DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and AgaP_AGAP007163

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_308604.4	Gene:	AgaP_AGAP007163 / 1269950	VectorBaseID:	AGAP007163	Length:	958	Species:	Anopheles gambiae

Alignment Length:	1040	Identity:	517/1040 - (49%)
Similarity:	666/1040 - (64%)	Gaps:	134/1040 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SSSAGRENPSSEPDSDTEPYAIAIAAISD---RSGDNRNERPRPLPDDDSIRSRLISAAHLDLDV 83
            :::.||.:.......|.|.|...:...:.   .:|.|..::.:...|.......:.|:.:...|.
Mosquito    15 TAAVGRNHSHDHNKDDGEDYHQTVMGCTPSILSNGSNNQQQQQSRKDSGLYVGNVTSSGNGSNDT 79

  Fly    84 GLELASDSTAVPANGGIRPKSEGACPEMKVETISAATSPPPPRPLHGTSGPVAISLPFVGRNSSK 148
                   |.|..|..|...|...:.|                      ..|..::.|:.|
Mosquito    80 -------SNAAAAAAGNNNKLSNSSP----------------------VNPTMVNAPYPG----- 110

  Fly   149 TPEEMELEYEANVEAESRDIMTPLRRNTRPLSVSFGGGGGRSALQPEIVEA-----IRSLDVPAL 208
                          |.|:|                ||....||.:..||..     |.|..|.:.
Mosquito   111 --------------AASKD----------------GGTEKESAKKDSIVSISATGHITSFPVVST 145

  Fly   209 RLNN-LSFDGSTDPKGERNHAEEE-PLTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLH 271
            .:.. .:..|::...|...|.:.. .|||
Mosquito   146 TVRRPTAGSGTSSSSGRYGHRKSSLALTP------------------------------------ 174

  Fly   272 LLVAGKKNPPTEEEEFRTFQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDV 336
                       |||...:..|.:.|||:|.:|||||.:|.|:.|.|:|.:.||:..|..|..|:.
Mosquito   175 -----------EEEPLDSCPRLVSDLKFPNLLPPNPVIKILIAFCKNDPVFEALVNASHRLSLEP 228

  Fly   337 TLVKSKEEALDTLQKSYATAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFF 401
            |.|||.|.|:|..|.  .::..:|:||:|||..:.::||.:.|:||::.|...||::||.|||.|
Mosquito   229 TFVKSAESAIDAFQN--PSSGGHHIIIVDARYPRTIEAEALGRSIRNSKGSQHTTMVAVVKKSVF 291

  Fly   402 EKDD-VLIALLDAGVNRCVAETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLI 465
            |||| .:|:|||.|.|||:.|:.::::||.||:||.||::||.||:||||||||||||.:|.|:|
Mosquito   292 EKDDTAVISLLDVGYNRCIIESPHVSICSSELRQIQHSLVRPQNVISTQQALYTALHRSREAVII 356

  Fly   466 TDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGI 530
            |||.||.||||||:||:|||:||||:.:.|.|:..:|:|.|.......|::||.||.||||||..
Mosquito   357 TDDTLRAQYANRASERVLNMKLDEIVGRSLSDLVTADISNILSHTSRYKDYDGYLTTRRKSQESS 421

  Fly   531 PMHVRVVPVACIGSAPTHLIFNFDVPGGQM-------DFIATLPQPKEAPRGSLHSVRRCSFDVR 588
            .:|||.|||:|||..||||:...:.....:       :.:.||||.||.|||||||:||.|||||
Mosquito   422 QIHVRAVPVSCIGRNPTHLVLILESSSSALVSTNAIGEALQTLPQGKEVPRGSLHSIRRGSFDVR 486

  Fly   589 SIASDGLRRTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKE 653
            |||||||||||||||:||||||||||:::||:|||||||.|||:|:|:|:|||||||||||||||
Mosquito   487 SIASDGLRRTSLAKLSSLPLEAPITKVLSLLAQVQENCSLDEAKLLDRVMEFLKREGLYSPQMKE 551

  Fly   654 IRTDDPIATDLIGALLT-GP-SVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESL 716
            |||:||:|||||||||| || ::.||||||||||||.|....|.:||..|.|.:..:.:||..:|
Mosquito   552 IRTEDPVATDLIGALLTQGPTNILSSRRSSNDSIIRGGGRPSTGSIVFNKTKESSQLSDLLQTAL 616

  Fly   717 SWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHA 781
            .|||:|||||::|:..||:.||:|:||||||:.|.|.||...|.||..:|.||...|||||||||
Mosquito   617 DWDFEIFKLEDLTEKRPLVCLGLELFRRFDVYNTFNCDEMTFKLWLIEMEKHYHSENTYHNSTHA 681

  Fly   782 ADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTV 846
            |||||||..::.||:|:::.:||||:|||||||||.||:|||||||||||||::.||:||||:.|
Mosquito   682 ADVMQATAVYLQQLSNRELKIMDRMDEATALIAAATHDIDHPGRSSAFLCNSDNTLALLYNDICV 746

  Fly   847 LENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGE-E 910
            ||:||||.||:||||||||||||:||::.||.|||.|:|||||||||||||||||||||||.: |
Mosquito   747 LESHHAATTFRLTLGDDKINIFKHLDRDMYKLARSIIVDMILATEMTRHFEHLAKFVSVFGTDVE 811

  Fly   911 PRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPM 975
            .:|..|..:::..||:||||||.||||||.||::||:||||||||||||||||||:::|||||||
Mosquito   812 SKDPLPPDNDDNQILVRRMLIKCADVSNPTRPLKFCVEWARRIAEEYFMQTDEEKRKNLPIVMPM 876

  Fly   976 FDRATCSIPKSQIGFIEYIIQDMMHAWESFIDMPQLITYMQINYSQWKKYDEQGVNTLAEIMAKQ 1040
            |||.||||.|||||||||||.|||.||.|||:||::|.||:.||||||.::|||:|||::|..||
Mosquito   877 FDRTTCSISKSQIGFIEYIIHDMMDAWNSFIEMPEIIRYMEFNYSQWKLFEEQGINTLSDIKRKQ 941

Fly 1041 1040
Mosquito 942 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	43/79 (54%)
		PAS_9	463..539	CDD:290162	42/75 (56%)
		PDEase_I	775..1016	CDD:278654	179/241 (74%)
AgaP_AGAP007163	XP_308604.4	PAS	350..445	CDD:238075	52/94 (55%)
		PAS_9	352..445	CDD:290162	52/92 (57%)
		PDEase_I	675..917	CDD:278654	179/241 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	374	1.000	Domainoid score	I2466
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2758
Inparanoid	1	1.050	1008	1.000	Inparanoid score	I895
OMA	1	1.010	-	-		QHG50014
OrthoDB	1	1.010	-	-		D80286at33208
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	1	1.000	-	-		oto105794
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2464
TreeFam	0	0.000	Not matched by this tool.
	11	11.080