Protein Alignment Pde8 and AgaP_AGAP008646

DIOPT Version :9

• Sequence 1: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Sequence 2: XP_314743.3
• Gene: AgaP_AGAP008646 / 1275495
• VectorBaseID: AGAP008646
• Length: 1016
• Species: Anopheles gambiae
• Alignment Length: 995
• Identity: 198/995 - (19%)
• Similarity: 353/995 - (35%)
• Gaps: 298/995 - (29%)

  Fly   182 SFGGGGGRSA----------LQPEIVE-------------------------AIRSLDVPALRLN 211
            :.|||||..|          ..||.::                         |..|:|.|.
Mosquito    14 AIGGGGGYDAEFARMESWLDENPEFMQDYFIRKATRNMVDGWLVSHATPVTTAANSVDSPT---- 74

  Fly   212 NLSFDGSTDPKGERNHAEEEPLTP-----GHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLH 271
                .|:..|...|..:  ...||     .|:.|...:|:..||.::.....|
Mosquito    75 ----HGTNQPSSSRGGS--GATTPVRKISAHEFERGGLLKPIVNTIDGTPTFL------------ 121

  Fly   272 LLVAGKKNPPTEEEEFRTFQ----------RNLMDLKYPTVLPPNPPLKAL----LVFHKSDSIC 322
                 ..:|..|.....:.|          .||..|:    |..| .||.|    |:|.....||
Mosquito   122 -----SISPQNESSASGSTQCCPNGVTYCGANLRPLR----LSRN-ELKQLDERELIFELVKDIC 176

  Fly   323 E--AITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTH 385
            .  .:.:.|.:...:|:::.:.:..              .|.::..:|:...|         :|.
Mosquito   177 NDLDVRSLCHKILQNVSILLNADRG--------------SLFLVQGKSTCGGD---------NTK 218

  Fly   386 GHHLTTIIAVCKKSFFE----KDDVLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVM 446
            ...::.:..||..|..|    :|:|.:| ...|:...|||:.                 .|.|:.
Mosquito   219 KCLVSKLFDVCSNSTLEEMEQQDEVKVA-WGTGIAGHVAESG-----------------EPVNIP 265

  Fly   447 STQQ--------ALYTALHRLKEVVLI-----TDDLLRIQYANRATERLLNMRLDEIISKQLEDI 498
            ...|        .:.|. :|.|.::.:     :.|::.:       .:::|.:.|:..|...|.|
Mosquito   266 DAYQDERFNREIDVQTG-YRTKALLCMPIKDASGDVVGV-------AQVINKQGDQCFSTADEKI 322

  Fly   499 FVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACI----GSAPTHLIFNFDVPGGQ 559
            |.|.|.......:|.:.::       |||..:..:..::.:|.:    .|...|::|..
Mosquito   323 FSSYLQFCGIGLRNAQLYE-------KSQLEVKRNQVLLDLARMIFEEQSTIEHMVFRI------ 374

  Fly   560 MDFIATLPQPK--------EAPRGSLHSVRRCSFDVRSIA-SDGLRRTSLAKLTSLPLEAPITKI 615
            :..:.:|.|.:        ||.:||...|  ..|:...:: .||..|||..: :..|:...||..
Mosquito   375 LTHMQSLIQCQRVQILLVHEASKGSFSRV--FDFEANDLSGEDGDARTSPFE-SRFPINVGITGY 436

  Fly   616 INLLSQVQENCSA-DEARL---IDKVLEFLKREGLYSPQMKEIRTDDPIATDLIG---------- 666
            :....:....|:| ::.|.   :|:.|.|..:..|.......:       :.:||
Mosquito   437 VATTGETVNICNAYEDDRFDPSVDEGLNFRHKTILCMAIKNSL-------SQIIGVIQLINKFDD 494

  Fly   667 --------------ALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLS 717
                          |:..|..::::.....            |.|..||..   :.:|:|....|
Mosquito   495 LTFTKNDENFVEAFAIFCGMGIHNTHMYEK------------AIIAMAKQS---VTLEVLSYHAS 544

  Fly   718 WDFD-------------------IFKLEEIT--DYHPL-----LYLGMEMFRRFDVFATLNIDEN 756
            ...|                   .||.:::|  |.|.|     ::|.:::..||      :|:..
Mosquito   545 ATIDDAYRLRQLKVPSSAFFKLYDFKFDDLTLDDDHTLKACLRMFLDLDLVERF------HIEYE 603

  Fly   757 VCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVD 821
            |...||..::.:|| :.||||..||.:|.|...|.:|  :.:...:...:|....:||...||:|
Mosquito   604 VLCRWLLSVKKNYR-NVTYHNWRHAFNVTQMMFAILT--STQWWKIFGEIECLALIIACLCHDLD 665

  Fly   822 HPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFK---LTLGDDKINIFKNLDKETYKSARSTI 883
            |.|.:::|...::..||.||:..| :|:||    |.   :.:......|..|:..|.|......:
Mosquito   666 HRGTNNSFQIKASSPLAQLYSTST-MEHHH----FDQCLMIINSPGNQILSNMSSEDYSRVIRVL 725

  Fly   884 IDMILATEMTRHFEHLAKF---------VSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNP 939
            .|.||:|::..:|.....|         :|.:..||||.           |:|.|.:.|.|:|..
Mosquito   726 EDAILSTDLAVYFRKRGAFLNLVEPASEMSSWQAEEPRS-----------LLRAMSMTVCDLSAI 779

  Fly   940 ARPMQFCIEWARRIAEEYFMQTDEEKQR-HLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWE 1003
            .:|.:.....|..::.|:|.|.|.|:|. ::..:..|.......:|..|:|||:.|...:..|:.
Mosquito   780 TKPWEIEKRVADLVSSEFFEQGDMERQELNITPIDIMNREKEDQLPMMQVGFIDSICIPIYEAFA 844

  Fly  1004 SFID-MPQLITYMQINYSQW 1022
            :..| :..||..::.|...|
Mosquito   845 TLSDKLTPLIDGVRENKQHW 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	14/84 (17%)
		PAS_9	463..539	CDD:290162	13/80 (16%)
		PDEase_I	775..1016	CDD:278654	67/254 (26%)
AgaP_AGAP008646	XP_314743.3	GAF	180..344	CDD:214500	34/219 (16%)
		GAF	373..524	CDD:214500	27/166 (16%)
		PDEase_I	621..858	CDD:278654	67/254 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920