DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde8 and Pde4c

DIOPT Version :9

Sequence 1:	NP_001163275.2	Gene:	Pde8 / 37741	FlyBaseID:	FBgn0266377	Length:	1050	Species:	Drosophila melanogaster
Sequence 2:	XP_011240550.1	Gene:	Pde4c / 110385	MGIID:	99556	Length:	745	Species:	Mus musculus

Alignment Length:	446	Identity:	141/446 - (31%)
Similarity:	224/446 - (50%)	Gaps:	59/446 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   597 RTSLAKLTSLPLEAPITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIA 661
            |.|:.::.|...:..:.:.::.||:.        :|..::|.|::.:  .:..|..|:....|..
Mouse   287 RRSVGEMASNKFKRMLNRELSYLSET--------SRSGNQVSEYISQ--TFLDQQAEVELPQPPT 341

  Fly   662 TDLIGALLTGP----SVYSSRRSSNDSIIRTGSSTRTAAI--VPAKMKSNPIIMELLDESLSWDF 720
            .|       .|    .:...||||:.|:       .||||  ...:......:.:.|:::..|..
Mouse   342 ED-------DPWPMAQITELRRSSHTSL-------PTAAIPRFGVQTDQEEQLAKELEDTNKWGL 392

  Fly   721 DIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYHNSTHAADVM 785
            |:||:.|::...||..:...:|:..|:..|..|..:...|:|..:|.||.....||||.|||||:
Mouse   393 DVFKVAELSGNRPLTAVIFSVFQERDLLKTFQIPADTLLAYLLTLEGHYHSDVAYHNSMHAADVV 457

  Fly   786 QATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENH 850
            |:  |.:...|.....|...:|...|:.|.|.|||||||.|:.||.|:|..||::|||.:|||||
Mouse   458 QS--AHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENH 520

  Fly   851 HAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHN 915
            |.|:.|||..|:: .:||:||..:...|.|..:|||:|||:|::|...||...::.
Mouse   521 HLAVGFKLLQGEN-CDIFRNLSTKQRLSLRRMVIDMVLATDMSKHMSLLADLKTMV--------- 575

  Fly   916 PQTDEETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRH 968
             :|.:.||            |.:.:.|:..||:||||:|:....:|..||..|:|.|.|.|::..
Mouse   576 -ETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESG 639

  Fly   969 LPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQINYSQW 1022
            |.| .||.|:.|.|:.|||:|||:||.|.:...|...:  |..:|:..::.| .:|
Mouse   640 LDI-SPMCDKHTASMEKSQVGFIDYIAQPLWETWADLVHPDAQELLDTLEDN-REW 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde8	NP_001163275.2	PAS	459..539	CDD:238075
		PAS_9	463..539	CDD:290162
		PDEase_I	775..1016	CDD:278654	100/254 (39%)
Pde4c	XP_011240550.1	PDE4_UCR	213..329	CDD:375549	8/51 (16%)
Pde4c	XP_011240550.1	PDEase_I	447..688	CDD:365964	100/254 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0000302
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850