ...|||..||..|.....:.:..|...:..::.:|:..:.||||..||:||.|.|::
Mosquito   243 LVQKGYR-DTPYHNWWHAFSVAHFAYSLMMNLRLIERGIITKMQGFSFLIAAFCHDLDHRGISNS 306

  Fly   829 FLCNSNDALAVLY-NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEM 892
            :...::..||.|| ::.:|.|.||.:....: |.|....|...|....:|.....:.::||||::
Mosquito   307 YQTQTSSPLARLYSSEGSVNERHHLSQAICI-LNDSSSKILDGLSTTEFKECIDYLRELILATDL 370

  Fly   893 TRHFEHL-------AKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWA 950
            ..||..|       |:::              |:.....|:..::|...|:::..:..:.....|
Mosquito   371 ANHFRILPRLKKLRAEYL--------------TEGSNQRLLLSLMITCCDLNDQIKSWKTVQHVA 421

  Fly   951 RRIAEEYFMQTDEEKQRHLPIVMP--MFDRATCSIPKSQIGFIEYIIQDMMHAW-ESFIDMPQLI 1012
            ..:..|:|.:.|.|||..|   .|  |.||....||..||.|:..:|:...... :.|.:....:
Mosquito   422 HLVYAEFFAEGDLEKQMGL---RPNAMMDRKKACIPMLQIEFLTTVIRPTFEILVQIFPETGSFL 483

  Fly  1013 TYMQINYSQWKK 1024
            ..:..|..||::
Mosquito   484 DTIDSNREQWER 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	62/251 (25%)
AgaP_AGAP008304	XP_317162.4	GAF	1..161	CDD:214500
AgaP_AGAP008304	XP_317162.4	PDEase_I	253..487	CDD:278654	62/251 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920