DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and AgaP_AGAP004119

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_312997.5	Gene:	AgaP_AGAP004119 / 1273943	VectorBaseID:	AGAP004119	Length:	1152	Species:	Anopheles gambiae

Alignment Length:	1097	Identity:	221/1097 - (20%)
Similarity:	375/1097 - (34%)	Gaps:	377/1097 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 STAVPANGGIRPKSEGACPEMKVETISAATSPPPPRPLHGT-----SGPVAISLPFVGRNSSKTP 150
            ||:||::                   :..:|.|..:||:..     :|....::|.:|.....:|
Mosquito    23 STSVPSS-------------------AVDSSDPAEQPLNNNGDRNDNGTGCCTVPKLGSPRPSSP 68

  Fly   151 EEMELEYEANVEAESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALRLNNLSF 215
            .|         ..||.: .|.:|.|:||                       |.|...|...|.|.
Mosquito    69 AE---------NGESAN-CTLMRSNSRP-----------------------STDDGNLLSPNTSR 100

  Fly   216 DGSTDPKGERNHAEEEPLTPGHDH--EDSVVLRRKVN-----------CLERKAHSLYERRLPR- 266
            ...:..:...:|    .|:|.|..  .||:....:::           .:||    .:..|.|.
Mosquito   101 SSMSQSQSPTHH----HLSPSHRSAPADSLCSLEELDEVGAFFEEHSAAIER----WFRERAPND 157

  Fly   267 -VPKLHLLVAG--KKNP---------------------------PT---------------EEEE 286
             |.||..:.||  .|:|                           ||               |.|.
Mosquito   158 VVAKLQSITAGDTSKSPKSPHRASVTSDLFQQWLASSPVKKCRSPTSRSSISNRSHLADLDEGEL 222

  Fly   287 FRTFQR---NLMDL------------------KYPTVLPPNPPLKALLVFHKSDSICEAITAACQ 330
            |....|   |.:|:                  :....|...||....||....|        ..|
Mosquito   223 FMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLVNGPPSGKYLVAKLFD--------VTQ 279

  Fly   331 RHQLDVTLVKSKEEAL---------DTLQKSYAT---AQCYHLIIIDARSSKNLDAE-------- 375
            ...||..:.::|::.:         .|:.::..|   .:.|.    |.|.:..:|.:
Mosquito   280 NTPLDEAVRRAKQDEIIIPFGVGIAGTVAQTNETINIKEAYK----DPRFNSEIDQKTGYKTNII 340

  Fly   376 -------------HIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIA--LLDAGVNRCVAETTNL 425
                         .:|:.|..|:|          ...|.|:|..:..  |...|:....|:...:
Mosquito   341 LSMPICNYEGQVIGVAQIINKTNG----------SPEFTERDVEIFRRYLTFCGIGIQNAQLFEM 395

  Fly   426 AMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITD--DLLRIQYANRATERLLNMRLD 488
            ::......|||.::.|  ::.|.|..|...:.:     ::|:  :||:.:   |....||::...
Mosquito   396 SVQEYRRNQILLNLAR--SIFSEQNNLECLVTK-----IMTEARELLKCE---RCAVFLLDLDCG 450

  Fly   489 EIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNF 553
            |.:||  :|.|...|            .|||              .|::.|....:..|.....|
Mosquito   451 EAVSK--DDEFQHPL------------HDGI--------------ERILTVIHRNTISTRFTMIF 487

  Fly   554 DVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITKIINL 618
            ::                   ||.|.           :|..:.|.|::.|.|           ::
Mosquito   488 EL-------------------GSSHQ-----------SSANILRPSVSDLNS-----------SM 511

  Fly   619 LSQVQENCSA-DEARLIDKVLEFLKREGLYSPQ---MKEIRTDDPIA-------TDLIGALLTGP 672
            |:|:.|..:| .|...|..|||:||.:.:...|   .:....|..:|       |..:.::|..|
Mosquito   512 LAQIAEYVAATGETLNISDVLEWLKDKSICQRQTVVQQAPAADGTVATTDSFDETHSVKSILCMP 576

  Fly   673 SVYSSR---------RSSND--------SI-----------IRTGSSTRTAAIVPAKMKSNPIIM 709
            .:...:         ...||        ||           |.......:|..:.||.|   :.:
Mosquito   577 IINGQKTVIGVAQLINKQNDLQFTNCDISIFEAFAIFCGLGIHNTQMYESACKLMAKQK---VAL 638

  Fly   710 ELL--------DESLSW-------------------DFDIFKLEEITDYHPLLYLGMEMFRRFDV 747
            |.|        |::|..                   |||:       |........:.||.:.::
Mosquito   639 ECLSYHATASQDQTLKLVNDTIQSAEEYKLYSFKFIDFDL-------DDDDTCRAAVRMFLQCNL 696

  Fly   748 FATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATAL 812
            ....:|..:|...|:..:..:||... |||..||.:|.|.  .|....|.|....|..:|....|
Mosquito   697 VQQFHIPYDVLCRWILSVRKNYRPVK-YHNWRHALNVAQT--MFAMMKTGKMERFMTDLEILGLL 758

  Fly   813 IAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFK---LTLGDDKINIFKNLDKE 874
            :|...||:||.|.::||...::..||:||...| :|:||    |.   :.|..:..|||:.|..|
Mosquito   759 VACLCHDLDHRGTNNAFQSKTDSPLAILYTTST-MEHHH----FDQCVMILNSEGNNIFQALSPE 818

  Fly   875 TYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNP 939
            .:::....:...||:|::..:|:...:|:.:.   |..:.:.|::|:..||. .|::...|||..
Mosquito   819 DFRTVMKVVETAILSTDLAMYFKKRNQFLELI---ENGEFDWQSEEKKEILC-GMMMTACDVSAI 879

  Fly   940 ARPMQFCIEWARRIAEEYFMQTDEEKQR--HLPIVMPMFDRATCSIPKSQIGFIEYI 994
            |:|.:.....|:.:|:|:|.|.|.||.:  ..|:.|...:|.. .:||.|:|||:.|
Mosquito   880 AKPWEVQHRVAKLVADEFFDQGDLEKLQLNQQPVAMMDRERKD-ELPKMQVGFIDVI 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	16/81 (20%)
		PAS_9	463..539	CDD:290162	16/77 (21%)
		PDEase_I	775..1016	CDD:278654	70/225 (31%)
AgaP_AGAP004119	XP_312997.5	GAF	235..394	CDD:214500	27/180 (15%)
		GAF	419..626	CDD:214500	50/283 (18%)
		PDEase_I	723..956	CDD:278654	70/225 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920