DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and AgaP_AGAP000236

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_003436945.1	Gene:	AgaP_AGAP000236 / 1272025	VectorBaseID:	AGAP000236	Length:	1365	Species:	Anopheles gambiae

Alignment Length:	1273	Identity:	283/1273 - (22%)
Similarity:	432/1273 - (33%)	Gaps:	409/1273 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKSSAKSSSSSAGRENPSSEPDSDTEPYAIAIAAISDR---SGDNRNERPRPLPDDDSIRSRL-- 73
            |.:||:||.|.|     |.|...|||..|:.......|   .|..|.||.|......|:...:
Mosquito   192 RGASARSSGSGA-----SGETLKDTEKGALRSGTGRGRDRGDGVGRGERGRRGGGGGSVEESIGC 251

  Fly    74 -----------ISAAHL-DLDVGL-------ELASDSTAVPANGGIRPKSEGACPEMKVETISAA 119
                       .|||.: |...|:       :..:.:|.|..:|.....|..........||...
Mosquito   252 GSGTGRADGTPESAAGVGDSGGGVGGTNTPGDAVAMATVVSGDGKQTTGSLTTTTTTTTTTILTG 316

  Fly   120 TSPPPPRPLHGTSGPVAISLPFVGRNSSKTPEEMELEYEANVEAESRDIMTPLRRNTRP------ 178
            ..    ||.:.|.|.:..||   .:......||.:.:.|...:.:..|...|.|....|
Mosquito   317 NG----RPRNSTRGVLQASL---AKQEEDDDEEADTDTEMQGQQDDSDAGVPPREMVGPEPGTVQ 374

  Fly   179 ------LSVSFGGGG-------------------GRSALQ-PEIVEAIR-------SLDVPALRL 210
                  :.:..||.|                   |.||.| |:::..||       |.|....|
Mosquito   375 PQHPYAIGLLAGGAGLMGGSGRPGAHQRPAGRHRGTSAQQHPQLLPHIREERKRNGSADATVRR- 438

  Fly   211 NNLSFDGSTDPKG----------------------------------ERNHAEEEPLTPGH--DH 239
               ..|...|..|                                  ||:..|:|.:..|:  |.
Mosquito   439 ---EADDEADTSGSMMEEEEEEEDEEEEEARAGESLEVGRKEAADEEERDDDEQEEIDDGYSADE 500

  Fly   240 EDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLV-------AGKKN---PPTEEEEFRTFQRNL 294
            :||.                  ||:..||.:..:.       |||..   ||...:..|..:..|
Mosquito   501 DDSA------------------RRVLAVPLIPTVAGAGKYQQAGKPQQQLPPPHPKYHRNRRHTL 547

  Fly   295 MDLKY---------------------------PTVLP--------PNPPLKALL------VFHKS 318
            .::::                           |.:||        |...|.|.|      ..::|
Mosquito   548 ANVRFMDNAEGSGSGPPSGVMSVVGGYTSRRSPLLLPSGDGGPGGPGALLSAALPQRRESFLYRS 612

  Fly   319 DSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRH 383
            ||..|               :..|..::..|     .|:|.........|:.|:.:.....|:..
Mosquito   613 DSDFE---------------ISPKVSSVSLL-----AARCSANNSGSGTSTSNVASTGSGTTLTS 657

  Fly   384 THGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVA----ETTNLAMCSVELKQILHSIIRPHN 444
            ..|.                       :..|.:|..|    ||:.|     |...:|.||
Mosquito   658 GGGG-----------------------VTGGGSRDGAFHWKETSTL-----EEPAVLSSI----- 689

  Fly   445 VMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNM----------RLDEIISKQLEDIF 499
            ..|...:..|.:......|:          .:..:||...|          ..|::|......|.
Mosquito   690 ASSPSSSATTVVGAASSTVV----------TSSTSERTTMMSGSGGGGSSGHHDDLIVTPFAQIL 744

  Fly   500 VSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHLIFNFDVPGGQMDFIA 564
            .|                 :.|||..             :..:.||
Mosquito   745 AS-----------------LRTVRSN-------------LYALSSA------------------- 760

  Fly   565 TLPQPKE-APRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEA--PITKIINLLSQVQENC 626
             ||:..| |.|.|.........|..|.|.|..:......|..|..|.  .:...:..|..||.:.
Mosquito   761 -LPEESELATRRSSAGAESAETDPGSAAGDDSQPDKDGDLRQLTTETIDELEWCLEQLETVQTHR 824

  Fly   627 SADE------ARLIDKVLEFLKREGLYSPQMKEI---------RTDDPIATDLIGALLTGPSVYS 676
            |..:      .||::|.|..|........|:.|.         :..|..:..|:|:.|.|....:
Mosquito   825 SVSDMASLKFKRLLNKELSHLSESSKSGNQISEYICTTFLDKQQEPDVPSAPLVGSALIGRPTGA 889

  Fly   677 SRRSSN--------------------------DSIIRTGSSTRTAAIVPAKMKSNPIIMELLDES 715
            :.|.|.                          |.:...|..|.|||       ....:..||.:.
Mosquito   890 AGRMSEISGFKRPLQHTNSFSGAAGAGVTSLADRLPPYGVPTATAA-------DEAELGGLLGQI 947

  Fly   716 LSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTH 780
            ..|..|||::..::...||..:...:|:..::..||.|...|..|:::.:|.||...|.:|||.|
Mosquito   948 DQWGVDIFRIGTLSGSRPLTAVAYTVFQDRNIPRTLTIPPTVLLAFVSTVEDHYVADNPFHNSLH 1012

  Fly   781 AADVMQATGAFITQLTNKDML--VMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYND 843
            ||||.|:|.|    |.:...|  |...:|...||:||..|||||||.::.||.||:..||::|||
Mosquito  1013 AADVTQSTHA----LLHSPALDGVFTPLEVCAALVAACIHDVDHPGLTNQFLINSSSELALMYND 1073

  Fly   844 LTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLA-------- 900
            .:||||||.|:.|||...|| .||.:||.|:...:.|..:|||:|:|:|::|...||
Mosquito  1074 ESVLENHHLAVAFKLMQNDD-CNILRNLPKKQRATFRKMVIDMVLSTDMSKHMTLLADLKTMVET 1137

  Fly   901 KFVSVFGGEEPRDHNPQTDEETSILMRRM------------LIKVADVSNPARPMQFCIEWARRI 953
            |.|::.|.:.|.:   .....:.:|:|.:            |:..||:|||.:|:.....|.||:
Mosquito  1138 KKVAISGNQNPGE---SRSSGSGVLLRLLDSYTDRIQVLQNLVHCADLSNPTKPLPLYRRWVRRL 1199

  Fly   954 AEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQ 1016
            .||:|.|.|.|:...:. |.||.||.:.::..||:|||:||:..:..||...:  |...::..::
Mosquito  1200 MEEFFRQGDRERAAGMD-VSPMCDRRSATVESSQVGFIDYIVHPLWEAWAELVRPDAQDILDRLE 1263

  Fly  1017 INYSQWK--------------KYDEQGVNTLAEIMAKQ 1040
            .|.:.::              :.:|:.....|:..|||
Mosquito  1264 ENRAYYQALIPPPSPPSHEKDEEEEEEAEEAAKREAKQ 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	11/89 (12%)
		PAS_9	463..539	CDD:290162	11/85 (13%)
		PDEase_I	775..1016	CDD:278654	99/264 (38%)
AgaP_AGAP000236	XP_003436945.1	PDEase_I	1007..1263	CDD:278654	99/264 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920