DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde8 and AgaP_AGAP005536

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_315535.4	Gene:	AgaP_AGAP005536 / 1276218	VectorBaseID:	AGAP005536	Length:	934	Species:	Anopheles gambiae

Alignment Length:	340	Identity:	109/340 - (32%)
Similarity:	176/340 - (51%)	Gaps:	34/340 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 LLDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAW--LAVIEAHYRKSN 773
            :||....|.|:.|.||.:|....|..|.:.:|..:.:....|:|  |.:.|  .::||..|..:|
Mosquito    90 ILDRVNHWRFNAFTLETVTGGRSLPVLCVHLFHWYGLLDHFNLD--VVRVWKLFSLIEEGYHSTN 152

  Fly   774 TYHNSTHAADVMQATGAFITQ---LTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSND 835
            .||||.||.||.||...|:.:   |.|     :..:|...:||.|..||:||||.:..||..:::
Mosquito   153 PYHNSIHATDVTQAMHCFLQEKRILEN-----LSPLEIMASLIGAVTHDLDHPGVNQPFLIATSN 212

  Fly   836 ALAVLYNDLTVLENHH--AAITFKLTLG--DDKINIFKNLDKETYKSARSTIIDMILATEMTRHF 896
            .||.||.:.:||||||  :||...|..|  :...:|...|:::        |..:||||::||..
Mosquito   213 HLAALYENTSVLENHHWRSAIGCLLESGVAEQVQDIRPELERQ--------ISSLILATDITRQQ 269

  Fly   897 EHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQT 961
            |.:.:|.....    ||.....|......:.::.:|.||:|||.||.....:|:.::.||:|.|.
Mosquito   270 EFIGRFRDYLS----RDALDMRDTTHRHFILQISLKCADISNPCRPWDISKKWSTKVCEEFFRQG 330

  Fly   962 DEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMP-QLITYMQINYSQWK 1023
            |.|:|.:|| |..:.||.:.::||.|.||.::::..:|..|..|:  |:. .::.:::.|.:||:
Mosquito   331 DYERQLNLP-VTSLCDRQSTTVPKIQTGFFKFVVTPLMDEWHRFLRTDLSHSMMHHLKYNQTQWE 394

  Fly  1024 KYDEQGVN--TLAEI 1036
            ...:..:|  |..||
Mosquito   395 SKLQAEINEETRTEI 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	83/250 (33%)
AgaP_AGAP005536	XP_315535.4	PDEase_I	154..387	CDD:278654	83/250 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920